zoanthenol has been researched along with Osteoporosis* in 1 studies
1 other study(ies) available for zoanthenol and Osteoporosis
Article | Year |
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Synthesis and preliminary biological evaluation of truncated zoanthenol analogues.
Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators. While the structure of zoanthamines, especially the ABC-ring portion, is similar to that of steroids, the CDEFG-ring portion, composed of aminoacetal and lactone core, is a unique structural element. In this report, we designed and synthesized ABC-ring 6 and CDEFG-ring 7, which are truncated analogues of the northern and southern hemispheres of zoanthenol 5, respectively, and which incorporate all of the functionality of each hemisphere. A preliminary SAR study suggested that the hydrochloride of the CEFG-ring portion is an active pharmacophore for suppressing the growth of interleukin-6-dependent MH60 cells. Topics: Alkaloids; Animals; Cell Proliferation; Cnidaria; Dose-Response Relationship, Drug; Drug Design; Heterocyclic Compounds, Bridged-Ring; Hybridomas; Interleukin-6; Mice; Molecular Mimicry; Osteoporosis; Structure-Activity Relationship | 2004 |