zn(ii)-phthalocyanine and Uterine-Cervical-Neoplasms

zn(ii)-phthalocyanine has been researched along with Uterine-Cervical-Neoplasms* in 3 studies

Trials

1 trial(s) available for zn(ii)-phthalocyanine and Uterine-Cervical-Neoplasms

Article	Year
Antibody-targeted photodynamic therapy. Hybridoma, 1993, Volume: 12, Issue:5 Topics: Antibodies, Neoplasm; Antigens, Tumor-Associated, Carbohydrate; Breast Neoplasms; Female; Humans; Indoles; Isoindoles; Laser Therapy; Neoplasms; Organometallic Compounds; Ovarian Neoplasms; Photochemotherapy; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms; Zinc Compounds	1993

Other Studies

2 other study(ies) available for zn(ii)-phthalocyanine and Uterine-Cervical-Neoplasms

Article	Year
Phototoxicity of Liposomal Zn- and Al-phthalocyanine Against Cervical and Oral Squamous Cell Carcinoma Cells In Vitro. Medical science monitor basic research, 2016, Dec-09, Volume: 22 Background Material and Methods Results Conclusions. Topics: 1,2-Dipalmitoylphosphatidylcholine; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Head and Neck Neoplasms; HeLa Cells; Humans; Indoles; Isoindoles; Liposomes; Mouth Neoplasms; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms; Zinc Compounds	2016
A Protein-Polymer Bioconjugate-Coated Upconversion Nanosystem for Simultaneous Tumor Cell Imaging, Photodynamic Therapy, and Chemotherapy. ACS applied materials & interfaces, 2016, Dec-07, Volume: 8, Issue:48 Combined cancer therapy possesses many advantages including improved tumoricidal efficacy, reduced side effects, and retarded drug resistance. Herein, a protein-polymer bioconjugate-coated multifunctional upconversion nanosystem, consisting of upconversion nanoparticles (UCNs) core, tailored amphiphilic protein-polymer bioconjugate shell, and photosensitizer zinc phthalocyanine (ZnPc) and antitumor drug doxorubicin coloaded inside, was elaborately developed for combined photodynamic therapy (PDT) and chemotherapy. In this system, UCNs core could convert deep penetrating near-infrared light to visible light for simultaneous cell fluorescence imaging and photodynamic therapy by activating ZnPc to generate cytotoxic ROS, while the protective shell of bovine serum albumin-poly(ε-caprolactone) (BSA-PCL) offered excellent water solubility, good stability, and low cytotoxicity. The ROS production test showed that this nanosystem could successfully generate singlet oxygen under NIR irradiation. A cellular uptake study demonstrated that intense fluorescence emission of the UCNs could be observed in HeLa cells, indicating their outstanding real-time imaging capability. More importantly, compared with single PDT or chemotherapy systems, the constructed combined therapy UCNs system demonstrated significantly enhanced tumor cell killing efficiency. On the basis of our findings, this multifunctional UCNs nanosystem could be a promising versatile theranostic nanoplatform for image-guided combined cancer therapy. Topics: Antibiotics, Antineoplastic; Doxorubicin; Drug Carriers; Drug Delivery Systems; Female; HeLa Cells; Humans; Indoles; Isoindoles; Nanoparticles; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Polyesters; Reactive Oxygen Species; Serum Albumin, Bovine; Uterine Cervical Neoplasms; Zinc Compounds	2016

Article

Year

Phototoxicity of Liposomal Zn- and Al-phthalocyanine Against Cervical and Oral Squamous Cell Carcinoma Cells In Vitro.

Medical science monitor basic research, 2016, Dec-09, Volume: 22

Background Material and Methods Results Conclusions.

Topics: 1,2-Dipalmitoylphosphatidylcholine; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Head and Neck Neoplasms; HeLa Cells; Humans; Indoles; Isoindoles; Liposomes; Mouth Neoplasms; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Squamous Cell Carcinoma of Head and Neck; Uterine Cervical Neoplasms; Zinc Compounds

2016

A Protein-Polymer Bioconjugate-Coated Upconversion Nanosystem for Simultaneous Tumor Cell Imaging, Photodynamic Therapy, and Chemotherapy.

ACS applied materials & interfaces, 2016, Dec-07, Volume: 8, Issue:48

Combined cancer therapy possesses many advantages including improved tumoricidal efficacy, reduced side effects, and retarded drug resistance. Herein, a protein-polymer bioconjugate-coated multifunctional upconversion nanosystem, consisting of upconversion nanoparticles (UCNs) core, tailored amphiphilic protein-polymer bioconjugate shell, and photosensitizer zinc phthalocyanine (ZnPc) and antitumor drug doxorubicin coloaded inside, was elaborately developed for combined photodynamic therapy (PDT) and chemotherapy. In this system, UCNs core could convert deep penetrating near-infrared light to visible light for simultaneous cell fluorescence imaging and photodynamic therapy by activating ZnPc to generate cytotoxic ROS, while the protective shell of bovine serum albumin-poly(ε-caprolactone) (BSA-PCL) offered excellent water solubility, good stability, and low cytotoxicity. The ROS production test showed that this nanosystem could successfully generate singlet oxygen under NIR irradiation. A cellular uptake study demonstrated that intense fluorescence emission of the UCNs could be observed in HeLa cells, indicating their outstanding real-time imaging capability. More importantly, compared with single PDT or chemotherapy systems, the constructed combined therapy UCNs system demonstrated significantly enhanced tumor cell killing efficiency. On the basis of our findings, this multifunctional UCNs nanosystem could be a promising versatile theranostic nanoplatform for image-guided combined cancer therapy.

Topics: Antibiotics, Antineoplastic; Doxorubicin; Drug Carriers; Drug Delivery Systems; Female; HeLa Cells; Humans; Indoles; Isoindoles; Nanoparticles; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Polyesters; Reactive Oxygen Species; Serum Albumin, Bovine; Uterine Cervical Neoplasms; Zinc Compounds

2016