zn(ii)-phthalocyanine and Pancreatic-Neoplasms

zn(ii)-phthalocyanine has been researched along with Pancreatic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for zn(ii)-phthalocyanine and Pancreatic-Neoplasms

Article	Year
Selective Photokilling of Human Pancreatic Cancer Cells Using Cetuximab-Targeted Mesoporous Silica Nanoparticles for Delivery of Zinc Phthalocyanine. Molecules (Basel, Switzerland), 2018, Oct-24, Volume: 23, Issue:11 Photodynamic therapy (PDT) is a non-invasive and innovative cancer therapy based on the photodynamic effect. In this study, we sought to determine the singlet oxygen production, intracellular uptake, and in vitro photodynamic therapy potential of Cetixumab-targeted, zinc(II) 2,3,9,10,16,17,23,24-octa(tert-butylphenoxy))phthalocyaninato(2-)-N. Imidazole-capped Cetuximab-targeted mesoporous silica nanoparticles are excellent vehicles for the selective delivery of ZnPcOBP to pancreatic cancer cells expressing the EGFR receptor. The novel nanosystem appears to be a suitable agent for photodynamic therapy of pancreatic tumors. Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Humans; Indoles; Isoindoles; Light; Nanoparticles; Organometallic Compounds; Pancreatic Neoplasms; Photochemotherapy; Photosensitizing Agents; Porosity; Silicon Dioxide; Singlet Oxygen; Zinc Compounds	2018
Dual Nuclear/Fluorescence Imaging Potantial of Zinc(II) Phthalocyanine in MIA PaCa-2 Cell Line. Current radiopharmaceuticals, 2016, Volume: 9, Issue:3 Pancreatic cancer is very common and difficult to diagnose in early stage. Imaging systems for diagnosing cancer have many disadvantages. However, combining different imaging modalities offers synergistic advantages. Optical imaging is the most multidirectional and widely used imaging modality in both clinical practice and research.. In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine- 131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines.. The intracellular uptake efficiency of radiolabeled Zn(II)Pc in MIA PaCa-2 cells was determined two times higher than WI-38 cells. Also, fluorescence imaging (FI) efficiency of synthesized Zn(II)Pc was investigated in MIA PaCa-2 cells and significant uptake was observed.. Zn(II)Pc might be used as a new agent for dual fluorescence/nuclear imaging for pancreatic cancer. Topics: Cell Line, Tumor; Diagnostic Imaging; Fluorescence; Humans; In Vitro Techniques; Indoles; Iodine Radioisotopes; Isoindoles; Organometallic Compounds; Pancreatic Neoplasms; Radiochemistry; Radiopharmaceuticals; Zinc Compounds	2016

Article

Year

Selective Photokilling of Human Pancreatic Cancer Cells Using Cetuximab-Targeted Mesoporous Silica Nanoparticles for Delivery of Zinc Phthalocyanine.

Molecules (Basel, Switzerland), 2018, Oct-24, Volume: 23, Issue:11

Photodynamic therapy (PDT) is a non-invasive and innovative cancer therapy based on the photodynamic effect. In this study, we sought to determine the singlet oxygen production, intracellular uptake, and in vitro photodynamic therapy potential of Cetixumab-targeted, zinc(II) 2,3,9,10,16,17,23,24-octa(tert-butylphenoxy))phthalocyaninato(2-)-N. Imidazole-capped Cetuximab-targeted mesoporous silica nanoparticles are excellent vehicles for the selective delivery of ZnPcOBP to pancreatic cancer cells expressing the EGFR receptor. The novel nanosystem appears to be a suitable agent for photodynamic therapy of pancreatic tumors.

Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Humans; Indoles; Isoindoles; Light; Nanoparticles; Organometallic Compounds; Pancreatic Neoplasms; Photochemotherapy; Photosensitizing Agents; Porosity; Silicon Dioxide; Singlet Oxygen; Zinc Compounds

2018

Dual Nuclear/Fluorescence Imaging Potantial of Zinc(II) Phthalocyanine in MIA PaCa-2 Cell Line.

Current radiopharmaceuticals, 2016, Volume: 9, Issue:3

Pancreatic cancer is very common and difficult to diagnose in early stage. Imaging systems for diagnosing cancer have many disadvantages. However, combining different imaging modalities offers synergistic advantages. Optical imaging is the most multidirectional and widely used imaging modality in both clinical practice and research.. In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine- 131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines.. The intracellular uptake efficiency of radiolabeled Zn(II)Pc in MIA PaCa-2 cells was determined two times higher than WI-38 cells. Also, fluorescence imaging (FI) efficiency of synthesized Zn(II)Pc was investigated in MIA PaCa-2 cells and significant uptake was observed.. Zn(II)Pc might be used as a new agent for dual fluorescence/nuclear imaging for pancreatic cancer.

Topics: Cell Line, Tumor; Diagnostic Imaging; Fluorescence; Humans; In Vitro Techniques; Indoles; Iodine Radioisotopes; Isoindoles; Organometallic Compounds; Pancreatic Neoplasms; Radiochemistry; Radiopharmaceuticals; Zinc Compounds

2016