zithromax and Uveitis--Anterior

To report a case of severe bilateral anterior uveitis associated with Mycoplasma pneumoniae without pulmonary manifestations.. A healthy 5-year-old girl developed severe bilateral anterior uveitis accompanied by fever, arthralgia, gastrointestinal complaints, and lethargy. Results of laboratory investigations were normal except for high levels of Mycoplasma pneumoniae antibodies. The uveitis subsided with topical application of steroids, cycloplegia, and with oral azithromycin. Although Mycoplasma pneumoniae is a rare cause of uveitis, it should be considered in patients presenting with uveitis, even with no accompanying pulmonary or other typical systemic mycoplasmal manifestations.

Topics: Acute Disease; Anti-Bacterial Agents; Antibodies, Bacterial; Azithromycin; Child, Preschool; Dexamethasone; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Functional Laterality; Glucocorticoids; Humans; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; Uveitis, Anterior

To investigate the efficacy of azithromycin in patients with ocular toxoplasmosis.. 11 immunocompetent patients with ocular toxoplasmosis were treated with azithromycin (500 mg the first day, followed by 250 mg/day for 5 weeks). Ocular and systemic examinations were performed during active retinitis episodes and all patients were followed for at least 1 year.. The intraocular inflammation disappeared within 4 weeks in seven patients, including two cases with progressive retinitis despite previous treatment with pyrimethamine, sulphadiazine, and folinic acid. Recurrence of retinitis occurred in three patients (27%) within the first year of follow up. No systemic side effects of azithromycin were encountered.. These results indicate that although azithromycin cannot prevent recurrent disease it may be an effective alternative for patients with ocular toxoplasmosis who cannot tolerate standard therapies.

Topics: Adult; Aged; Anti-Bacterial Agents; Azithromycin; Female; Follow-Up Studies; Humans; Male; Middle Aged; Recurrence; Retinitis; Toxoplasmosis, Ocular; Treatment Failure; Uveitis, Anterior