zithromax and Thrombocytopenia

Topics: Aged; Anemia; Anti-Infective Agents; Atovaquone; Azithromycin; Babesia microti; Babesiosis; Canada; Humans; Male; Thrombocytopenia; Treatment Outcome

Topics: Adrenal Cortex Hormones; Anticoagulants; Azithromycin; Combined Modality Therapy; COVID-19; COVID-19 Drug Treatment; Delayed Diagnosis; Diagnostic Errors; Erythrocyte Transfusion; Female; Humans; Hydroxychloroquine; Immunocompromised Host; Osteonecrosis; Oxygen Inhalation Therapy; Rheumatic Fever; SARS-CoV-2; Sickle Cell Trait; Splenectomy; Superinfection; Tachycardia; Thrombocytopenia; Young Adult

A 60-year-old female patient living in Southeast China presented with persistent fever, chills, night sweats, fatigue, and dizziness of 12-day duration. Blood tests showed neutropenia, thrombocytopenia, and active hemolytic anemia, with elevated C-reactive protein. Broad-spectrum antibiotics were administered for a possible diagnosis of sepsis, without any response. Malaria was initially diagnosed after visualizing intraerythrocytic ring-shaped parasites in bone marrow and blood smears. The patient resided in an area of unstable endemicity for Plasmodium falciparum. Blood samples were sent to the Centers for Disease Control and Prevention and a definitive diagnosis of human babesiosis was made using Babesia microti-specific PCR. Chloroquine phosphate and clindamycin were started and the patient became normothermic. However, due to the intolerable adverse effects of the antibiotics, intravenous azithromycin was given as an alternative. The patient recovered from fever and hemolysis, and repeated peripheral blood smears showed hemoparasite clearance. Cases of human babesiosis are rarely reported and probably under-diagnosed in China; therefore, improving our understanding of this disease as a newly emerging public health threat is imperative.

Topics: Administration, Intravenous; Anemia, Hemolytic; Anti-Bacterial Agents; Azithromycin; Babesiosis; C-Reactive Protein; China; Chloroquine; Clindamycin; Female; Fever; Humans; Middle Aged; Neutropenia; Thrombocytopenia

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease with a high mortality rate. Infection can also occur through close contact with an infected patient. Scrub typhus is an acute febrile illness caused by

Topics: Aged; Anti-Bacterial Agents; Azithromycin; Bites and Stings; Bunyaviridae Infections; Ceftriaxone; Coinfection; Female; Genotype; Humans; Leukopenia; Molecular Diagnostic Techniques; Orientia tsutsugamushi; Phlebovirus; Phylogeny; Republic of Korea; Scrub Typhus; Thrombocytopenia; Tick-Borne Diseases; Treatment Outcome

Topics: Aged; Anemia; Anti-Infective Agents; Atovaquone; Azithromycin; Babesiosis; Electrocardiography; Fatigue; Fever; Humans; Jaundice; Male; Reticulocyte Count; Thrombocytopenia

Topics: Acute Kidney Injury; Adult; Azithromycin; Diagnosis, Differential; Fever of Unknown Origin; Hantavirus Infections; Humans; Male; Thrombocytopenia