zithromax and Skin-Neoplasms

Full thickness grafts on the nose do not always heal without problems. Partial or entire necrosis of the graft is likely to lead to less favourable cosmetic results and prolonged wound care. No consensus exists as to the use of systemic antibiotics to increase the success rate of survival of a full thickness skin graft on the nose after non-melanoma skin cancer surgery.. The objective of the study was to evaluate the effect of systemic antibiotics on the survival of full thickness grafts on the nose.. We performed a randomized, controlled trial in which we compared azithromycin with standard treatment in 30 patients, who underwent a full thickness graft reconstruction of a surgical defect on the nose after surgery for non-melanoma skin cancer. Percentage survival of the graft was the main outcome measure.. A statistically significant difference in favour of the grafts treated with azithromycin was seen (P=0.002). Of all the variables analysed, only smoking had a significant negative effect on the survival of the graft.. Systemic antibiotics with an accurate bacterial spectrum should be advised in full thickness skin graft reconstruction after surgery for non-melanoma skin cancer of the nose. Smoking should be strongly discouraged.

Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Azithromycin; Carcinoma, Basal Cell; Female; Graft Survival; Humans; Male; Middle Aged; Nose; Nose Neoplasms; Plastic Surgery Procedures; Skin Neoplasms; Skin Transplantation; Treatment Outcome

Topics: Azithromycin; Biopsy, Needle; Dermatitis; Follow-Up Studies; Humans; Immunohistochemistry; Male; Papilloma; Precancerous Conditions; Prurigo; Risk Assessment; Skin Neoplasms; Young Adult

Confluent and reticulated papillomatosis is a relatively rare dermatosis of unknown origin. It is characterized by papules that become confluent in the center and reticulated at the periphery. The sites of predilection are the neck, interscapular region, inframammary area and abdomen. In a 15-year-old girl diagnosed with confluent and reticulated papillomatosis, the lesions first appeared on her knees and elbows when she was 4-years-old, and on the interscapular area when she was 13. Similar lesions arose on the left hand a few weeks previous to her visit. Two biopsy specimens were taken from the interscapular and elbow areas. The histopathological findings of this case fit the diagnosis of confluent and reticulated papillomatosis. We expect good results from azithromycin therapy.

Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Female; Humans; Papilloma; Skin Neoplasms

Topics: Adult; Anti-Bacterial Agents; Azithromycin; Humans; Hyperpigmentation; Male; Papilloma; Siblings; Skin Neoplasms; Treatment Outcome

Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Azithromycin; Back; Humans; Male; Papilloma; Skin Neoplasms; Treatment Outcome

The histologic findings of confluent and reticulated papillomatosis include papillomatosis, hyperkeratosis, and minimal or no acanthosis. We present a patient with the clinical findings of confluent and reticulated papillomatosis who responded dramatically to azithromycin, but histologic examination did not reveal papillomatosis. We observed invagination of basket-weave hyperkeratosis through the epidermis. We considered this finding may give a clue for the diagnosis of confluent and reticulated papillomatosis.

Topics: Acanthosis Nigricans; Adolescent; Anti-Bacterial Agents; Azithromycin; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Keratosis; Neoplasm Staging; Papilloma; Skin Neoplasms

Confluent and reticulated papillomatosis (CRP) is a relatively rare disorder of unknown origin, mostly affecting young female adults. We here present the case of a 21-year-old male patient with confluent and reticulated papillomatosis. Skin examination revealed brownish, verrucous, hyperkeratotic, 2 to 5 mm papules, which formed confluent patches and plaques with a reticulate network on the interscapular area. The patient was initially treated with ketoconazole cream for two weeks without improvement. The disease can be rather persistent and resistant to topical therapy. Our case showed a satisfactory response to treatment with azithromycin. Although this treatment is known to be effective in some cases, the action mechanism of azithromycin on CRP is not fully understood.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Azithromycin; Diagnosis, Differential; Humans; Male; Papilloma; Skin Neoplasms

Topics: Azithromycin; Biopsy; Diagnosis, Differential; Humans; Papilloma; Prurigo; Skin; Skin Neoplasms; Syndrome

Confluent and reticulated papillomatosis is a fairly rare dermatosis of still unknown origin affecting mostly female young adults. The lesions are mainly localized in the midline of the trunk. Systemic treatment is the treatment of choice because the disease is resistant to topical therapy and recurrences are often seen. In recent publications retinoids and minocycline have been reported as the favourite therapeutic approaches. We successfully treated a 19-year-old-girl with azithromycin resulting in a complete healing of all skin lesions. The patient has been free of disease for five months. Based on our own case and data in literature, azithromycin is an effective, reasonable and safe therapeutic alternative.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Azithromycin; Biopsy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Papilloma; Skin; Skin Neoplasms; Time Factors

Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Humans; Male; Papilloma; Skin Neoplasms

Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Female; Humans; Papilloma; Skin Neoplasms