zithromax and Skin-Diseases

Sarcoidosis is a chronic granulomatous disease for which there are limited therapeutic options. This is the first randomized, placebo-controlled study to demonstrate that antimycobacterial therapy reduces lesion diameter and disease severity among patients with chronic cutaneous sarcoidosis.. To evaluate the safety and efficacy of once-daily antimycobacterial therapy on the resolution of chronic cutaneous sarcoidosis lesions.. A randomized, placebo-controlled, single-masked trial on 30 patients with symptomatic chronic cutaneous sarcoidosis lesions deemed to require therapeutic intervention.. A tertiary referral dermatology center in Nashville, Tennessee.. Participants were randomized to receive either the oral concomitant levofloxacin, ethambutol, azithromycin, and rifampin (CLEAR) regimen or a comparative placebo regimen for 8 weeks with a 180-day follow-up.. Participants were monitored for absolute change in lesion diameter and decrease in granuloma burden, if present, on completion of therapy.. In the intention-to-treat analysis, the CLEAR-treated group had a mean (SD) decrease in lesion diameter of -8.4 (14.0) mm compared with an increase of 0.07 (3.2) mm in the placebo-treated group (P = .05). The CLEAR group had a significant reduction in granuloma burden and experienced a mean (SD) decline of -2.9 (2.5) mm in lesion severity compared with a decline of -0.6 (2.1) mm in the placebo group (P = .02).. Antimycobacterial therapy may result in significant reductions in chronic cutaneous sarcoidosis lesion diameter compared with placebo. These observed reductions, associated with a clinically significant improvement in symptoms, were present at the 180-day follow-up period. Transcriptome analysis of sarcoidosis CD4+ T cells revealed reversal of pathways associated with disease severity and enhanced T-cell function following T-cell receptor stimulation.. clinicaltrials.gov Identifier: NCT01074554.

Topics: Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Azithromycin; CD4-Positive T-Lymphocytes; Chronic Disease; Drug Therapy, Combination; Ethambutol; Female; Follow-Up Studies; Humans; Levofloxacin; Male; Middle Aged; Ofloxacin; Rifampin; Sarcoidosis; Severity of Illness Index; Single-Blind Method; Skin Diseases; Transcriptome; Treatment Outcome; Young Adult

Antibiotic prophylaxis for the prevention of surgical wounds infections is still a matter of debate in dermatology. The authors have performed an open and randomized study on the prophylactic efficacy of azithromycin, 500 mg per os 1 h prior to the procedure in a dermosurgical office. The absence of postsurgical infections when the intervention has been executed in sites without risk of contamination both in the treated and no treated group, has demonstrated that, in the presence of correct prophylactic measures, no antibiotic prophylaxis is necessary. On the other hand, when the procedure has been performed in sites under risk of infection, the antibiotic prophylaxis has instead demonstrated a significant efficacy. The study has documented that azithromycin allows to efficacely prevent bacterical suprainfection with a good compliance of the patient in the cases in which dermosurgical activity is performed in sites with risk of infection (face, scalp, genitals, perineo, feet).

Topics: Adult; Aged; Ambulatory Surgical Procedures; Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Female; Humans; Male; Middle Aged; Skin Diseases

In the present study, we reported the natural infection by Leishmania sp. in a domestic cat, in which the amastigote forms of the parasite were observed within a lesion on its ear-tip. Fragment of the lesion was obtained and cultured in NNN medium, and PCR-RFLP analysis of the isolated sample was performed, which revealed that the profile was compatible with Leishmania (L.) amazonensis. This is the first proven case of a cat infected by L. (L.) amazonensis reported in Belém city, Pará state, northern Brazil.

Topics: Allopurinol; Animals; Azithromycin; Brazil; Cat Diseases; Cats; Diagnosis, Differential; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Skin Diseases; Trypanocidal Agents

Topics: Azithromycin; Child; Female; Humans; Methylprednisolone; Mucositis; Mycoplasma; Pneumonia, Mycoplasma; Skin Diseases; Stevens-Johnson Syndrome; Treatment Outcome

Rosacea is a common chronic cutaneous disorder that primarily occurs on the convex surfaces of the central face and is often characterized by exacerbations and remissions. A case of a 52-yr-old woman visited our clinic in February 2008 complaining typical features of rosacea including multiple pinhead to rice-sized erythematous papules. We applied various conventional treatments including topical benzoyl peroxide and metronidazole as well as oral metronidazole, isotretinoin, and doxycycline. The lesions were not controlled but were rather aggravated by complications from these treatments. Therefore, we prescribed oral azithromycin, which has anti-inflammatory effects and reduces reactive oxygen species. Ten weeks after the administration of oral azithromycin, 500 mg per day for 2 weeks, the lesions had mostly disappeared and no specific side effects related to the azithromycin were noted. Oral azithromycin dosing 500 mg/day for 2 weeks is effective for treatment of intractable rosacea.

Topics: Administration, Oral; Azithromycin; Erythema; Female; Humans; Middle Aged; Reactive Oxygen Species; Rosacea; Skin Diseases

Topics: Anti-Bacterial Agents; Azithromycin; Child; Humans; Male; Skin Diseases; Tonsillitis; Vasculitis, Leukocytoclastic, Cutaneous

The ability of azithromycin, erythromycin, clarithromycin, or cefuroxime to modify the course of group A streptococcus (GAS) or Staphylococcus aureus soft-tissue infection was compared in a mouse model. In GAS-infected mice given azithromycin, fewer demonstrated dermonecrosis (P = 0.0004); the average weight gain was greater (P < 0.05) and the latency to sustained weight gain was shorter (P < 0.05) than for animals given other antibiotics. All antibiotics were effective against S. aureus infections, with no significant differences among treatments in parameters evaluated. The effectiveness of azithromycin in GAS-infected mice may be related to the high and sustained tissue concentrations achieved with this antibiotic.

Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Azithromycin; Cefuroxime; Clarithromycin; Disease Models, Animal; Erythromycin; Fasciitis, Necrotizing; Mice; Mice, Hairless; Skin Diseases; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pyogenes