zithromax and Papilloma

Azithromycin, an azalide subclass macrolide antibiotic, is an effective, well-tolerated and safe therapeutic option for treatment of papillomatosis in humans. This study reports the clinical and histopathological results from a prospective, randomized, double-blinded, placebo-controlled trial of 17 dogs of various breeds with diagnosis of oral (n = 12) and cutaneous papillomatosis (n = 5) treated with azithromycin. Papillomas appeared as whitish, verrucous, hyperkeratotic papules 1-2.7 mm in size. The cases were randomly assigned to azithromycin (n = 10) and placebo treatment groups (n = 7). Both owners and investigators were blinded to the allocation to the groups. Azithromycin (10 mg/kg) was administered per os every 24 h for 10 days. Clinical evaluations were done by the same investigator throughout the trial. Azithromycin treatment significantly decreased clinical scores (P < 0.001), whereas there was no change seen in the placebo group. In the azithromycin treatment group, skin lesions disappeared in 10-15 days. One case in the placebo had spontaneous regression of its papillomas by day 41, but lesions were still evident at day 50 in the remaining six cases. There was no recurrence of papillomatosis in the azithromycin treated dogs (follow up 8 months). No adverse effects were seen in either group. In conclusion, azithromycin appears to be a safe and effective treatment for canine papillomatosis.

Topics: Animals; Anti-Bacterial Agents; Azithromycin; Dog Diseases; Dogs; Double-Blind Method; Papilloma

Topics: Azithromycin; Biopsy, Needle; Dermatitis; Follow-Up Studies; Humans; Immunohistochemistry; Male; Papilloma; Precancerous Conditions; Prurigo; Risk Assessment; Skin Neoplasms; Young Adult

Topics: Animals; Anti-Bacterial Agents; Azithromycin; Dog Diseases; Dogs; Papilloma

Confluent and reticulated papillomatosis is a relatively rare dermatosis of unknown origin. It is characterized by papules that become confluent in the center and reticulated at the periphery. The sites of predilection are the neck, interscapular region, inframammary area and abdomen. In a 15-year-old girl diagnosed with confluent and reticulated papillomatosis, the lesions first appeared on her knees and elbows when she was 4-years-old, and on the interscapular area when she was 13. Similar lesions arose on the left hand a few weeks previous to her visit. Two biopsy specimens were taken from the interscapular and elbow areas. The histopathological findings of this case fit the diagnosis of confluent and reticulated papillomatosis. We expect good results from azithromycin therapy.

Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Female; Humans; Papilloma; Skin Neoplasms

Topics: Adult; Anti-Bacterial Agents; Azithromycin; Humans; Hyperpigmentation; Male; Papilloma; Siblings; Skin Neoplasms; Treatment Outcome

Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Azithromycin; Back; Humans; Male; Papilloma; Skin Neoplasms; Treatment Outcome

The histologic findings of confluent and reticulated papillomatosis include papillomatosis, hyperkeratosis, and minimal or no acanthosis. We present a patient with the clinical findings of confluent and reticulated papillomatosis who responded dramatically to azithromycin, but histologic examination did not reveal papillomatosis. We observed invagination of basket-weave hyperkeratosis through the epidermis. We considered this finding may give a clue for the diagnosis of confluent and reticulated papillomatosis.

Topics: Acanthosis Nigricans; Adolescent; Anti-Bacterial Agents; Azithromycin; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Keratosis; Neoplasm Staging; Papilloma; Skin Neoplasms

Confluent and reticulated papillomatosis (CRP) is a relatively rare disorder of unknown origin, mostly affecting young female adults. We here present the case of a 21-year-old male patient with confluent and reticulated papillomatosis. Skin examination revealed brownish, verrucous, hyperkeratotic, 2 to 5 mm papules, which formed confluent patches and plaques with a reticulate network on the interscapular area. The patient was initially treated with ketoconazole cream for two weeks without improvement. The disease can be rather persistent and resistant to topical therapy. Our case showed a satisfactory response to treatment with azithromycin. Although this treatment is known to be effective in some cases, the action mechanism of azithromycin on CRP is not fully understood.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Azithromycin; Diagnosis, Differential; Humans; Male; Papilloma; Skin Neoplasms

Topics: Azithromycin; Biopsy; Diagnosis, Differential; Humans; Papilloma; Prurigo; Skin; Skin Neoplasms; Syndrome

Confluent and reticulated papillomatosis is a fairly rare dermatosis of still unknown origin affecting mostly female young adults. The lesions are mainly localized in the midline of the trunk. Systemic treatment is the treatment of choice because the disease is resistant to topical therapy and recurrences are often seen. In recent publications retinoids and minocycline have been reported as the favourite therapeutic approaches. We successfully treated a 19-year-old-girl with azithromycin resulting in a complete healing of all skin lesions. The patient has been free of disease for five months. Based on our own case and data in literature, azithromycin is an effective, reasonable and safe therapeutic alternative.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Azithromycin; Biopsy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Papilloma; Skin; Skin Neoplasms; Time Factors

Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Humans; Male; Papilloma; Skin Neoplasms

Topics: Adolescent; Anti-Bacterial Agents; Azithromycin; Female; Humans; Papilloma; Skin Neoplasms