zithromax and Metabolic-Diseases

Obesity, a metabolic disease caused by multiple factors, has become a global health problem. In addition to nutrient intake and sedentary lifestyle, environmental pollutants exposure has been shown to be involved in obesity epidemics. Antibiotics, a new type of environmental pollutant, have been widely used in animal husbandry, aquaculture and microorganism. However, the effects of antibiotics exposure on fat metabolism and metabolic diseases are largely unknown.

Topics: Adipose Tissue, Beige; Animals; Anti-Bacterial Agents; Azithromycin; Humans; Metabolic Diseases; Mice; Obesity; Rodentia

Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.. The study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder. Three-week-old mice were treated with AZT (50 mg/kg/day). Taken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome.

Topics: Animals; Anti-Bacterial Agents; Azithromycin; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Diet, High-Fat; Disease Models, Animal; Disease Susceptibility; Glucose Tolerance Test; Glycolipids; Inflammation Mediators; Lipid Metabolism; Male; Metabolic Diseases; Mice; Plant Extracts; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization