zithromax and Jaundice

Drug-induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. There is currently no biomarker that is helpful in diagnosis which relies on clinical and laboratory findings. Diagnosis is dependent on temporal relationship with a recently started drug or herbal and dietary supplement and elevated liver tests with exclusion of competing etiologies. The implicated agent should be discontinued and the patient should be observed closely. This is particularly important in patients with jaundice who have approximately 10% risk of liver related mortality and/or need for liver transplantation. There is no specific therapy for DILI which is only symptomatic such as for itching. Patients with jaundice and coagulopathy usually require hospitalization.

Topics: Acetylcysteine; Aged; Anti-Bacterial Agents; Anticholesteremic Agents; Atorvastatin; Azithromycin; Checklist; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Middle Aged; Pruritus; Symptom Assessment

Topics: Aged; Anemia; Anti-Infective Agents; Atovaquone; Azithromycin; Babesiosis; Electrocardiography; Fatigue; Fever; Humans; Jaundice; Male; Reticulocyte Count; Thrombocytopenia

Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Azithromycin; Diarrhea; Drug Administration Schedule; Fatigue; Female; Humans; Jaundice; Liver; Respiratory Tract Infections

Topics: Adult; Anti-Bacterial Agents; Anticholesteremic Agents; Azithromycin; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Cholestyramine Resin; Female; Humans; Jaundice; Plasmapheresis