zithromax and Fusobacterium-Infections

An 18-year-old woman presented to clinic with acute pharyngitis with 4/4 Centor criteria. Rapid streptococcal antigen test was negative. The patient, who was allergic to penicillin, was prescribed azithromycin. Ultimately, after 5 days and without any corticosteroids, she presented to the emergency department with 10/10 chest pain and was admitted to the intensive care unit. CT showed nodular lung disease and blood cultures on admission grew

Topics: Acute Disease; Adolescent; Anti-Bacterial Agents; Azithromycin; Chest Pain; Drug Resistance, Bacterial; Female; Fusobacterium; Fusobacterium Infections; Heart Arrest; Humans; Lemierre Syndrome; Pharyngitis

Trueperella pyogenes is one of the most important microorganisms causing metritis in post-partum cattle. Co-infection with other bacterial species such as Escherichia coli or Fusobacterium necrofurom increases the severity of the disease and the persistence of bacteria in utero. The aim of this study was to investigate the frequency of T. pyogenes strains, and their virulence and antimicrobial resistant profiles in metritis cases. The study was carried out on 200 samples obtained from metritis discharges of postpartum cattle on 18 farms around Tehran, Iran. Sixty-five T. pyogenes isolates (32.5%) were identified, of which 16 isolates were detected as pure cultures and the other 49 isolates from cultures most commonly mixed with E. coli or F. necrofurom. In terms of diversity in biochemical characteristic of T. pyogenes strains, 8 different biotypes were identified among the isolates. Single or multi antimicrobial resistance was observed in 48 isolates (73.9%), which was mostly against trimethoprim sulfamethoxazole, azithromycin, erythromycin and streptomycin. The tetracycline resistance gene tetW and macrolide resistance genes ermB and ermX were detected in 30, 18 and 25 isolates, respectively. In the screening of genes encoding virulence factors, fimA and plo genes were identified in all tested isolates. Genes encoding nanP, nanH, fimC, fimG, fimE and cbpA were detected in 50, 54, 45, 40, 50 and 37 of isolates, respectively. Thirteen different genotypes were observed in these T. pyogenes isolates. A significant association between clonal types and virulence factor genes, biochemical profile, CAMP test result, severity of the disease and sampling time was detected.

Topics: Actinomycetaceae; Actinomycetales Infections; Animals; Anti-Bacterial Agents; Azithromycin; Bacterial Typing Techniques; Cattle; Clone Cells; Drug Resistance, Multiple, Bacterial; Erythromycin; Escherichia coli; Escherichia coli Infections; Female; Fusobacterium; Fusobacterium Infections; Genes, Bacterial; Iran; Parturition; Puerperal Infection; Streptomycin; Trimethoprim, Sulfamethoxazole Drug Combination; Uterus; Virulence Factors

Oral necrobacillosis or lumpy jaw is a common cause of morbidity and mortality affecting captive macropods. This article describes several cases of a new treatment regimen using a sustained release chlorhexidine varnish applied locally to the teeth and the gingivae of two Macropus species, eastern grey kangaroos (Macropus gigantus) from Gan-Garoo Australian Park and a red-necked wallaby (Macropus rufogriseus fruticus) from The Tisch Family Zoological Gardens in Jerusalem. The varnish was applied using a horsehair paint brush as three 1- to 2-mm thick layers. The active ingredient in the varnish was the disinfectant chlorhexidine. Results indicated that use of an intraoral sustained release varnish significantly shortens the treatment time and may prevent recurrence.

Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Azithromycin; Chlorhexidine; Delayed-Action Preparations; Female; Fusobacterium Infections; Macropodidae; Male; Paint