zithromax and Corneal-Neovascularization

zithromax has been researched along with Corneal-Neovascularization* in 2 studies

Other Studies

2 other study(ies) available for zithromax and Corneal-Neovascularization

Article	Year
Severe rosacea in a child. Journal francais d'ophtalmologie, 2020, Volume: 43, Issue:4 Topics: Administration, Oral; Administration, Topical; Adolescent; Azithromycin; Chalazion; Child; Conjunctivitis; Corneal Neovascularization; Dexamethasone; Doxycycline; Drug Therapy, Combination; Female; Humans; Rosacea	2020
Effect of topical azithromycin on corneal innate immune responses. Investigative ophthalmology & visual science, 2011, Apr-19, Volume: 52, Issue:5 To determine the effect of azithromycin (AZM) in a murine model of corneal inflammation.. The effect of topical AZM was studied in murine corneal inflammation. Corneal inflammation was induced by thermal cautery in BALB/c mice. Leukocyte infiltration at different time points was analyzed by flow cytometry. At set time points, real-time polymerase chain reaction was performed to quantify the expression of different inflammatory cytokine transcript in the cornea. Corneal samples were analyzed immunohistochemically for the expression of intercellular adhesion molecule-1 (ICAM-1). Corneal neovascularization (CNV) was induced by micropellet (VEGF-A) placement. Mice were then treated topically with either AZM or vehicle. CNV was evaluated morphometrically.. Eyes receiving AZM showed a significant decrease in corneal infiltration compared with the vehicle-treated group. AZM also significantly decreased messenger RNA expression levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and ICAM-1 in the cornea. There was no significant difference in CNV between the AZM- and vehicle-treated groups.. After an inflammatory insult, topical AZM significantly reduced leukocyte infiltration into the cornea. This was further supported by an associated decrease in expression of IL-1β, TNF-α, and ICAM-1 in the cornea, indicating AZM may have a potential anti-inflammatory effect on corneal inflammation. Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Azithromycin; Cell Movement; Cornea; Corneal Neovascularization; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression; Immunity, Innate; Intercellular Adhesion Molecule-1; Interleukin-1beta; Keratitis; Leukocytes; Male; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha	2011

Article

Year

Journal francais d'ophtalmologie, 2020, Volume: 43, Issue:4

Topics: Administration, Oral; Administration, Topical; Adolescent; Azithromycin; Chalazion; Child; Conjunctivitis; Corneal Neovascularization; Dexamethasone; Doxycycline; Drug Therapy, Combination; Female; Humans; Rosacea

2020

Effect of topical azithromycin on corneal innate immune responses.

Investigative ophthalmology & visual science, 2011, Apr-19, Volume: 52, Issue:5

To determine the effect of azithromycin (AZM) in a murine model of corneal inflammation.. The effect of topical AZM was studied in murine corneal inflammation. Corneal inflammation was induced by thermal cautery in BALB/c mice. Leukocyte infiltration at different time points was analyzed by flow cytometry. At set time points, real-time polymerase chain reaction was performed to quantify the expression of different inflammatory cytokine transcript in the cornea. Corneal samples were analyzed immunohistochemically for the expression of intercellular adhesion molecule-1 (ICAM-1). Corneal neovascularization (CNV) was induced by micropellet (VEGF-A) placement. Mice were then treated topically with either AZM or vehicle. CNV was evaluated morphometrically.. Eyes receiving AZM showed a significant decrease in corneal infiltration compared with the vehicle-treated group. AZM also significantly decreased messenger RNA expression levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and ICAM-1 in the cornea. There was no significant difference in CNV between the AZM- and vehicle-treated groups.. After an inflammatory insult, topical AZM significantly reduced leukocyte infiltration into the cornea. This was further supported by an associated decrease in expression of IL-1β, TNF-α, and ICAM-1 in the cornea, indicating AZM may have a potential anti-inflammatory effect on corneal inflammation.

Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Azithromycin; Cell Movement; Cornea; Corneal Neovascularization; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression; Immunity, Innate; Intercellular Adhesion Molecule-1; Interleukin-1beta; Keratitis; Leukocytes; Male; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

2011