zithromax and Cholestasis--Intrahepatic

Topics: Aged; Anti-Bacterial Agents; Azithromycin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Male

Azithromycin-induced liver injury has been rarely reported in adult individuals, let alone in a pregnant woman. Here, we describe the clinical features and outcomes of azithromycin-induced liver injury in a pregnant woman.. A 30-year-old pregnant woman presented with generalized pruritus and elevated serum bile acid level (123.6 μmol/L) on day 4 of azithromycin administration. A diagnosis of intrahepatic cholestasis of pregnancy was made, and cesarean section was performed immediately. Interestingly, the alanine aminotransferase level (ALT) reached 211.2 U/L on day 9 after azithromycin administration.. Therefore, drug-induced intrahepatic cholestasis was considered.. (1) Azithromycin withdrawal after the patient hospitalized. (2) Termination of pregnancy by cesarean section was performed inmmediately to protect the fetus. (3) Silymarin capsules and bifendate are used to protect the liver after liver enzymes elevation was discovered.. The liver enzymes recovered within 4 weeks without any symptoms after treatment with silymarin capsules and bifendate, which helps reduce ALT level and protects the liver from further injury.. A pregnant woman developed azithromycin-induced intrahepatic cholestasis. Physicians should be aware of this side effect of azithromycin, which is widely prescribed.

Topics: Adult; Anti-Bacterial Agents; Azithromycin; Cesarean Section; Cholestasis, Intrahepatic; Female; Humans; Pregnancy; Pregnancy Complications

Azithromycin (Zithromax), an erythromycin derivative that belongs to a subgroup of the macrolides known as azolides, has generally been considered to be a very safe medication. Hepatic side effects are uncommon but may include jaundice, fever, and right upper quadrant pain. Herein we describe a patient who developed azithromycin-induced cholestatic hepatitis that resolved upon discontinuation of the drug. Lack of other known causes for liver disease, the temporal relationship with this drug, and the typical changes of liver histology have established the diagnosis. Clinicians should be aware of this side effect of azithromycin, which is widely prescribed.

Topics: Aged; Anti-Bacterial Agents; Azithromycin; Biopsy, Needle; Cholestasis, Intrahepatic; Humans; Liver; Liver Function Tests; Male; Respiratory Tract Infections

Topics: Acute Disease; Anti-Bacterial Agents; Azithromycin; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Middle Aged

Topics: Acute Disease; Aged; Anti-Bacterial Agents; Azithromycin; Cholestasis, Intrahepatic; Humans; Male