zithromax and Acidosis

zithromax has been researched along with Acidosis* in 1 studies

Other Studies

1 other study(ies) available for zithromax and Acidosis

ArticleYear
Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.
    British journal of pharmacology, 2022, Volume: 179, Issue:11

    Hydroxychloroquine, chloroquine and azithromycin are three drugs that were proposed to treat coronavirus disease 2019 (COVID-19). While concern already existed around their proarrhythmic potential, there are little data regarding how altered physiological states encountered in patients such as febrile state, electrolyte imbalances or acidosis might change their risk profiles.. Potency of human ether-à-go-go related gene (hERG) block was measured using high-throughput electrophysiology in the presence of variable environmental factors. These potencies informed simulations to predict population risk profiles. Effects on cardiac repolarisation were verified in human induced pluripotent stem cell-derived cardiomyocytes from multiple individuals.. Chloroquine and hydroxychloroquine blocked hERG with IC. Our study demonstrates how proarrhythmic risk can be exacerbated by metabolic changes and pre-existing disease. More broadly, the study acts as a blueprint for how high-throughput in vitro screening, combined with in silico simulations, can help guide both preclinical screening and clinical management of patients in relation to drugs with potential to prolong repolarisation.

    Topics: Acidosis; Azithromycin; Chloroquine; COVID-19 Drug Treatment; Female; Humans; Hydroxychloroquine; Hypokalemia; Induced Pluripotent Stem Cells; SARS-CoV-2

2022