zinostatin and Pulmonary-Fibrosis

zinostatin has been researched along with Pulmonary-Fibrosis* in 2 studies

Reviews

1 review(s) available for zinostatin and Pulmonary-Fibrosis

ArticleYear
Cytotoxic drug-induced pulmonary disease: update 1980.
    The American journal of medicine, 1980, Volume: 68, Issue:2

    Administration of a number of cytotoxic agents has been associated with interstitial pneumonitis, alveolitis and pulmonary fibrosis. Some (bleomycin, busulfan, methotrexate) are well known to cause this problem, and others (carmustine, semustine, zinostatin, mitomycin, and chlorambucil) have only recently been recognized to do so. We review and update the available information about this form of drug toxicity. Interaction between these drugs and thoracic radiation or high oxygen fractions in inspired air has produced pneumonitis at doses lower than when the drug is used alone. Synergism between the drugs themselves when given concurrently also produces pulmonary toxicity at lower doses. With some drugs and in some patients steroids will diminish the pulmonary abnormalities, but death from hypoxia is a frequent outcome. Since early recognition of the problem and withdrawal of the injurious agent is the best treatment, physician awareness of and alertness to this toxicity and its relative risk is most important. The discovery of analogs of bleomycin with a better therapeutic index, specifically reducing pulmonary damage, is one of the goals of current cancer drug development.

    Topics: Alkylating Agents; Antineoplastic Agents; Bleomycin; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Mercaptopurine; Methotrexate; Mitomycins; Nitrosourea Compounds; Procarbazine; Pulmonary Fibrosis; Zinostatin

1980

Other Studies

1 other study(ies) available for zinostatin and Pulmonary-Fibrosis

ArticleYear
Pulmonary reaction associated with neocarzinostatin therapy.
    Cancer treatment reports, 1978, Volume: 62, Issue:8

    Topics: Adult; Antibiotics, Antineoplastic; Humans; Male; Pulmonary Fibrosis; Zinostatin

1978