zinostatin and Pleural-Effusion

The oily anticancer agents dissolved in lipiodol used for arterial administration against various solid tumors in our department were found to be applicable to treat for pleural or peritoneal carcinomatosis experimentally and clinically. The pharmacokinetic study with rat model showed oily anticancer agents were retained in a high concentration in the peritoneal cavity compared to water-soluble anticancer agents. In our pilot clinical study all patients with pleural or peritoneal carcinomatosis showed improvement cytologically and physically.

Topics: Adult; Aged; Animals; Antibiotics, Antineoplastic; Ascitic Fluid; Carcinoma, Hepatocellular; Doxorubicin; Female; Furans; Humans; Infusions, Parenteral; Iodized Oil; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Maleic Anhydrides; Middle Aged; Pleural Effusion; Polystyrenes; Rats; Rats, Inbred Strains; Zinostatin

Neocarzinostatin (NCS) was administered intravenously by drop infusion to 16 patients with ovarian cancer, and intrathoracically to one patient. In addition to evaluation of the efficacy of the chemotherapy, we mainly investigated its effect on ascites and pleural effusion, and carried out continuous measurements of the abdominal circumference in 3 patients. NCS relieved thoracic effusion in 1 patient. We observed that abdominal circumference decreased in 10 patients after administration of NCS. The results obtained from continuous measurement of abdominal circumference revealed that NCS significantly reduced ascitic retention in ovarian cancer.

Topics: Adult; Aged; Antibiotics, Antineoplastic; Ascitic Fluid; Cisplatin; Female; Humans; Infusions, Intravenous; Middle Aged; Mitomycin; Mitomycins; Ovarian Neoplasms; Pleural Effusion; Zinostatin