zinostatin and Ovarian-Neoplasms

The purpose of this study is to evaluate the improved method of arterial infusion therapy of SMANCS (SX) with lipiodol under the angiotensin-induced hypertensive state for various difficult-to-treat solid tumors. Most patients were unresectable with no other therapeutic options, recurrence after resection, or patients do not respond to common treatments. The new method utilizes angiotensin II (AT) to induce hypertension (e.g. approximately 15-30 mmHg above norm) for 15-20 min. This method was successfully applied to metastatic liver cancer, cholangiocarcinoma, massive renal cell carcinoma, pancreatic and other abdominal solid cancers. This AT-induced hypertension resulted in remarkably enhanced tumor delivery accompanied by improved therapeutic response, and a shorter time to achieve 50% regression of tumor size with least toxicity. We demonstrated clinically herein improved therapy for various advanced solid tumors with SX by elevating the tumor blood flow selectively. This is the first clinical proof that modulations of vascular pathophysiology can uniquely accomplish enhanced tumor selective delivery of polymeric drugs and thus yielded better clinical outcome.

Topics: Adenocarcinoma; Adult; Aged; Angiotensin II; Antineoplastic Agents; Blood Pressure; Carcinoma, Renal Cell; Cholangiocarcinoma; Drug Delivery Systems; Female; Humans; Hypertension; Infusions, Intravenous; Japan; Kidney Neoplasms; Liver Neoplasms; Male; Maleic Anhydrides; Middle Aged; Neoplasm Staging; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Polystyrenes; Vasoconstrictor Agents; Zinostatin

Neocarzinostatin (NCS) was administered intravenously by drop infusion to 16 patients with ovarian cancer, and intrathoracically to one patient. In addition to evaluation of the efficacy of the chemotherapy, we mainly investigated its effect on ascites and pleural effusion, and carried out continuous measurements of the abdominal circumference in 3 patients. NCS relieved thoracic effusion in 1 patient. We observed that abdominal circumference decreased in 10 patients after administration of NCS. The results obtained from continuous measurement of abdominal circumference revealed that NCS significantly reduced ascitic retention in ovarian cancer.

Topics: Adult; Aged; Antibiotics, Antineoplastic; Ascitic Fluid; Cisplatin; Female; Humans; Infusions, Intravenous; Middle Aged; Mitomycin; Mitomycins; Ovarian Neoplasms; Pleural Effusion; Zinostatin

A 46-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy for a granulosa cell tumor of the ovary ten years ago. Six years later, she underwent a resection of the retroperitoneal tumor because of a retroperitoneal metastases of the ovarian tumor. Four years after, a second operation was carried out for a solitary metastasis on the surface of the liver of the right subphrenic space. It proved to be a disseminated metastasis from the ovarian tumor. The angiography showed that the tumor was being fed by the hepatic artery and, one month later, the tumor was resected. Such a case history of a disseminated solitary metastasis is very rare and seldom reported in the literature.

Topics: Combined Modality Therapy; Female; Granulosa Cell Tumor; Humans; Hysterectomy; Infusions, Intra-Arterial; Liver Neoplasms; Maleic Anhydrides; Middle Aged; Neoplastic Cells, Circulating; Ovarian Neoplasms; Polystyrenes; Zinostatin