zinostatin has been researched along with Lymphoma* in 3 studies
3 other study(ies) available for zinostatin and Lymphoma
| Article | Year |
|---|---|
[Treatment of meningeal carcinomatosis--neocarzinostatin perfusion therapy in the CSF pathway].
The authors presented the results of perfusion chemotherapy in the CSF pathway with neocarzinostatin (NCS) for the treatment of meningeal carcinomatosis. In three cases of stomach cancer and one case of malignant lymphoma, cranial polyneuropathy, progressive hydrocephalus and positive cytology of the CSF were found during treatment of malignant tumors. NCS therapy was performed by means of perfusion from the spinal subarachnoid space to the ventricle utilizing Ommaya's reservoir, or simply by repeated lumbar punctures. In all of four cases the number of malignant cells in the CSF was significantly diminished, and temporary neurological improvement was observed until the patient's death due to advanced primary lesions. These results indicated that in cases of meningeal carcinomatosis, NCS perfusion therapy using the CSF pathway was a much more favorable method than treatment with other chemotherapeutic agents with less noticeable side effects. Topics: Adult; Aged; Antibiotics, Antineoplastic; Cerebral Ventricles; Female; Humans; Lymphoma; Male; Meningitis; Middle Aged; Perfusion; Stomach Neoplasms; Subarachnoid Space; Zinostatin | 1985 |
Apurinic/apyrimidinic endonuclease sensitive sites as intermediates in the in vitro degradation of deoxyribonucleic acid by neocarzinostatin.
Neocarzinostatin (NCS) induces alkali-labile sites in DNA which are stabilized by NaBH4 reduction. The stabilized sites are sensitive to an AP endonuclease from human lymphoma cells. NCS-induced degradation of supercoiled Col E1 DNA proceeds in stepwise fashion with apurinic/apyrimidinic (AP) sites as intermediates. Degradation is increased when reaction occurs in the presence of AP endonuclease, and DNA reacted with NCS can be shown to have numerous AP endonuclease sensitive sites. Topics: Antibiotics, Antineoplastic; Cell Line; Deoxyribonuclease IV (Phage T4-Induced); Deoxyribonucleases; DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Superhelical; DNA, Viral; Endonucleases; Humans; Lymphoma; Neoplasms, Experimental; Polydeoxyribonucleotides; T-Phages; Zinostatin | 1980 |
Clinical and experimental studies on immunotherapy in malignant lymphoma.
Topics: Antibiotics, Antineoplastic; Humans; Immunoglobulin G; In Vitro Techniques; Leukemia, Lymphoid; Lymphoma; Picibanil; Zinostatin | 1978 |