zinc-66-atom and Brain-Neoplasms

The most common and aggressive primary malignancy of the central nervous system is Glioblastoma that, as a wide range of malignant solid tumor, is characterized by extensive hypoxic regions. A great number of PET radiopharmaceuticals have been developed for the identification of hypoxia in solid tumors, among these, we find copper-based tracers. The aim of the current review paper was to provide an overview of radiocopper compounds applied for preclinical and clinical research in brain tumors and hypoxia imaging or therapy.. Copper offers a wide variety of isotopes, useful for nuclear medicine applications, but only. In order to better understand the application of copper-bis thiosemicarbazones in hypoxia imaging, an overview of the role of hypoxia in cancer, existing non-imaging and imaging techniques for hypoxia identification and promising future avenues regarding hypoxia is necessary. Different proposed uptake mechanisms of [

Topics: Animals; Brain Neoplasms; Coordination Complexes; Copper Radioisotopes; Humans; Hypoxia; Isotopes; Nickel; Positron-Emission Tomography; Radionuclide Imaging; Radiopharmaceuticals; Structure-Activity Relationship; Thiosemicarbazones; Zinc Isotopes