zinc(ii)-phthalocyanine-trisulfonic-acid and Neoplasms

Lacking blood vessels is one of the main characteristics of most solid tumors due to their rapid and unrestricted growth, which thus causes the inefficient delivery efficiency of nanomedicine and tumor hypoxia. Herein, a dual "unlocking" strategy to overcome these obstacles is proposed by combining engineered hybrid nanoparticles (named ZnPc@FOM-Pt) with dexamethasone (DXM). It is verified that pretreatment of tumors with DXM can increase intratumorally micro-vessel density (delivery "unlocking") to enhance the tumor delivery efficiency of ZnPc@FOM-Pt and decrease HIF-1α expression. Correspondingly, more Pt can catalyze tumor-overexpressed H

Topics: Cell Line, Tumor; Humans; Hypoxia; Immunotherapy; Nanomedicine; Nanoparticles; Neoplasms; Photochemotherapy; Tumor Hypoxia; Tumor Microenvironment

All-in-one nano theranostics integrating accurate diagnosis and combined therapy is promising for high-efficacy tumor treatment and receiving significant attention. In this study, we develop photo-controlled release liposomes with nucleic acid-triggered fluorescence and photoactivity for tumor imaging and synergistic antitumor therapy. Copper phthalocyanine as a photothermal agent is fused into lipid layers to prepare liposomes encapsulating cationic zinc phthalocyanine ZnPc(TAP)

Topics: Animals; Cell Line, Tumor; Delayed-Action Preparations; Doxorubicin; Liposomes; Mice; Nanoparticles; Neoplasms; Photochemotherapy

Switchable theranostics are of great interest for accurate tumor imaging and targeted therapy. Here, we develop smart engineering to construct nanostructured phthalocyanines self-assembled by amphiphilic zinc phthalocyanines (ZnPcs) and hydrophobic copper phthalocyanines (CuPcs) (ZnPc(PEG)

Topics: Cell Line, Tumor; Fluorescence; Humans; Neoplasms; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Phototherapy; Tumor Microenvironment; Zinc Compounds

Controlled drug release systems can enhance the safety and availability but avoid the side effect of drugs. Herein, the concept of DNA complementary base pairing rules in biology is used to design and prepare a photothermal-triggered drug release system. Adenine (A) modified polydopamine nanoparticles (A-PDA, photothermal reagent) can effectively bind with thymine (T) modified Zinc phthalocyanine (T-ZnPc, photosensitizer) forming A-PDA = T-ZnPc (PATP) complex based on A = T complementary base pairing rules. Similar to DNA, whose base pairing in double strands will break by heating, T-ZnPc can be effectively released from A-PDA after near infrared irradiation-triggered light-thermal conversion to obtain satisfactory photodynamic-photothermal synergistic tumor treatment. In addition, PDA can carry abundant Gd

Topics: Adenine; Animals; Base Pairing; Cell Line, Tumor; Combined Modality Therapy; Delayed-Action Preparations; DNA, Complementary; Drug Delivery Systems; Drug Liberation; Drug Synergism; Female; Humans; Hyperthermia, Induced; Indoles; Isoindoles; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Phototherapy; Polymers; Xenograft Model Antitumor Assays; Zinc Compounds

Topics: Animals; Cardiotoxicity; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Echocardiography; Humans; Indoles; Male; Mice; Mice, Inbred BALB C; Nanoconjugates; Neoplasms; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Polyglutamic Acid; Rats; Rats, Inbred WKY; Tissue Distribution

Sulfonated metallo phthalocyanines (MPcS(n)) are second generation photosensitizers advanced for photodynamic therapy of various medical applications. A series of ZnPcS(n) was demetallated and subsequently converted to the corresponding [(64)Cu]CuPcS(n) in 40-50% isolated yields and >98% radiochemical purities. Tumor-bearing mice were injected with the (64)Cu-labeled products and subjected to 3-h dynamic PET imaging studies. Biodistribution patterns showed characteristic differences between the various derivatives. Tumor uptake was detected only for the amphiphilic derivatives [(64)Cu]CuPcS(2) and [(64)Cu]CuPcS(3)C(6) (1-1.5%ID/g). The biological data suggest that PET imaging with [(64)Cu]CuPc can be used to establish structure-PDT efficacy relationships for Pc-based photosensitizers.

Topics: Animals; Copper Radioisotopes; Indoles; Isoindoles; Isotope Labeling; Mice; Neoplasms; Organometallic Compounds; Photosensitizing Agents; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution