zimeldine and Obesity

This paper reviews the evidence of serotoninergic mechanisms in human feeding by considering the effects of 5-HT agonists, precursors and receptor antagonists on hunger, food intake and weight change in normal volunteers, obese people and psychiatric patients. Although there is compelling evidence for a serotonin (5-HT) mechanism being involved, the paper highlights the considerable individual variation in response to pharmacological manipulation of 5-HT. Such variation may reflect differences in the bio-availability of the drugs used. Subtle psychological factors may also play a role in blurring the pharmacological evidence for 5-HT involvement in the highly complex activity of human feeding.

Topics: Amitriptyline; Antipsychotic Agents; Cyproheptadine; Diet; Feeding Behavior; Fenfluramine; Food Preferences; Humans; Hunger; Metergoline; Methysergide; Nervous System Physiological Phenomena; Obesity; Satiety Response; Serotonin; Synaptic Transmission; Tryptophan; Zimeldine

Topics: Adult; Antidepressive Agents; Appetite Depressants; Brompheniramine; Double-Blind Method; Female; Humans; Middle Aged; Obesity; Patient Compliance; Pyridines; Zimeldine