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zileuton and Innate Inflammatory Response

zileuton has been researched along with Innate Inflammatory Response in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (31.58)	18.2507
2000's	9 (23.68)	29.6817
2010's	15 (39.47)	24.3611
2020's	2 (5.26)	2.80

Authors

Authors	Studies
Kreft, AF; Musser, JH	1
Brideau, C; Chan, CC; Delorme, D; Desmarais, S; Dubé, D; Ducharme, Y; Ethier, D; Falgueyret, JP; Girard, Y; Grimm, E; Guay, J; Hamel, P; Jones, TR; Kwong, E; McAuliffe, M; McFarlane, CS; Piechuta, H; Riendeau, D; Roumi, M; Tagari, P; Young, RN	1
Greiner, C; Koeberle, A; Schubert-Zsilavecz, M; Werz, O; Wurglics, M; Zettl, H	1
Dai, Z; He, S; Lai, L; Li, K; Liu, Y; McClendon, CL; Meng, H; Shang, E; Zhang, X	1
Ambruosi, M; Belardo, C; Collarile, S; de Rosa, M; Dehm, F; Esposito, V; Filosa, R; Guida, F; Krauth, V; Maione, S; Massa, A; Peduto, A; Werz, O	1
Aidhen, IS; Doble, M; Ramanan, M; Sinha, S; Sudarshan, K	1
Banoglu, E; Bruno, F; D'Amico, M; De Rosa, M; Errico, S; Filosa, R; Fiorentino, A; Guida, F; Maione, S; Maisto, R; Mkrtchyan, AS; Nawrozkij, MB; Olgaç, A; Pace, S; Werz, O	1
Bilancia, R; Cantone, V; Cheung, SY; Esposito, L; Gerstmeier, J; Hanke, T; Koeberle, A; König, S; Liening, S; Pace, S; Rizza, R; Rossi, A; Roviezzo, F; Schubert-Zsilavecz, M; Schuster, D; Stuppner, H; Temml, V; Troisi, F; Werner, M; Werz, O	1
Doble, M; Manju, SL; Sinha, S	1
Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A	1
Bobál, P; Gazdová, M; Hošek, J; Jakubczyk, K; Landa, P; Leláková, V; Malaník, M; Oravec, M; Pailee, P; Pížová, H; Prachyawarakorn, V; Ren, G; Schuster, D; Šmejkal, K; Temml, V; Veselý, O; Zpurný, F	1
Alsabil, K; Bernardes, GJL; Bilancia, R; Bréard, D; Brunner, E; Cerqua, I; Dinh, CP; Garscha, U; Gerstmeier, J; Gollowitzer, A; Helesbeux, JJ; Jordan, PM; Koeberle, A; Loeser, K; Lorkowski, S; Marques, MC; Mosig, AS; Neukirch, K; Pace, S; Permann, S; Raasch, M; Richomme, P; Rodrigues, T; Rossi, A; Roviezzo, F; Schuster, D; Séraphin, D; Stuppner, H; Temml, V; Viault, G; Ville, A; Werz, O	1
Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z	1
Barrero, C; Li, JG; Merali, S; Praticò, D	1
Akyol, O; Huang, L; McBride, DW; Sherchan, P; Wang, Y; Zhang, JH	1
Domon, H; Isono, T; Kawabata, S; Kurosawa, M; Maekawa, T; Oda, M; Terao, Y; Yamaguchi, M	1
Bujalska-Zadrozny, M; Gasinska, E; Maslinski, S; Rzodkiewicz, P	1
Chen, CM; Liang, RS; Shi, SS; Tu, XK; Wang, CH; Yang, WZ; Zhang, HB	1
Anderson, GD; Cortes-Burgos, LA; Graneto, MJ; Happa, FA; Hardy, MM; Hu, G; Masferrer, JL; Muthian, S; Pufahl, RA; Settle, SL; Stewart, Z; Weir, DE; Zweifel, BS	1
Amghar, H; Bouloumié, A; Bourlier, V; Féral, CC; Filloux, C; Galitzky, J; Grimaldi, PA; Mothe-Satney, I; Neels, JG; Pons, C; Van Obberghen, E	1
da Silva, NG; Gonçalves, LR; Sampaio, SC	1
Glori, M; Hintz, KH; Welliver, RC	1
Britti, D; Chatterjee, PK; Cuzzocrea, S; Di Paola, R; Patel, NS; Sautebin, L; Thiemermann, C	1
Kulkarni, SK; Patil, CS; Singh, VP	1
Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X	1
Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Genovese, T; Mazzon, E; Muià, C; Rossi, A; Sautebin, L	1
Anderson, GD; Dufield, DR; Hardy, MM; Masferrer, JL; Pufahl, RA; Zweifel, BS	1
Butler, BD; Little, T	1
Bailie, MB; Carter, GW; Dahm, LJ; Harris, RR; Peters-Golden, M; Roth, RA	1
Cohn, J; Kaminsky, DA; Martin, RJ; Trudeau, JB; Wenzel, SE; Westcott, JY	1
Chabot-Fletcher, M; Chilton, FH; Fonteh, AN; Huang, L; Marshall, LA; Sung, CM; Winkler, JD	1
Bell, RL; Brooks, DW; Carter, GW; Hansen, R; Lanni, C; Malo, PE; Rubin, P; Stewart, AO	1
Medvedeff, ED; Nickerson-Nutter, CL	1
Andresen, CJ; Eggler, JF; Smith, WB; Turner, CR; Watson, JW	1
Smith, LJ	1
Jackson, SK; Larsen, JS	1
Drazen, JM	1
Crawley, GC; Foster, SJ; McMillan, RM; Spruce, KE; Walker, ER	1

Reviews

5 review(s) available for zileuton and Innate Inflammatory Response

Article	Year
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors. Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14 Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Eosinophils; Humans; Inflammation; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung Diseases; Neutrophils; Quinolines	1992
Inhibition of CoA-independent transacylase reduces inflammatory lipid mediators. Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23 Topics: Acyltransferases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Humans; Hydroxyurea; Imidazoles; Inflammation; Mast Cells; Monocytes; Neutrophils; Organophosphorus Compounds	1995
Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents. Archives of internal medicine, 1996, Oct-28, Volume: 156, Issue:19 Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Hydroxyurea; Indoles; Inflammation; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds	1996
Antileukotriene therapy for asthma. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1996, Dec-01, Volume: 53, Issue:23 Topics: Asthma; Humans; Hydroxyurea; Inflammation; Leukotrienes; Lipoxygenase Inhibitors	1996
New directions in asthma drug therapy. Hospital practice (1995), 1998, Feb-15, Volume: 33, Issue:2 Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chromones; Humans; Hydroxyurea; Indoles; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds	1998

Trials

1 trial(s) available for zileuton and Innate Inflammatory Response

Article	Year
Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:3 Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Inflammation; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Middle Aged	1995

Article

Year

Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.

American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:3

Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Inflammation; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Middle Aged

1995

Other Studies

32 other study(ies) available for zileuton and Innate Inflammatory Response

Article	Year
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18 Topics: Animals; Ascaris; Biological Availability; Bronchodilator Agents; Dogs; Dyspnea; Humans; Inflammation; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Molecular Structure; Naphthalenes; Nematode Infections; Pyridines; Rats; Recombinant Proteins; Saimiri; Sheep; Spodoptera; Transfection	1997
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24 Topics: Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Models, Chemical; Prostaglandin-E Synthases; Pyrimidines	2008
Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution. Journal of medicinal chemistry, 2016, 05-12, Volume: 59, Issue:9 Topics: Allosteric Site; Arachidonate 15-Lipoxygenase; Arachidonic Acid; Cell-Free System; Cyclooxygenase Inhibitors; Drug Discovery; Humans; Inflammation; Lipoxygenase Inhibitors	2016
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. European journal of medicinal chemistry, 2016, Jan-27, Volume: 108 Topics: Adult; Animals; Arachidonate 5-Lipoxygenase; Carrageenan; Dose-Response Relationship, Drug; Edema; Humans; Indoles; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Structure; Neutrophils; Structure-Activity Relationship	2016
Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins. European journal of medicinal chemistry, 2016, Nov-29, Volume: 124 Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cytokines; Dinoprostone; Free Radicals; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Inflammation; Isocoumarins; Kinetics; Leukotrienes; Lipoxygenase Inhibitors; Prostaglandins; RNA, Messenger	2016
Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. European journal of medicinal chemistry, 2018, Jul-15, Volume: 155 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Dose-Response Relationship, Drug; Edema; Humans; Indoles; Inflammation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Molecular Structure; Neutrophils; Prostaglandin-E Synthases; Structure-Activity Relationship	2018
Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E European journal of medicinal chemistry, 2018, Aug-05, Volume: 156 Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Benzenesulfonamides; Cells, Cultured; HEK293 Cells; Humans; Inflammation; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Molecular Docking Simulation; Prostaglandin-E Synthases; Sulfonamides	2018
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase. European journal of medicinal chemistry, 2018, Oct-05, Volume: 158 Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Molecular Docking Simulation; Structure-Activity Relationship; Thiazoles	2018
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. European journal of medicinal chemistry, 2019, Apr-01, Volume: 167 Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles	2019
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase. Journal of natural products, 2019, 07-26, Volume: 82, Issue:7 Topics: Cell Line; Enzyme Inhibitors; Humans; Inflammation; Lipoxygenases; NF-kappa B; Prenylation; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Stilbenes; Transcription Factor AP-1	2019
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15 Topics: Administration, Oral; Arachidonate 5-Lipoxygenase; Dose-Response Relationship, Drug; Drug Discovery; Humans; Inflammation; Lipoxygenase Inhibitors; Molecular Docking Simulation; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship; Vitamin E	2021
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. Aging, 2021, 04-20, Volume: 13, Issue:8 Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Disease Models, Animal; Humans; Hydroxyurea; Inflammation; Infusions, Intraventricular; Lipoxygenase Inhibitors; Male; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subarachnoid Hemorrhage	2021
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Scientific reports, 2017, 04-06, Volume: 7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Diet; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hydroxyurea; Inflammation; Lipoxygenase; Male; Mice, Transgenic; Phenotype; Phosphorylation; Synapses; tau Proteins; Up-Regulation; Vitamin B Complex; Vitamin B Deficiency	2017
Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation. Scientific reports, 2017, 07-14, Volume: 7, Issue:1 Topics: Animals; Arachidonate 5-Lipoxygenase; Biomarkers; Brain; Brain Edema; Brain Injuries; Elapid Venoms; Hydroxyurea; Inflammation; Intraoperative Complications; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Naja; Phospholipase A2 Inhibitors; Phospholipases A2; Rats; Signal Transduction; Skin; Subcutaneous Tissue; Terpenes	2017
Frontiers in cellular and infection microbiology, 2017, Volume: 7 Topics: Animals; Aorta; Arachidonic Acid; Aspirin; Cell Adhesion Molecules; DNA, Bacterial; Endothelial Cells; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Monocytes; Mutation; Phospholipases A2; Recombinant Proteins; Signal Transduction; Streptococcus pyogenes; THP-1 Cells; Vascular Cell Adhesion Molecule-1	2017
Antinociceptive properties of esculetin in non-inflammatory and inflammatory models of pain in rats. Clinical and experimental pharmacology & physiology, 2015, Volume: 42, Issue:2 Topics: Analgesia; Analgesics; Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Hyperalgesia; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pain; Pain Threshold; Rats; Umbelliferones	2015
5-LOX Inhibitor Zileuton Reduces Inflammatory Reaction and Ischemic Brain Damage Through the Activation of PI3K/Akt Signaling Pathway. Neurochemical research, 2016, Volume: 41, Issue:10 Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Brain Ischemia; Hydroxyurea; Infarction, Middle Cerebral Artery; Inflammation; Lipoxygenase Inhibitors; Male; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction	2016
CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain. European journal of pharmacology, 2009, Sep-01, Volume: 617, Issue:1-3 Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Humans; Hydroxyurea; Imidazoles; Immunohistochemistry; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Male; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Substrate Specificity; Sulfides	2009
Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes, 2012, Volume: 61, Issue:9 Topics: Adipocytes; Adipose Tissue; Animals; Arachidonate 5-Lipoxygenase; Cell Line; Chemokines; Cytokines; Diet, High-Fat; Female; Humans; Hydroxyurea; Inflammation; Insulin Resistance; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Obesity; Subcutaneous Fat	2012
Inhibitory effect of Crotalus durissus terrificus venom on chronic edema induced by injection of bacillus Calmette-Guérin into the footpad of mice. Toxicon : official journal of the International Society on Toxinology, 2013, Mar-01, Volume: 63 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BCG Vaccine; Chronic Disease; Crotalid Venoms; Crotalus; Crotoxin; Dexamethasone; Edema; Foot; Hindlimb; Hydroxyurea; Inflammation; Injections, Subcutaneous; Lipoxygenase; Male; Mice; Mycobacterium bovis	2013
Zileuton reduces respiratory illness and lung inflammation, during respiratory syncytial virus infection, in mice. The Journal of infectious diseases, 2003, Jun-01, Volume: 187, Issue:11 Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Hydroxyurea; Inflammation; Leukotriene Antagonists; Leukotrienes; Lung; Mice; Mice, Inbred BALB C; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Time Factors; Virus Replication; Weight Loss	2003
Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. Molecular pharmacology, 2004, Volume: 66, Issue:2 Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Ischemia; Kidney Diseases; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Mice, Knockout; Neutrophils; Peroxidase; Reperfusion Injury	2004
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats. Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3 Topics: Acetates; Acetic Acid; Analgesics; Animals; Capillary Permeability; Carrageenan; Cyclopropanes; Dose-Response Relationship, Drug; Female; Hindlimb; Hydroxyurea; Hyperalgesia; Indoles; Inflammation; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Mice; Pain; Pain Measurement; Phenylcarbamates; Quinolines; Rats; Rats, Wistar; Receptors, Leukotriene B4; Sulfides; Sulfonamides; Tosyl Compounds	2005
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; Dogs; Ear; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Female; Humans; Hydroxyurea; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxins; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neutrophil Infiltration; Peritonitis; Piperidines; Recombinant Proteins	2007
Effects of zileuton and montelukast in mouse experimental spinal cord injury. British journal of pharmacology, 2008, Volume: 153, Issue:3 Topics: Acetates; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclopropanes; Cysteine; Dinoprostone; Disease Models, Animal; Gene Expression Regulation; Hydroxyurea; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Neutrophil Infiltration; Quinolines; Recovery of Function; Spinal Cord Injuries; Sulfides; Tumor Necrosis Factor-alpha	2008
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1 Topics: Air; Animals; Arachidonate 5-Lipoxygenase; Biological Assay; Calcimycin; Carrageenan; Cell Line, Tumor; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyurea; Imidazoles; Immunoglobulin E; Inflammation; Ionophores; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Oxidation-Reduction; Rats; Rats, Inbred Lew; Reproducibility of Results; Sulfides; Tandem Mass Spectrometry	2008
Pharmacological intervention to the inflammatory response from decompression sickness in rats. Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:2 Topics: Animals; Cyclooxygenase Inhibitors; Decompression Sickness; Hydroxyurea; Indoles; Indomethacin; Inflammation; Isoproterenol; Lipoxygenase Inhibitors; Lysine; Male; Phenylcarbamates; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Sulfonamides; Tosyl Compounds	2008
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury. Toxicology, 1995, Jun-26, Volume: 100, Issue:1-3 Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Hydroxyurea; Indoles; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Phenyl Ethers; Rats; Rats, Sprague-Dawley	1995
Preclinical and clinical activity of zileuton and A-78773. Annals of the New York Academy of Sciences, 1993, Nov-30, Volume: 696 Topics: Animals; Bronchial Spasm; Guinea Pigs; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Rats	1993
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis and rheumatism, 1996, Volume: 39, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan	1996
The effect of 5-lipoxygenase inhibition on Ascaris antigen (Ag)-induced responses in atopic monkeys. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Helminth; Ascaris suum; Bronchoalveolar Lavage Fluid; Hydroxyurea; Inflammation; Leukocyte Count; Lipoxygenase Inhibitors; Macaca fascicularis; Male; Neutrophils; Pyrans; Quinolones	1996
Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. British journal of pharmacology, 1992, Volume: 107, Issue:4 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2	1992