zileuton has been researched along with Edema in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, X; Eckman, J; Hussoin, MS; Hwang, SB; Ip, SH; Killian, DB; Libertine-Garahan, L; Qian, C; Scannell, RT; Shen, TY; Yaeger, D; Yeh, CG | 1 |
| Brůnová, B; Jandera, A; Junek, R; Kuchar, M; Kverka, M; Panajotová, V | 1 |
| Abraham, WM; Albert, L; Behnke, ML; Chen, L; Clark, JD; Donahue, F; Foley, MA; Goodwin, DG; Hegen, M; Hu, B; Hu, Y; Ipek, M; Keith, J; Kirincich, SJ; Ku, MS; Lee, KL; McKew, JC; Michalak, R; Murphy, EA; Nickerson-Nutter, CL; Ramarao, MK; Shen, MW; Sum, FW; Tam, S; Thakker, P; Thomason, J; Williams, C; Wooder, L; Wu, K; Xu, X | 1 |
| Atanasov, AG; Bauer, J; Bauer, R; Baumgartner, L; Bodensieck, A; Dirsch, VM; Fakhrudin, N; Favero, GD; Heiss, EH; Ladurner, A; Loggia, RD; Ponti, C; Rollinger, JM; Schwaiger, S; Sosa, S; Stuppner, H; Tubaro, A; Werz, O; Widowitz, U | 1 |
| Cheon, HG; Cho, YS; Suh, J; Yum, EK | 1 |
| Jain, S; Özadalı, K; Özkanlı, F; Rao, PP; Velázquez-Martínez, CA | 1 |
| Banerjee, AG; Das, N; Shengule, SA; Shrivastava, SK; Srivastava, RS | 1 |
| Ambruosi, M; Belardo, C; Collarile, S; de Rosa, M; Dehm, F; Esposito, V; Filosa, R; Guida, F; Krauth, V; Maione, S; Massa, A; Peduto, A; Werz, O | 1 |
| D'Agostino, B; de Rosa, M; Esposito, V; Filosa, R; Krauth, V; Peduto, A; Rossi, A; Roviezzo, F; Schiraldi, C; Schuster, D; Scuotto, M; Stuppner, H; Temml, V; Werz, O | 1 |
| Bandresh, R; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN | 1 |
| Banoglu, E; Bruno, F; D'Amico, M; De Rosa, M; Errico, S; Filosa, R; Fiorentino, A; Guida, F; Maione, S; Maisto, R; Mkrtchyan, AS; Nawrozkij, MB; Olgaç, A; Pace, S; Werz, O | 1 |
| Abid, OU; Ahmad, A; Ahmad, S; Ayaz, M; Hussain, F; Jan, MS; Mahmood, F; Rashid, U; Sadiq, A; Ullah, F | 1 |
| Bhatti, R; Kaur, J; Kumari, P; Singh, P | 1 |
| Boschi, D; Cena, C; Coruzzi, G; Di Stilo, A; Fruttero, R; Gasco, A; Giorgis, M; Guaita, E; Morini, G; Talniya, NC | 1 |
| da Silva, NG; Gonçalves, LR; Sampaio, SC | 1 |
| Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Jiang, X; Karlsson, L; Lundeen, KA; Rao, NL; Riley, JP; Williams, KN; Xue, X | 1 |
| Askonas, LJ; Ghoreishi-Haack, N; Kachur, JF; Liang, CD; Russell, MA; Smith, WG; Villani-Price, D; Won-Kim, S | 1 |
| Albert, DH; Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Dyer, R; Summers, JB; Young, PR | 1 |
18 other study(ies) available for zileuton and Edema
| Article | Year |
|---|---|
(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.
Topics: Animals; Arachidonic Acid; Blood Platelets; Cell Membrane; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Edema; Enzyme Inhibitors; Furans; Hematocrit; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urea | 1998 |
Antileukotrienic N-arylethyl-2-arylacetamides in the treatment of ulcerative colitis.
Topics: Acetamides; Animals; Colitis, Ulcerative; Disease Models, Animal; Edema; Hydrophobic and Hydrophilic Interactions; Leukotriene B4; Neutrophils; Rats; Receptors, Leukotriene B4; Structure-Activity Relationship | 2007 |
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoates; Biological Availability; Bronchoconstriction; Calorimetry; Carrageenan; Cell Line; Cyclooxygenase 2 Inhibitors; Edema; Group IV Phospholipases A2; Humans; In Vitro Techniques; Isoenzymes; Male; Mice; Protein Binding; Rats; Rats, Sprague-Dawley; Sheep; Structure-Activity Relationship; Sulfonamides | 2008 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Austria; Benzofurans; Cyclooxygenase 1; Edema; Intramolecular Oxidoreductases; Krameriaceae; Lignans; Male; Mice; NF-kappa B; Plant Roots; Prostaglandin-E Synthases | 2011 |
Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors.
Topics: Administration, Oral; Amines; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Edema; Lipoxygenase Inhibitors; Mice; Rats; Structure-Activity Relationship; Thiazoles | 2012 |
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Binding Sites; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Enzyme Activation; Humans; Isoxazoles; Lipoxygenase Inhibitors; Protein Binding; Pyridazines; Rats | 2012 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Kinetics; Mice; Molecular Dynamics Simulation; Molecular Structure; Oxadiazoles; Pain; Rats; Stomach Ulcer; Structure-Activity Relationship; Triazines | 2015 |
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.
Topics: Adult; Animals; Arachidonate 5-Lipoxygenase; Carrageenan; Dose-Response Relationship, Drug; Edema; Humans; Indoles; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Structure; Neutrophils; Structure-Activity Relationship | 2016 |
Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Benzoquinones; Edema; Humans; Hydroquinones; Lipoxygenase Inhibitors; Male; Mice; Molecular Docking Simulation; Peritonitis; Protein Conformation; Structure-Activity Relationship | 2017 |
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Indolizines; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Ulcer | 2017 |
Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Dose-Response Relationship, Drug; Edema; Humans; Indoles; Inflammation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Molecular Structure; Neutrophils; Prostaglandin-E Synthases; Structure-Activity Relationship | 2018 |
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Design; Edema; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Pyrrolidines; Structure-Activity Relationship | 2020 |
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Tartrates | 2021 |
Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Drug Design; Edema; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Nitric Oxide; Rats; Structure-Activity Relationship | 2010 |
Inhibitory effect of Crotalus durissus terrificus venom on chronic edema induced by injection of bacillus Calmette-Guérin into the footpad of mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BCG Vaccine; Chronic Disease; Crotalid Venoms; Crotalus; Crotoxin; Dexamethasone; Edema; Foot; Hindlimb; Hydroxyurea; Inflammation; Injections, Subcutaneous; Lipoxygenase; Male; Mice; Mycobacterium bovis | 2013 |
Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Ascitic Fluid; Benzothiazoles; Dogs; Ear; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Female; Humans; Hydroxyurea; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxins; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neutrophil Infiltration; Peritonitis; Piperidines; Recombinant Proteins | 2007 |
Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies.
Topics: Administration, Oral; Administration, Topical; Animals; Arthus Reaction; beta-Alanine; Dermatitis; Edema; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Hydroxyurea; In Vitro Techniques; Leukotriene A4; Leukotriene Antagonists; Lipoxygenase Inhibitors; Mice; Peritoneum; Rats; Skin | 2002 |
5-lipoxygenase inhibitory activity of zileuton.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromatography, High Pressure Liquid; Dogs; Edema; Haplorhini; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Rats; Rats, Inbred Strains; Species Specificity | 1991 |