zileuton and Disease Models, Animal

Topics: Acetamides; Animals; Colitis, Ulcerative; Disease Models, Animal; Edema; Hydrophobic and Hydrophilic Interactions; Leukotriene B4; Neutrophils; Rats; Receptors, Leukotriene B4; Structure-Activity Relationship

Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; Kinetics; Mice; Molecular Dynamics Simulation; Molecular Structure; Oxadiazoles; Pain; Rats; Stomach Ulcer; Structure-Activity Relationship; Triazines

Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Humans; Hydroxyurea; Inhibitory Concentration 50; Intramolecular Oxidoreductases; Lipoxygenase Inhibitors; Mice; Molecular Structure; Prenylation; Prostaglandin-E Synthases; Rutaceae; Structure-Activity Relationship

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Indolizines; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Ulcer

Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Glutathione Transferase; Humans; Molecular Structure; Pyrazines; Rats; Structure-Activity Relationship

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Proliferation; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, SCID; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Disease Models, Animal; Ferroptosis; Gene Knockdown Techniques; Humans; Hydroxyurea; Iodates; Lipoxygenase Inhibitors; Macular Degeneration; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Retinal Pigment Epithelium; Signal Transduction; Transfection

Topics: Animals; COVID-19; Disease Models, Animal; Humans; Immunity, Innate; Lipoxygenase Inhibitors; Lung; Mice; Mice, Transgenic; SARS-CoV-2; Weight Loss

Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxyurea; Lipoxygenase Inhibitors; Male; Mice; Myocytes, Cardiac; NF-E2-Related Factor 2; PPAR alpha; Rats; Signal Transduction; Ventricular Remodeling

Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Disease Models, Animal; Humans; Hydroxyurea; Inflammation; Infusions, Intraventricular; Lipoxygenase Inhibitors; Male; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subarachnoid Hemorrhage

Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP; Depression; Depressive Disorder; Disease Models, Animal; Fluoxetine; Hippocampus; Hydroxyurea; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation

Topics: Animals; Cognition; Disease Models, Animal; Hydroxyurea; Leukotriene Antagonists; Mice; Mice, Transgenic; Phosphorylation; tau Proteins

Topics: Animals; Benzopyrans; Carboxylic Acids; Choroidal Neovascularization; Disease Models, Animal; Eye; Eye Injuries; Hydroxyurea; Indoles; Lasers; Leucine; Leukotriene B4; Macrophages; Macular Degeneration; Male; Mice; Mice, Knockout; Neovascularization, Pathologic; Receptors, Leukotriene B4; Signal Transduction

Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arachidonate 5-Lipoxygenase; Brain; Conditioning, Classical; Disease Models, Animal; Excitatory Postsynaptic Potentials; Fear; Gene Expression Regulation; Humans; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Memory Disorders; Mice; Mice, Transgenic; Mutation; Presenilin-1; Synapses; tau Proteins

Topics: Animals; Arachidonate 5-Lipoxygenase; Brain Ischemia; CA1 Region, Hippocampal; Disease Models, Animal; Hydroxyurea; Lipoxygenase Inhibitors; Male; Neurons; Rats; Rats, Sprague-Dawley

Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Line; Cell Line, Tumor; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Heparin-binding EGF-like Growth Factor; Heterografts; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukotriene B4; Macrophages; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Mice; Neoplasm Metastasis; Ovarian Neoplasms; Tumor Necrosis Factor-alpha

Topics: Analgesia; Analgesics; Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Hyperalgesia; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pain; Pain Threshold; Rats; Umbelliferones

Topics: Animals; Colonic Neoplasms; Disease Models, Animal; Female; Humans; Hydroxyurea; Inflammatory Bowel Diseases; Intestinal Polyposis; Lipoxygenase Inhibitors; Male; Mice; Mice, Mutant Strains

Topics: Animals; Arachidonate 5-Lipoxygenase; Brain; Cerebellum; Cerebral Cortex; Cyclin-Dependent Kinase 5; Disease Models, Animal; Encephalitis; Excitatory Postsynaptic Potentials; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phenotype; Phosphorylation; Synapses; tau Proteins; Tauopathies

Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Infarction; Carotid Stenosis; Cytokines; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme-Linked Immunosorbent Assay; Hydroxyurea; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nervous System Diseases

Topics: Anemia, Sickle Cell; Animals; Asthma; Disease Models, Animal; Hydroxyurea; Interleukin-13; Leukotrienes; Mice; Mice, Knockout; Placenta Growth Factor; Pregnancy Proteins; Th2 Cells

Topics: Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Hydroxyurea; Janus Kinase 2; Leukotriene Antagonists; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Polycythemia Vera; Polymerase Chain Reaction

Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Leukotriene Antagonists; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

Topics: Analysis of Variance; Animals; Benzoates; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Glycoproteins; Group IV Phospholipases A2; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Myelin-Oligodendrocyte Glycoprotein; Naproxen; Peptide Fragments; Severity of Illness Index; Seveso Accidental Release; Sulfonamides; Th1 Cells; Time Factors

Topics: Administration, Topical; Analysis of Variance; Animals; Anticarcinogenic Agents; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Combinations; Head and Neck Neoplasms; Hydroxyurea; Lipoxygenase Inhibitors; Mice; Mice, Nude; Pyrazoles; Random Allocation; Skin Neoplasms; Sulfonamides

Topics: Allergens; Anaphylaxis; Animals; Arachis; Cholera Toxin; Cimetidine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Hydroxyurea; Immunoglobulin E; Immunoglobulin G; Lipoxygenase Inhibitors; Mice; Mice, Inbred C57BL; Peanut Hypersensitivity; Platelet Membrane Glycoproteins; Pyrilamine; Receptors, G-Protein-Coupled; Receptors, Histamine

Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Humans; Hydroxyurea; Imidazoles; Immunohistochemistry; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Male; Osteoarthritis; Pain; Rats; Rats, Sprague-Dawley; Substrate Specificity; Sulfides

Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Hydroxyurea; Immunohistochemistry; Interleukin-1beta; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Malondialdehyde; Neuroprotective Agents; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Time Factors; Transcription Factor RelA; Tumor Necrosis Factor-alpha

Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Humans; Hydroxyurea; Interferon-gamma; Intramolecular Oxidoreductases; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Mice; Mice, Inbred Strains; Pleurisy; Prostaglandin-E Synthases; Prostaglandins F; Rats; Rats, Wistar; Zymosan

Topics: Allergens; Ambrosia; Animals; Conjunctivitis, Allergic; Disease Models, Animal; Glucocorticoids; Histamine; Histamine H1 Antagonists, Non-Sedating; Hydroxyurea; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Injections, Intraocular; Injections, Subcutaneous; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mast Cells; Mice; Mice, Inbred ICR; Phenylpropionates; Pollen; Terfenadine

Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Hydroxyurea; Inflammation; Leukotriene Antagonists; Leukotrienes; Lung; Mice; Mice, Inbred BALB C; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Time Factors; Virus Replication; Weight Loss

Topics: Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Ischemia; Kidney Diseases; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Mice, Knockout; Neutrophils; Peroxidase; Reperfusion Injury

Topics: Animals; Arachidonate 5-Lipoxygenase; CD11 Antigens; CD18 Antigens; Chemotaxis, Leukocyte; Disease Models, Animal; Endotoxemia; Enzymes; Gene Targeting; Hydroxyurea; Leukocytes; Lipopolysaccharides; Lipoxygenase Inhibitors; Liver; Lung; Male; Mice; Mice, Knockout; Multiple Organ Failure; Pancreas; Rats; Rats, Wistar; Viscera

Topics: Adenocarcinoma; Anastomosis, Surgical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Body Weight; Celecoxib; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esophageal Neoplasms; Humans; Hydroxyurea; Immunohistochemistry; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors

Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; Carcinoma, Squamous Cell; Celecoxib; Cell Transformation, Neoplastic; Chemoprevention; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Hydroxyurea; Immunohistochemistry; In Situ Hybridization; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mesocricetus; Mouth Neoplasms; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Up-Regulation

Topics: Adenoma; Administration, Inhalation; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydroxamic Acids; Hydroxyurea; Incidence; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred Strains; Phenylurea Compounds

Topics: Acetates; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclopropanes; Cysteine; Dinoprostone; Disease Models, Animal; Gene Expression Regulation; Hydroxyurea; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Male; Mice; Neutrophil Infiltration; Quinolines; Recovery of Function; Spinal Cord Injuries; Sulfides; Tumor Necrosis Factor-alpha

Topics: Air; Animals; Arachidonate 5-Lipoxygenase; Biological Assay; Calcimycin; Carrageenan; Cell Line, Tumor; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyurea; Imidazoles; Immunoglobulin E; Inflammation; Ionophores; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Oxidation-Reduction; Rats; Rats, Inbred Lew; Reproducibility of Results; Sulfides; Tandem Mass Spectrometry

Topics: 1-Naphthylisothiocyanate; Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Hydroxyurea; Indoles; Inflammation; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Liver; Liver Diseases; Male; Phenyl Ethers; Rats; Rats, Sprague-Dawley

Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Hydroxyurea; Indazoles; Lipoxygenase Inhibitors; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Pyrilamine; SRS-A; Trachea

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan

Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxyurea; Leukotriene Antagonists; Random Allocation; Sheep

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hydroxyurea; Inflammation; Knee Joint; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Oxidation-Reduction; Pyrans; Quinolones; Rabbits; Rats; Thromboxane B2

Topics: Administration, Oral; Anaphylaxis; Animals; Disease Models, Animal; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Peritoneal Cavity; Rats; Rats, Inbred Strains; SRS-A