zileuton has been researched along with Asthma in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 42 (52.50) | 18.2507 |
| 2000's | 30 (37.50) | 29.6817 |
| 2010's | 7 (8.75) | 24.3611 |
| 2020's | 1 (1.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kreft, AF; Musser, JH | 1 |
| Augert, G; Cottin, M; Demonchaux, P; Dupassieux, P; Jasserand, D; Lenoir, P; Paris, D; Peck, MJ | 1 |
| Andersson, U; Andreasson, T; Bergström, EL; Björkstrand, E; Bonn, B; Chang, HF; Chapman, D; Davis, AM; Ek, M; Glader, P; Gordon, E; Jiang, F; Johannesson, P; Käck, H; Lundqvist, AJ; Malmberg, A; Munck Af Rosenschöld, M; Nikitidis, A; Nikitidis, G; Pettersen, A; Ripa, L; Rohman, M; Rönn, R; Swedin, L; Tyrchan, C; Ullah, V; Wågberg, F; Zhou, XH | 1 |
| Holguin, F; Nouraie, M; Parikh, A; Thalanayar Muthukrishnan, P | 1 |
| Dahlin, A; Irvin, CG; Kubo, M; Lima, JJ; Litonjua, AA; Peters, SP; Qiu, W; Tamari, M; Tantisira, KG; Weiss, ST; Wu, AC | 1 |
| Seow, CY; van Eeden, S | 1 |
| Chang, FT; Chen, WJ; Liaw, SF; Lin, CC; Lin, MW | 1 |
| Dahlin, A; Irvin, CG; Kubo, M; Lima, JJ; Litonjua, A; Peters, SP; Tamari, M; Tantisira, KG | 1 |
| Arumugam, PI; Brandt, EB; Carmeliet, P; Eiymo Mwa Mpollo, MS; Hershey, GK; Jonck, B; Kalra, VK; Le Cras, TD; Lindsey, M; Loberg, A; Malik, P; Pillis, D; Ratner, N; Rizvi, T; Shanmukhappa, SK; Tiwari, S; Wills-Karp, M | 1 |
| Klanderman, B; Lima, J; Sylvia, J; Tantisira, KG; Weiss, ST | 1 |
| Gelb, AF; Shinar, C; Simmons, M; Taylor, CF | 1 |
| Kroegel, C | 1 |
| Valacer, DJ | 1 |
| Dev, A; Leong, AB; Wu, X | 1 |
| Jung, A | 1 |
| Kemp, JP | 1 |
| Blanc, PD; Eisner, MD; Katz, PP; Snyder, L; Yelin, EH | 1 |
| Gershwin, ME; Morrissey, BM; Naguwa, S; Vang, K; Watnik, M; Wineinger, J; Ziboh, VA | 1 |
| Leru, P | 1 |
| Dahlén, SE | 1 |
| Capra, V; Cole, DE; Folco, G; Rovati, GE; Sala, A; Thompson, MD | 1 |
| Ludington, E; Mehra, P; Simon, RA; Stevenson, DD; White, A | 1 |
| Dickerson, KS; Luttermoser, GK; Scow, DT | 1 |
| Balter, M; Boulet, LP; Cairns, CB; Löfdahl, CG; O'Connor, BJ; Szczeklik, A | 1 |
| Berger, W; Cairns, CB; De Chandt, MT | 1 |
| Busse, W; Calhoun, W; Dube, L; Harris, J; Panettieri, R; Peters-Golden, M; Russell, H; Walton-Bowen, K; Wenzel, S | 1 |
| Berger, W; Casale, T; Corren, J; Dube, L; Kemp, J; LaVallee, N; Nelson, H; Stepanians, M; Walton-Bowen, K | 1 |
| Cameron, CM; Dube, LM; Kasten, LE; Walton-Bowen, K; Watkins, PB | 1 |
| Awni, WM; Cohn, J; Drazen, JM; Fischer, AR; Frantz, R; Israel, E; McFadden, CA | 1 |
| Ado, VA; Mokronosova, MA; Perlamutrov, IuN | 1 |
| Cohn, J; Kaminsky, DA; Martin, RJ; Trudeau, JB; Wenzel, SE; Westcott, JY | 1 |
| Ford-Hutchinson, AW | 1 |
| Callery, JC; Cohn, J; Drazen, JM; Fischer, AR; Igarashi, Y; Kaliner, MA; Lilly, CM; Rosenberg, MA; Rubin, P; White, MV | 1 |
| Busse, W; Cohn, J; Drazen, JM; Fish, J; Grossman, J; Israel, E; Kaiser, HB; Karahalios, P; Kemp, JP; Lanni, C; Ledford, D; Murray, JJ; Pearlman, H; Pierson, W; Rosenthal, R; Rubin, P; Segal, AT; Siegel, SC; Tinkelman, D; Wenzel, S | 1 |
| Callery, JC; Cohn, J; Drazen, JM; Fischer, AR; Israel, E; Lilly, CM; Rosenberg, MA; Rubin, P; Shapiro, J | 1 |
| Berkenkopf, JW; Carlson, RP; Grimes, D; Kreft, AF; Marinari, LR; Musser, JH; Sturm, RJ; Weichman, BM | 1 |
| Cohn, J; Drazen, JM; Dubé, L; Israel, E | 1 |
| Busse, WW; McGill, KA | 1 |
| Smith, LJ | 1 |
| Dubé, LM; Lancaster, J; Liu, MC | 1 |
| Tanaka, R | 1 |
| Jackson, SK; Larsen, JS | 1 |
| Spector, SL; Tan, RA | 1 |
| Dubé, LM; Lancaster, JF; Petty, T; Schwartz, HJ; Swanson, LJ | 1 |
| Drazen, JM | 1 |
| Bootsma, GP; Dekhuijzen, PN; Festen, J; van den Berg, LR; van Herwaarden, CL; Wielders, PL | 1 |
| Tan, RA | 1 |
| Wenzel, SE | 1 |
| Bochenek, G; Boodhoo, TI; Dahlén, B; Dahlén, SE; Dubé, LM; Kumlin, M; Mastalerz, L; Nizankowska, E; Pinis, G; Swanson, LJ; Szczeklik, A; Wright, S; Zetterström, O | 1 |
| Busse, WW; Horwitz, RJ; McGill, KA | 1 |
| Barberà, JA; Chung, KF; Gómez, FP; Iglesia, R; Roca, J; Rodriguez-Roisin, R | 1 |
| Drazen, J | 1 |
| Callens, E; Djebbar, R; Ruff, F; Santais, MC | 1 |
| Bouboulis, D; Frieri, M; Lark, G; Sansone, G; Schaefer, PA; Therattil, JM; Wang, SF; Zitt, M | 1 |
| Lane, SJ | 1 |
| Abraham, WM; Allegra, L; Scuri, M | 1 |
| Dubé, LM; DuBuske, LM; Grossman, J; Lancaster, JF; Swanson, LJ | 1 |
| Carpentier, PJ; Dubé, LM; Kemp, JP; Lancaster, JF; Lazarus, SC; Lee, T; Ochs, RF; Wenzel, S | 1 |
| Kuna, P; Kupczyk, M | 1 |
| Bleecker, ER; Dubé, LM; Hasday, JD; Hebel, JR; Lanni, C; Meltzer, SS; Moore, WC; Wisniewski, P | 1 |
| Dellaripa, PF; Drazen, J; Roth, ME; Wechsler, ME | 1 |
| Lang, DM | 1 |
| Daffern, PJ; Pauls, JD; Simon, RA; Stevenson, DD | 1 |
| Bisgaard, H | 1 |
| Drazen, JM; Dubé, L; Israel, E; Juniper, EF; Moy, ML; Weiss, ST | 1 |
| Krawiec, ME; Wenzel, SE | 1 |
| García-Marcos, L; Schuster, A | 1 |
| Spector, SL | 1 |
| Adachi, M; Minoguchi, K | 1 |
| Hayden, ML | 1 |
| Abraham, WM; Ahmed, A; Bell, RL; Bouska, J; Cortes, A; Hinz, W; Lanni, C; Sielczak, MW | 1 |
| O'Donnell, M; Payne, AN | 1 |
| Barnes, NC; Barnes, PJ; Hui, KP; Kesterson, J; Rubin, P; Taylor, GW; Taylor, IK | 1 |
| Bukantz, SC | 1 |
| Raub, W | 1 |
| Dermarkarian, R; Drazen, JM; Israel, E; Rosenberg, M; Rubin, P; Sperling, R; Taylor, G | 1 |
30 review(s) available for zileuton and Asthma
| Article | Year |
|---|---|
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.
Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Eosinophils; Humans; Inflammation; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lung Diseases; Neutrophils; Quinolines | 1992 |
[What helps for persistent symptoms of asthma during inhalative steroid therapy?].
Topics: Acetates; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Child; Cyclopropanes; Drug Therapy, Combination; Ethanolamines; Formoterol Fumarate; Humans; Hydroxyurea; Leukotriene Antagonists; Quality of Life; Quinolines; Randomized Controlled Trials as Topic; Respiratory Function Tests; Salmeterol Xinafoate; Sulfides; Treatment Failure | 2011 |
New treatments for asthma: the role of leukotriene modifier agents.
Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Asthma, Exercise-Induced; Cyclopropanes; Drug Evaluation; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome | 1999 |
[Anti-leukotrienes in allergic diseases in children].
Topics: Acetates; Asthma; Child; Cyclopropanes; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Quinolines; Receptors, Leukotriene; Sulfides | 2003 |
Recent advances in the management of asthma using leukotriene modifiers.
Topics: Acetates; Administration, Inhalation; Adolescent; Adult; Asthma; Child; Child, Preschool; Chromones; Controlled Clinical Trials as Topic; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxyurea; Leukotriene Antagonists; Male; Middle Aged; Peak Expiratory Flow Rate; Quinolines; Respiratory Function Tests; Severity of Illness Index; Sulfides; Treatment Outcome | 2003 |
Leukotrienes antagonists in the management of bronchial asthma.
Topics: Asthma; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotrienes | 2003 |
Treatment of asthma with antileukotrienes: first line or last resort therapy?
Topics: Acetates; Animals; Asthma; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Lipoxygenase Inhibitors; Membrane Proteins; Quinolines; Receptors, Leukotriene; Respiratory System; Rhinitis; Sulfides | 2006 |
Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends.
Topics: Adult; Animals; Asthma; Cardiovascular Diseases; Child; Child, Preschool; Dermatitis, Atopic; Female; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Membrane Proteins; Pharmacogenetics; Receptors, Leukotriene; Receptors, Purinergic; Recombinant Proteins; Rhinitis, Allergic, Seasonal; SRS-A; Tissue Distribution | 2007 |
Leukotriene inhibitors in the treatment of allergy and asthma.
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Asthma, Exercise-Induced; Cyclopropanes; Dermatitis, Atopic; Humans; Hydroxyurea; Hypersensitivity; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sulfides; Sulfonamides; Tosyl Compounds | 2007 |
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Dermatitis, Atopic; Drug Administration Schedule; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Pulmonary Disease, Chronic Obstructive; Rhinitis | 2007 |
[Allergy and leukotrienes].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Dermatitis, Atopic; Humans; Hydroxyurea; Hypersensitivity; Leukotrienes; Lipoxygenase Inhibitors; Receptors, Leukotriene | 1995 |
Leukotriene antagonists and inhibitors: clinical applications.
Topics: Animals; Asthma; Glomerulonephritis; Humans; Hydroxyurea; Indoles; Inflammatory Bowel Diseases; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Propionates; Psoriasis; Quinolines; Receptors, Leukotriene | 1995 |
Zileuton.
Topics: Arthritis, Rheumatoid; Asthma; Humans; Hydroxyurea; Lipoxygenase Inhibitors | 1996 |
Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Hydroxyurea; Indoles; Inflammation; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds | 1996 |
[5-lipoxygenase inhibitors in asthma therapy].
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acids; Asthma; Humans; Hydroxyurea; Lipoxygenase Inhibitors | 1996 |
Antileukotriene therapy for asthma.
Topics: Asthma; Humans; Hydroxyurea; Inflammation; Leukotrienes; Lipoxygenase Inhibitors | 1996 |
Antileukotriene agents.
Topics: Anti-Asthmatic Agents; Asthma; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds | 1997 |
New directions in asthma drug therapy.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chromones; Humans; Hydroxyurea; Indoles; Inflammation; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds | 1998 |
The role of antileukotrienes in asthma management.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Chromones; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds | 1998 |
New approaches to anti-inflammatory therapy for asthma.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Dicarboxylic Acids; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Steroids; Sulfonamides; Tosyl Compounds | 1998 |
The role of leukotriene modifiers in the treatment of asthma.
Topics: Animals; Asthma; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Sulfonamides; Tosyl Compounds | 1998 |
Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Phenylcarbamates; Randomized Controlled Trials as Topic; Sulfonamides; Tosyl Compounds; Treatment Outcome | 1998 |
[Potential importance of antileukotrienes in the treatment of asthma and other inflammatory diseases: apropos of a new pharmacological class].
Topics: Acetophenones; Adult; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Asthma; Bronchoconstriction; Child; Clinical Trials as Topic; Crohn Disease; Cystic Fibrosis; Haplorhini; Humans; Hydroxyurea; Indazoles; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Psoriasis; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sulfonamides; Tetrazoles; Tosyl Compounds | 1998 |
Leukotriene antagonism in asthma and rhinitis.
Topics: Acetates; Asthma; Bronchi; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Membrane Proteins; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Rhinitis; Sinusitis; Sulfides; Sulfonamides; Tosyl Compounds | 1998 |
[The role of leukotrienes in inflammation and leukotriene inhibitors].
Topics: Acetates; Arachidonate 5-Lipoxygenase; Asthma; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds | 1999 |
Leukotriene modifiers in pediatric asthma management.
Topics: Acetates; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Child; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Membrane Proteins; Phenylcarbamates; Quinolines; Receptors, Leukotriene; Sulfides; Sulfonamides; Tosyl Compounds | 2001 |
Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma.
Topics: Acetates; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Asthma; Bronchoconstriction; Child; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Phosphodiesterase Inhibitors; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome | 2001 |
Antileukotrienes in asthma: present situation.
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Chromones; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds | 2001 |
[Leukotriene modifiers].
Topics: Acetates; Asthma; Chromones; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Phenylcarbamates; Practice Guidelines as Topic; Quinolines; Receptors, Leukotriene; Sulfides; Sulfonamides; Tosyl Compounds | 2001 |
Leukotriene modifiers. Expanded role may be on horizon.
Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Cyclopropanes; Drug Interactions; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Patient Compliance; Phenylcarbamates; Quinolines; Safety; Steroids; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome | 2000 |
25 trial(s) available for zileuton and Asthma
| Article | Year |
|---|---|
Genome-wide association study of leukotriene modifier response in asthma.
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Cohort Studies; Cyclopropanes; Gene-Environment Interaction; Genetic Loci; Genome-Wide Association Study; Genotype; Humans; Hydroxyurea; Leukotrienes; Phenotype; Polymorphism, Single Nucleotide; Quinolines; Sulfides | 2016 |
5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Cysteine; Female; Forced Expiratory Volume; Genotype; Humans; Hydroxyurea; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Polymorphism, Single Nucleotide; Quinolines; Receptors, Leukotriene; Sulfides | 2009 |
Role of add-on zileuton on total exhaled, large airway, and small airway/alveolar nitric oxide in moderate-severe persistent adult asthmatics on fluticasone 250 microg/Salmeterol 50 microg.
Topics: Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Drug Therapy, Combination; Eosinophils; Female; Fluticasone; Humans; Hydroxyurea; Juniperus; Leukocyte Count; Male; Middle Aged; Nitric Oxide; Prospective Studies; Pulmonary Alveoli; Respiratory Function Tests; Respiratory System; Salmeterol Xinafoate; Spirometry | 2009 |
Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma.
Topics: Adult; Aged; Arthritis, Rheumatoid; Asthma; Dietary Supplements; Double-Blind Method; Fatty Acids; Female; gamma-Linolenic Acid; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Neutrophils; Plant Oils; Prospective Studies | 2004 |
Effect of leukotriene modifier drugs on the safety of oral aspirin challenges.
Topics: Acetates; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Asthmatic Agents; Aspirin; Asthma; Cyclopropanes; Desensitization, Immunologic; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds; Treatment Outcome | 2006 |
Zileuton added to low-dose inhaled beclomethasone for the treatment of moderate to severe persistent asthma.
Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Beclomethasone; Double-Blind Method; Drug Therapy, Combination; Forced Expiratory Volume; Glucocorticoids; Humans; Hydroxyurea; Middle Aged; Peak Expiratory Flow Rate; Severity of Illness Index; Single-Blind Method | 2007 |
The safety and efficacy of zileuton controlled-release tablets as adjunctive therapy to usual care in the treatment of moderate persistent asthma: a 6-month randomized controlled study.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Asthma; Child; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Peak Expiratory Flow Rate; Quality of Life; Tablets | 2007 |
Efficacy of zileuton controlled-release tablets administered twice daily in the treatment of moderate persistent asthma: a 3-month randomized controlled study.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Hydroxyurea; Inhalation; Middle Aged; Tablets; Treatment Outcome | 2007 |
Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Asthma; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Liver Function Tests; Male; Prospective Studies | 2007 |
Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.
Topics: Adult; Arachidonate 5-Lipoxygenase; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cold Temperature; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Single-Blind Method; Time Factors | 1995 |
Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Inflammation; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Middle Aged | 1995 |
Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma.
Topics: Adult; Aspirin; Asthma; Blood Proteins; Chymases; Cross-Over Studies; Double-Blind Method; Eosinophil Granule Proteins; Female; Histamine; Humans; Hydroxyurea; Leukotrienes; Male; Mast Cells; Middle Aged; Nasal Mucosa; Ribonucleases; Serine Endopeptidases; Tryptases | 1994 |
The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma.
Topics: Adult; Albuterol; Asthma; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene E4; Lipoxygenase Inhibitors; Male; Single-Blind Method | 1993 |
The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin.
Topics: Adult; Arachidonate 5-Lipoxygenase; Aspirin; Asthma; Bronchoconstriction; Double-Blind Method; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene E4; Lipoxygenase Inhibitors; Male; Middle Aged | 1993 |
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
Topics: Adrenergic beta-Agonists; Adult; Analysis of Variance; Asthma; Double-Blind Method; Drug Administration Schedule; Drug Monitoring; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Liver; Liver Function Tests; Male; Peak Expiratory Flow Rate; Quality of Life | 1996 |
Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Bronchoconstriction; Double-Blind Method; Drug Therapy, Combination; Eosinophils; Female; Forced Expiratory Volume; Histamine Antagonists; Humans; Hydroxyurea; Leukocyte Count; Leukotrienes; Lipoxygenase Inhibitors; Liver Function Tests; Male; Middle Aged; Time Factors; Treatment Outcome | 1996 |
A randomized controlled trial comparing zileuton with theophylline in moderate asthma. The Zileuton Study Group.
Topics: Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lung Volume Measurements; Male; Middle Aged; Severity of Illness Index; Theophylline; Time Factors; Treatment Outcome | 1998 |
Effects of single-dose zileuton on bronchial hyperresponsiveness in asthmatic patients treated with inhaled corticosteroids.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Histamine; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Reference Values; Respiratory Function Tests; Sensitivity and Specificity; Water | 1997 |
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Glucocorticoids; Histamine; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotriene D4; Lipoxygenase Inhibitors; Male; Middle Aged; Peak Expiratory Flow Rate | 1998 |
The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma.
Topics: Adult; Airway Resistance; Asthma; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Neutropenia; Oxygen; Platelet Activating Factor; Pulmonary Gas Exchange; Respiratory Mechanics; Ventilation-Perfusion Ratio | 1998 |
Randomized trial of zileuton in patients with moderate asthma: effect of reduced dosing frequency and amounts on pulmonary function and asthma symptoms. Zileuton Study Group.
Topics: Adolescent; Adult; Aged; Asthma; Double-Blind Method; Drug Administration Schedule; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Managed Care Programs; Middle Aged; Respiratory Function Tests; Respiratory System Agents; United States | 1997 |
Safety and clinical efficacy of zileuton in patients with chronic asthma.
Topics: Asthma; Chronic Disease; Disease Management; Forced Expiratory Volume; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Managed Care Programs; Safety; Treatment Outcome; United States | 1998 |
Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxyurea; Inflammation Mediators; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Male; Skin Tests | 2000 |
Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients.
Topics: Adult; Allergens; Asthma; Double-Blind Method; Forced Expiratory Volume; Humans; Hydroxyurea; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; SRS-A; Time Factors | 1991 |
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Calcimycin; Cold Temperature; Double-Blind Method; Eicosanoids; Humans; Humidity; Hydroxyurea; Lipoxygenase Inhibitors; Male | 1990 |
25 other study(ies) available for zileuton and Asthma
| Article | Year |
|---|---|
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application i
Topics: Animals; Asthma; Female; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolines; Rabbits; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Skin Tests; Structure-Activity Relationship | 1995 |
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1
Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Glutathione Transferase; Humans; Molecular Structure; Pyrazines; Rats; Structure-Activity Relationship | 2019 |
Zileuton use and phenotypic features in asthma.
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Lung; Male; Middle Aged; Phenotype; Respiratory Function Tests; Retrospective Studies; Severity of Illness Index | 2020 |
The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma.
Topics: Asthma; Cell Line; Humans; Hydroxyurea; Leukotrienes; Phosphatidylinositol 3-Kinases; Polymorphism, Single Nucleotide; Quantitative Trait Loci; RNA, Messenger; Signal Transduction | 2018 |
Airway remodeling in asthma: tumor of the airway?
Topics: Airway Remodeling; Allergens; Animals; Asthma; Hydroxyurea; Leukotriene Antagonists; Lung; Male | 2013 |
Effects of zileuton on airway smooth muscle remodeling after repeated allergen challenge in brown Norway rats.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Drug Evaluation, Preclinical; Hydroxyurea; Leukotriene Antagonists; Lung; Male; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Rats; Respiratory Function Tests; T-Lymphocytes | 2013 |
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13.
Topics: Anemia, Sickle Cell; Animals; Asthma; Disease Models, Animal; Hydroxyurea; Interleukin-13; Leukotrienes; Mice; Mice, Knockout; Placenta Growth Factor; Pregnancy Proteins; Th2 Cells | 2016 |
Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.
Topics: Adult; Aged; Asthma; Female; Humans; Hydroxyurea; Lipoxygenase Inhibitors; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 2003 |
Leukotriene modifier use and asthma severity: how is a new medication being used by adults with asthma?
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Female; Health Status Indicators; Hospitalization; Humans; Hydroxyurea; Leukotriene Antagonists; Logistic Models; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Quinolines; Sulfides | 2004 |
WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: biochemical characterization and antiallergic activity.
Topics: Administration, Oral; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asthma; Female; Guinea Pigs; Humans; Hydroxyurea; Indoles; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Mice; Naphthaleneacetic Acids; Prostaglandin-Endoperoxide Synthases; Quinolines; Rabbits; Rats; Rats, Wistar | 1993 |
Zileuton for asthma.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Hydroxyurea; Intestinal Absorption; Leukotrienes; Lipoxygenase Inhibitors; Propranolol; Theophylline; Warfarin | 1997 |
Allergen-stimulated leukotriene B4 and interleukin-8 levels in patients with asthma and allergic rhinitis-modulation by a lipid pathway inhibitor.
Topics: Adult; Aged; Allergens; Asthma; Female; Humans; Hydroxyurea; Interleukin-8; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1998 |
Drugs for asthma.
Topics: Acetates; Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bone Density; Bronchial Spasm; Bronchodilator Agents; Child; Child, Preschool; Choice Behavior; Cromolyn Sodium; Cyclopropanes; Exercise; Female; Growth; Humans; Hydroxyurea; Indoles; Infant, Newborn; Ipratropium; Lactation; Leukotriene Antagonists; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Tachycardia; Theophylline; Tosyl Compounds | 1999 |
The effects of multiple dosing with zileuton on antigen-induced responses in sheep.
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxyurea; Leukotriene Antagonists; Random Allocation; Sheep | 1998 |
Drugs for asthma.
Topics: Acetates; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Spasm; Child; Cromolyn Sodium; Cyclopropanes; Exercise; Female; Growth Disorders; Humans; Hydroxyurea; Indoles; Ipratropium; Lactation; Leukotriene Antagonists; Nebulizers and Vaporizers; Nedocromil; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Theophylline; Tosyl Compounds | 2000 |
The use of newer asthma and allergy medications during pregnancy. The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI).
Topics: Abnormalities, Drug-Induced; Acetates; Administration, Inhalation; Administration, Intranasal; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Budesonide; Chlorpheniramine; Cyclopropanes; Ephedrine; Female; Histamine H1 Antagonists; Humans; Hydroxyurea; Hypersensitivity; Indoles; Ipratropium; Leukotriene Antagonists; Metaproterenol; Nasal Decongestants; Nebulizers and Vaporizers; Nedocromil; Phenylcarbamates; Pregnancy; Pregnancy Complications; Quinolines; Salmeterol Xinafoate; Sulfides; Sulfonamides; Terbutaline; Tosyl Compounds; Tripelennamine | 2000 |
Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.
Topics: Acetates; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclopropanes; Diagnosis, Differential; Erythema Induratum; Humans; Hydroxyurea; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Middle Aged; Panniculitis, Nodular Nonsuppurative; Quinolines; Sulfides | 2000 |
Antileukotriene agents and aspirin-sensitive asthma: are we removing the second bassoonist or skating to where the puck is gonna be?
Topics: Aspirin; Asthma; Bronchial Spasm; Humans; Hydroxyurea; Leukotriene Antagonists; Therapeutic Equivalency | 2000 |
Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics.
Topics: Administration, Oral; Aspirin; Asthma; Desensitization, Immunologic; Humans; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors | 2000 |
Clinical predictors of health-related quality of life depend on asthma severity.
Topics: Adult; Albuterol; Analysis of Variance; Asthma; Female; Follow-Up Studies; Humans; Hydroxyurea; Male; Predictive Value of Tests; Probability; Quality of Life; Respiratory Function Tests; Retrospective Studies; Severity of Illness Index; Sickness Impact Profile; Treatment Outcome | 2001 |
Safety of antileukotriene agents in asthma management.
Topics: Acetates; Asthma; Churg-Strauss Syndrome; Clinical Trials as Topic; Cyclopropanes; Humans; Hydroxyurea; Indoles; Leukotriene Antagonists; Phenylcarbamates; Quinolines; Sulfides; Sulfonamides; Tosyl Compounds | 2001 |
The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.
Topics: Administration, Oral; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Dose-Response Relationship, Drug; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Sheep | 1992 |
Therapeutic approaches to reduce airway inflammation.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Blood Platelets; Bronchi; Cell Adhesion Molecules; Humans; Hydroxyurea; Intercellular Adhesion Molecule-1; Interleukin-5; Lipoxygenase Inhibitors | 1991 |
Asthma: the molecular light at the end of the tracheal tunnel.
Topics: Asthma; Humans; Hydroxyeicosatetraenoic Acids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Propionates; Quinolines | 1991 |
From the National Institutes of Health.
Topics: Arthritis, Juvenile; Asthma; CD4 Antigens; Cells, Cultured; Exotoxins; HIV-1; HLA Antigens; Humans; Hydroxyurea; Immunotoxins; Lipoxygenase Inhibitors; National Institutes of Health (U.S.); Recombinant Proteins; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; T-Lymphocytes; United States | 1991 |