zileuton has been researched along with Alzheimer Disease in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Andrés, L; Estrada Valencia, M; Herrera-Arozamena, C; Laurini, E; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Pricl, S; Ramos, E; Rodríguez-Franco, MI; Romero, A; Viña, D; Yáñez, M | 1 |
| Abu-Serie, MM; AlFadly, ED; Bakkar, NZ; Bartolini, M; Belal, ASF; El-Yazbi, AF; Elkazaz, S; Elzahhar, PA; Ghareeb, DA; Iriepa, I; Janockova, J; Kobeissy, F; Moraleda, I; Rafeh, RW; Saudi, MNS; Shaltout, H; Soukup, O; Tramarin, A | 1 |
| Barrero, C; Li, JG; Merali, S; Praticò, D | 1 |
| Chu, J; Giannopoulos, PF; Joshi, YB; Kirby, LG; Li, JG; Praticò, D; Sperow, M | 1 |
| Chu, J; Li, JG; Praticò, D | 1 |
| Di Meco, A; Lauretti, E; Praticò, D; Vagnozzi, AN | 1 |
| Chu, J; Praticò, D | 1 |
7 other study(ies) available for zileuton and Alzheimer Disease
| Article | Year |
|---|---|
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Donepezil; Enzyme Inhibitors; Flavonoids; Humans; Indans; Lipoxygenase Inhibitors; Male; Mice, Inbred BALB C; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurogenesis; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor | 2018 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 Inhibitors; Drug Design; Humans; Inflammation; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Neurons; PC12 Cells; Rats; Semicarbazides; Triazoles | 2019 |
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Diet; DNA Methylation; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hydroxyurea; Inflammation; Lipoxygenase; Male; Mice, Transgenic; Phenotype; Phosphorylation; Synapses; tau Proteins; Up-Regulation; Vitamin B Complex; Vitamin B Deficiency | 2017 |
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arachidonate 5-Lipoxygenase; Brain; Conditioning, Classical; Disease Models, Animal; Excitatory Postsynaptic Potentials; Fear; Gene Expression Regulation; Humans; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Memory Disorders; Mice; Mice, Transgenic; Mutation; Presenilin-1; Synapses; tau Proteins | 2014 |
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Arachidonate 5-Lipoxygenase; Cognition; Cyclin-Dependent Kinase 5; Female; Humans; Hydroxyurea; Immunoblotting; Immunohistochemistry; Lipoxygenase Inhibitors; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Synapses; tau Proteins | 2013 |
Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Amyloidogenic Proteins; Animals; Arachidonate 5-Lipoxygenase; Cyclin-Dependent Kinase 5; Hydroxyurea; Lipoxygenase Inhibitors; Memory; Mice, Transgenic; Molecular Targeted Therapy; Phosphorylation; Protein Aggregates; Protein Aggregation, Pathological; tau Proteins; Up-Regulation | 2014 |
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Female; Fibroblasts; Humans; Hydroxyurea; Immunohistochemistry; Lipoxygenase Inhibitors; Mice; Mice, Transgenic; Models, Biological; Mutation; Phenotype; Receptors, Notch | 2011 |