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zidovudine triphosphate and HIV

zidovudine triphosphate has been researched along with HIV in 19 studies

*HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. [MeSH]

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19905 (26.32)18.7374
1990's9 (47.37)18.2507
2000's3 (15.79)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
August, EM; Brankovan, V; Ghazzouli, I; Hitchcock, MJ; Lin, TS; Mansuri, MM; Prusoff, WH; Sommadossi, JP; Starrett, JE; Sterzycki, RZ1
Ilina, T; Myshakina, NS; Parniak, MA; Sirivolu, VR; Vernekar, SK; Wang, Z1
Elgaher, WA; Hartmann, RW; Haupenthal, J; Mély, Y; Pires, M; Real, E; Saladini, F; Sharma, KK1
Baba, M; Cheng, YC; Dutschman, GE; Grill, SP; Hu, R; Lam, W; Paintsil, E; Tanaka, H1
Clayton, DA; Eriksson, S; Xu, B1
Hall, ET; Kuchta, RD; Melançon, P; Yan, JP1
Jagannadh, B; Kunwar, AC; Reddy, DV1
Anderson, PL; Brundage, RC; Bushman, LR; Fletcher, CV; Kakuda, TN; Kawle, SP; Remmel, RP; Weller, D1
Back, DJ; Barry, MG; Dann, L; Gibbons, SE; Hoggard, PG; Khoo, SH; Lloyd, J; Loveday, C; Wilkins, EG1
Reardon, JE1
Chen, MS; Copeland, WC; Wang, TS1
Abbotts, J; Kedar, PS; Kovács, T; Lesiak, K; Torrence, P; Wilson, SH1
Farquhar, D; Huang, P; Plunkett, W1
Quan, K; Tao, P; Zhang, X1
Izuta, S; Kojima, K; Sakurai, T; Saneyoshi, M; Suzuki, M; Yoshida, S1
Bazin, H; Chattopadhyaya, J; Oberg, B; Remaud, G; Vrang, L1
Furman, PA; Langlois, AJ; Miller, WH; Richards, CA; Spector, T; St Clair, MH; Weinhold, KJ1
Kim, H; Parthasarathy, R1
Boehme, RE; Chen, MS; Chernow, M; Chuang, RY; Marx, PA; Matthews, TR; McRoberts, MJ; Prisbe, EJ; Suttmann, RT; Wu, JC1

Trials

1 trial(s) available for zidovudine triphosphate and HIV

ArticleYear
Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons.
    AIDS (London, England), 2000, Sep-29, Volume: 14, Issue:14

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cytidine Triphosphate; Dideoxynucleotides; Dose-Response Relationship, Drug; Drug Therapy, Combination; HIV; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Middle Aged; Prospective Studies; Regression Analysis; Reverse Transcriptase Inhibitors; RNA, Viral; Thymine Nucleotides; Zidovudine

2000

Other Studies

18 other study(ies) available for zidovudine triphosphate and HIV

ArticleYear
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine

1989
Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.
    Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21

    Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; HIV; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Zidovudine

2013
Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    Topics: Anti-Bacterial Agents; Anti-HIV Agents; Carboxylic Acids; DNA-Directed RNA Polymerases; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Escherichia coli; HEK293 Cells; HeLa Cells; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thiophenes

2016
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11

    Topics: Anti-HIV Agents; Cell Line; Dideoxynucleotides; Dose-Response Relationship, Drug; HeLa Cells; HIV; Humans; Phosphorylation; Reverse Transcriptase Inhibitors; Stavudine; Thymine Nucleotides; Virus Replication; Zidovudine

2007
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase.
    The Journal of biological chemistry, 1995, Aug-11, Volume: 270, Issue:32

    Topics: Antiviral Agents; Base Sequence; Deoxyribonucleotides; Dideoxynucleotides; DNA-Directed DNA Polymerase; HIV; Mitochondria; Molecular Sequence Data; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Thymine Nucleotides; Zidovudine

1995
3'-Azido-3'-deoxythymidine potently inhibits protein glycosylation. A novel mechanism for AZT cytotoxicity.
    The Journal of biological chemistry, 1994, May-20, Volume: 269, Issue:20

    Topics: Animals; CHO Cells; Cricetinae; Cytidine Monophosphate N-Acetylneuraminic Acid; Dideoxynucleotides; Glycosylation; Golgi Apparatus; HIV; HIV Infections; Humans; Intracellular Membranes; Kinetics; Membrane Proteins; Nucleoside Diphosphate Sugars; Protein Processing, Post-Translational; Thymine Nucleotides; Uridine Diphosphate Galactose; Uridine Diphosphate N-Acetylglucosamine; Zidovudine

1994
NMR study of dideoxynucleotides with anti-human immunodeficiency virus (HIV) activity.
    Journal of biochemical and biophysical methods, 1996, Feb-05, Volume: 31, Issue:3-4

    Topics: Antiviral Agents; Dideoxynucleotides; HIV; Humans; Inosine Triphosphate; Magnetic Resonance Spectroscopy; Models, Theoretical; Molecular Conformation; Molecular Structure; Thymine Nucleotides; Zidovudine

1996
Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:3

    Topics: Adult; Anti-HIV Agents; Dideoxynucleotides; Female; HIV; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Phosphorylation; Thymine Nucleotides; Zidovudine

2001
Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation.
    Biochemistry, 1992, May-12, Volume: 31, Issue:18

    Topics: Antiviral Agents; Base Sequence; Binding, Competitive; Dideoxynucleotides; HIV; Molecular Sequence Data; Oligonucleotide Probes; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Templates, Genetic; Thionucleotides; Thymine Nucleotides; Zidovudine

1992
Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA.
    The Journal of biological chemistry, 1992, Oct-25, Volume: 267, Issue:30

    Topics: Antiviral Agents; Base Sequence; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase I; DNA Polymerase II; HIV; Humans; Kinetics; Molecular Sequence Data; Terminator Regions, Genetic; Thymine Nucleotides; Zidovudine

1992
Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.
    Biochemistry, 1990, Apr-17, Volume: 29, Issue:15

    Topics: Antiviral Agents; Bacteriophages; Chemical Phenomena; Chemistry; Dideoxynucleotides; DNA; DNA-Directed DNA Polymerase; HIV; Kinetics; Models, Molecular; RNA-Directed DNA Polymerase; Templates, Genetic; Thymine Nucleotides; Zidovudine

1990
Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases.
    The Journal of biological chemistry, 1990, Jul-15, Volume: 265, Issue:20

    Topics: Antiviral Agents; Avian Myeloblastosis Virus; Base Sequence; Cell Line; Dideoxynucleotides; DNA Polymerase II; DNA Polymerase III; DNA-Directed DNA Polymerase; HIV; Humans; Molecular Sequence Data; Moloney murine leukemia virus; Nucleic Acid Synthesis Inhibitors; Oligonucleotide Probes; Reverse Transcriptase Inhibitors; Substrate Specificity; Thymine Nucleotides; Zidovudine

1990
The characterization of EIAV reverse transcriptase and its inhibition by 5'-triphosphates of 2'-deoxyuridine analogs, PFA and PAA.
    Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 1990, Volume: 5, Issue:3

    Topics: Antiviral Agents; Dideoxynucleotides; Foscarnet; HIV; Infectious Anemia Virus, Equine; Phosphonoacetic Acid; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine

1990
Mechanisms of inhibitions of DNA polymerase gamma by nucleotide analogues having anti-HIV activities.
    Nucleic acids symposium series, 1991, Issue:25

    Topics: Animals; Antiviral Agents; Cattle; Dideoxynucleotides; DNA Polymerase III; HIV; Male; Thymine Nucleotides; Zidovudine

1991
Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.
    Antiviral research, 1987, Volume: 7, Issue:3

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Dideoxynucleotides; HIV; Humans; Kinetics; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thymine Nucleotides; Zidovudine

1987
3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:12

    Topics: Anti-Bacterial Agents; Autoradiography; Cells, Cultured; Dideoxynucleotides; Electrophoresis, Polyacrylamide Gel; HIV; Nucleic Acid Synthesis Inhibitors; Peptide Chain Termination, Translational; Reverse Transcriptase Inhibitors; Substrate Specificity; Templates, Genetic; Thymine Nucleotides; Zidovudine

1987
Conformation and sandwiching of bases by azido groups in the crystal structure of 3'-azido-3'-deoxy-thymidine (AZT), an antiviral agent that inhibits HIV reverse transcriptase.
    Biochemical and biophysical research communications, 1988, Apr-15, Volume: 152, Issue:1

    Topics: Azides; Dideoxynucleotides; HIV; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Zidovudine

1988
Kinetics and inhibition of reverse transcriptase from human and simian immunodeficiency viruses.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:12

    Topics: Deoxyguanine Nucleotides; Dideoxynucleotides; HIV; Humans; Kinetics; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Thymine Nucleotides; Zidovudine

1988