Page last updated: 2024-08-23

zidovudine and Chromosome-Defective Micronuclei

zidovudine has been researched along with Chromosome-Defective Micronuclei in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (25.00)18.2507
2000's7 (58.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carneiro, CC; Carvalho, CJ; Carvalho, WF; Chen-Chen, L; Cunha, KS; Lima, DC; Moraes Filho, AV; Silva, DM; Vale, CR; Vieira, TB1
Borojerdi, JP; Braun, HM; Cooch, C; Ming, J; Olivero, OA; Poirier, MC; Semino-Mora, C; Taylor, BJ; Ward, Y; Yu, M1
Borojerdi, JP; Braun, HM; Cooch, CC; Keller, E; McKee, E; Ming, J; Olivero, OA; Poirier, MC; Vazquez, IL; Yu, M1
Beland, FA; Bishop, ME; Dobrovolsky, VN; Hamilton, LP; Heflich, RH; Shaddock, JG; Von Tungeln, LS1
Aruna, R; Jagetia, GC1
Bishop, JB; Tice, RR; Witt, KL; Wolfe, GW2
Beland, FA; Dobrovolsky, VN; Heflich, RH; McGarrity, LJ; Mittelstaedt, RA; Morris, SM; VonTungeln, LS1
Das, S; Ming, JM; Olivero, OA; Poirier, MC; Richardson, DL; Vazquez, IL; Weston, A1
Dertinger, SD; Tometsko, KR; Torous, DK1
Agarwal, RP; Olivero, OA1
Nascimbeni, B; Phillips, MD; Shelby, MD; Tice, RR1

Other Studies

12 other study(ies) available for zidovudine and Chromosome-Defective Micronuclei

ArticleYear
Genotoxic and Cytotoxic Effects of Antiretroviral Combinations in Mice Bone Marrow.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Animals; Antiretroviral Therapy, Highly Active; Bone Marrow; Comet Assay; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Lamivudine; Mice; Micronuclei, Chromosome-Defective; Tenofovir; Zidovudine

2016
Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.
    Mutation research, 2009, Jun-01, Volume: 665, Issue:1-2

    Topics: Aneugens; Aneuploidy; Animals; Aurora Kinases; Breast; Cell Cycle; Cell Line; Centrosome; CHO Cells; Cricetinae; Cricetulus; DNA Adducts; Epithelial Cells; Humans; Micronuclei, Chromosome-Defective; Microscopy, Electron, Transmission; Protein Serine-Threonine Kinases; Tubulin; Zidovudine

2009
Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 115, Issue:1

    Topics: Anti-HIV Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA; DNA Adducts; Down-Regulation; Drug Resistance, Neoplasm; Humans; Micronuclei, Chromosome-Defective; Micronucleus Tests; Phosphorylation; T-Lymphocytes; Thymidine; Thymidine Kinase; Zidovudine

2010
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine.
    Carcinogenesis, 2002, Volume: 23, Issue:9

    Topics: Animals; Anti-HIV Agents; Bone Marrow; Bromodeoxyuridine; Drug Interactions; Drug Resistance, Neoplasm; Erythrocytes; Female; Gene Frequency; Hypoxanthine Phosphoribosyltransferase; Lamivudine; Loss of Heterozygosity; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronuclei, Chromosome-Defective; Mutation; Thymidine Kinase; Zidovudine

2002
Correlation of micronuclei-induction with the cell survival in HeLa cells treated with a base analogue, azidothymidine (AZT) before exposure to different doses of gamma-radiation.
    Toxicology letters, 2003, Mar-20, Volume: 139, Issue:1

    Topics: Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Gamma Rays; HeLa Cells; Humans; Logistic Models; Micronuclei, Chromosome-Defective; Zidovudine

2003
Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage.
    Environmental and molecular mutagenesis, 2004, Volume: 43, Issue:1

    Topics: Administration, Oral; Animals; Anti-HIV Agents; Didanosine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Erythrocytes; Female; Lactation; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagens; Pregnancy; Prenatal Exposure Delayed Effects; Time Factors; Zidovudine

2004
Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment.
    Environmental and molecular mutagenesis, 2004, Volume: 44, Issue:4

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-HIV Agents; Didanosine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Erythrocytes; Female; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Pregnancy; Prenatal Exposure Delayed Effects; Zidovudine

2004
Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice.
    Mutation research, 2005, Mar-01, Volume: 570, Issue:2

    Topics: Animals; Erythrocytes; Flow Cytometry; Genotype; Mice; Micronuclei, Chromosome-Defective; Thymidine Kinase; Zidovudine

2005
Human inter-individual variability in metabolism and genotoxic response to zidovudine.
    Toxicology and applied pharmacology, 2008, Apr-15, Volume: 228, Issue:2

    Topics: Apoptosis; Bleomycin; Blotting, Western; Cell Cycle; Cell Line; Cell Survival; Cells, Cultured; DNA; Epithelial Cells; Flow Cytometry; Humans; Interphase; Mammary Glands, Human; Micronuclei, Chromosome-Defective; Radioimmunoassay; Reverse Transcriptase Inhibitors; Thymidine Kinase; Time Factors; Zidovudine

2008
Induction of micronuclei by low doses of azidothymidine (AZT).
    Mutation research, 1996, Jul-05, Volume: 368, Issue:3-4

    Topics: Animals; Antiviral Agents; Female; Flow Cytometry; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; Zidovudine

1996
Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine.
    Mutation research, 1997, May-23, Volume: 390, Issue:3

    Topics: Anti-HIV Agents; Cell Nucleus; Cells, Cultured; Chromosome Aberrations; DNA Adducts; DNA Damage; DNA, Mitochondrial; Humans; Lactic Acid; Lipid Metabolism; Micronuclei, Chromosome-Defective; Mitochondria; Mutagenicity Tests; Radioimmunoassay; T-Lymphocytes; Zidovudine

1997
Induction of micronuclei in mouse bone marrow cells: an evaluation of nucleoside analogues used in the treatment of AIDS.
    Environmental and molecular mutagenesis, 1991, Volume: 18, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Animals; Antiviral Agents; Bone Marrow; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Micronuclei, Chromosome-Defective; Micronucleus Tests; Molecular Structure; Mutagenicity Tests; Mutagens; Nucleosides; Zidovudine

1991