Compounds > zidovudine
Page last updated: 2024-08-23

zidovudine and Acute Liver Injury, Drug-Induced

zidovudine has been researched along with Acute Liver Injury, Drug-Induced in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.56)18.7374
1990's11 (28.21)18.2507
2000's10 (25.64)29.6817
2010's16 (41.03)24.3611
2020's1 (2.56)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Abongwa, LE; Bella, S; Charles, F; Domkam, I; Emmanuel, N; Eyongetah, M; Jude, B; Moungang, EC; Mua, FH; Ngum, V; Nyamache, AK; Okemo, P; Tamboh, TC; Torimiro, J1
Chen, X; Fairley, CK; He, J; Jing, J; Mao, L; Sasadeusz, J; Su, S; Wei, X; Zeng, H; Zhang, L1
Davis, K; Fabian, E; Greenhaw, J; Groeters, S; Herold, M; Kamp, H; Looser, R; Marxfeld, H; Mattes, W; Mellert, W; Moeller, N; Montoya-Parra, G; Prokoudine, A; Strauss, V; van Ravenzwaay, B; Walk, T1
Bekolo, CE; Bekoule, PS; Djidjou, H; Kollo, B; Sonkoue, C1
Bhavani, G; Ezhilarasan, D; Jesudas, B; Karthikeyan, S; Raghu, R1
Karthikeyan, S; Raghu, R1
Bazarbachi, A; de Thé, H; El Hajj, H; Farid, R; Hatoum, H; Hermine, O; Kchour, G; Kooshyar, MM; Mahmoudi, M; Maleki, M; Rafatpanah, H; Rahimi, H; Rezaee, SA; Shirdel, A; Tarhini, M; Wattel, E; Yazdi, MT1
Adesina, EA; Agbaje, EO; Akintonwa, A; Awodele, O1
Brunet, C; Bui, E; De Saint Martin, L; Jovelin, T; Le Moal, G; Perfezou, P; Raffi, F; Reliquet, V; Venisse, N; Winer, N1
Agbaji, O; Ekong, E; Graham, C; Hawkins, C; Idoko, J; Kanki, P; Meloni, S; Muazu, M; Murphy, R; Nimzing, L; Sankalé, JL; Thio, CL1
Bouhour, D; Dumouchel-Champagne, H; Durupt, F; Ferry, T; Granier, P1
Girault, V1
Bentley, AT; Lynx, MD; McKee, EE1
Abdoulaye, D; André, C; André, E; Bernard, L; Sandrine, PF; Sylvie, A1
Ali, IY; Gaikwad, AB; Gupta, J; Tamta, A; Tikoo, K1
Amato, DA; DeGruttola, V; Eyster, ME; Gjerset, GF; Ho, M; Kessler, CM; LoFaro, ML; Parenti, DM; Ragni, MV; Van Der Horst, C1
Ameer, B1
Chapnick, EK; Gradon, JD; Sepkowitz, DV2
Acosta, EP; Henry, K; Jochimsen, E1
Borucki, MJ; Haque, AK; Olano, JP; Wen, JW1
Abad, M; Alonso, MJ; Corcuera, T; Gómez, F; López-Bravo, A; Muñoz, E; Picazo, A; Roldán, M1
Aoki, M; Genka, I; Kikuchi, Y; Oka, S; Tachikawa, N; Teruya, K; Yamaguchi, M; Yamamoto, Y; Yasuoka, A; Yasuoka, C1
Koranyi, K; Nahata, MC; Pai, VB1
Espiridião SKulay, L; Mamede, JA; Mora, OA; Oliveira-Filho, RM; Simo s, MJ1
Carr, A; Mallon, P; Morey, A; Thorburn, DR; Williams, D1
Goetz, MB; Shriner, K1
Barker, SM; Chen, SC; Cunningham, AL; Mitchell, DH; O'Neill, P; Stevens, SM1
Bozzette, S; Connor, JD; Dieterich, D; Hochster, H; Liebes, L; Pettinelli, C; Reichman, RC; Sonke, RL; Spector, SA; Valentine, F1
Braffman, MN; Dubin, G1

Reviews

2 review(s) available for zidovudine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[The treatment of HIV infection].
    Presse medicale (Paris, France : 1983), 2005, Nov-19, Volume: 34, Issue:20 Pt 2

    Topics: Adenine; Anti-Retroviral Agents; Carbamates; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Therapy, Combination; Furans; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphates; Organophosphonates; Risk Factors; Sulfonamides; Tenofovir; Zidovudine

2005

Trials

4 trial(s) available for zidovudine and Acute Liver Injury, Drug-Induced

ArticleYear
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).
    Blood, 2009, Jun-25, Volume: 113, Issue:26

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Synergism; Female; Gastrointestinal Diseases; Hematologic Diseases; Human T-lymphotropic virus 1; Humans; Interferon-alpha; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Oxides; Proviruses; Remission Induction; Viral Load; Zidovudine

2009
Effectiveness and safety of saquinavir/ritonavir in HIV-infected pregnant women: INEMA cohort.
    Medecine et maladies infectieuses, 2012, Volume: 42, Issue:9

    Topics: Adult; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Cohort Studies; Delivery, Obstetric; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Prospective Studies; Ritonavir; Saquinavir; Treatment Outcome; Viral Load; Viremia; Young Adult; Zidovudine

2012
Randomized study of didanosine monotherapy and combination therapy with zidovudine in hemophilic and nonhemophilic subjects with asymptomatic human immunodeficiency virus-1 infection. AIDS Clinical Trial Groups.
    Blood, 1995, May-01, Volume: 85, Issue:9

    Topics: Adult; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Didanosine; Drug Therapy, Combination; Female; Hemophilia A; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Male; Safety; Treatment Outcome; Viremia; Zidovudine

1995
Toxicity of combined ganciclovir and zidovudine for cytomegalovirus disease associated with AIDS. An AIDS Clinical Trials Group Study.
    Annals of internal medicine, 1990, Jul-15, Volume: 113, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Anemia; Chemical and Drug Induced Liver Injury; Cytomegalovirus Infections; Drug Therapy, Combination; Female; Ganciclovir; Humans; Leukopenia; Male; Middle Aged; Multicenter Studies as Topic; Neutropenia; Prospective Studies; Time Factors; Vomiting; Zidovudine

1990

Other Studies

33 other study(ies) available for zidovudine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon.
    BMC gastroenterology, 2022, Jun-03, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cameroon; Chemical and Drug Induced Liver Injury; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Risk Factors; Young Adult; Zidovudine

2022
HBV, HCV, and HBV/HCV co-infection among HIV-positive patients in Hunan province, China: Regimen selection, hepatotoxicity, and antiretroviral therapy outcome.
    Journal of medical virology, 2018, Volume: 90, Issue:3

    Topics: Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Cohort Studies; Coinfection; Cyclopropanes; Female; Hepatitis B; Hepatitis C; HIV; HIV Infections; Humans; Male; Middle Aged; Nevirapine; Retrospective Studies; Treatment Outcome; Viral Load; Zidovudine

2018
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma.
    Toxicology letters, 2014, Nov-04, Volume: 230, Issue:3

    Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Flutamide; Lamivudine; Liver; Male; Mannitol; Metabolomics; Methotrexate; Neomycin; Oxidative Stress; Phenytoin; Piperazines; Propylthiouracil; Rats; Rats, Wistar; Streptomycin; Triazoles; Valproic Acid; Vancomycin; Zidovudine

2014
Evaluating the utility of early laboratory monitoring of antiretroviral-induced haematological and hepatic toxicity in HIV-infected persons in Cameroon.
    BMC infectious diseases, 2014, Sep-25, Volume: 14

    Topics: Adult; Anemia; Anti-HIV Agents; Cameroon; Chemical and Drug Induced Liver Injury; Early Diagnosis; Female; HIV Infections; Humans; Male; Middle Aged; Prevalence; Retrospective Studies; Stavudine; Zidovudine

2014
Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in rats.
    Human & experimental toxicology, 2015, Volume: 34, Issue:11

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-HIV Agents; Catalase; Chemical and Drug Induced Liver Injury; Fatty Acids, Nonesterified; Female; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Oxidative Stress; Protective Agents; Rats, Wistar; Silybin; Silymarin; Zidovudine

2015
Zidovudine and isoniazid induced liver toxicity and oxidative stress: Evaluation of mitigating properties of silibinin.
    Environmental toxicology and pharmacology, 2016, Volume: 46

    Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Isoniazid; Liver Function Tests; Male; Oxidative Stress; Rats, Wistar; Silybin; Silymarin; Zidovudine

2016
Hepatoprotective role of neutrosecR on hepatic damage induced by combination of zidovudine and combined anti-tuberculous agents in rats.
    The Tokai journal of experimental and clinical medicine, 2011, Jul-20, Volume: 36, Issue:2

    Topics: Amino Acids; Animals; Anti-HIV Agents; Antioxidants; Antitubercular Agents; Catalase; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drug Combinations; Drug Therapy, Combination; Liver; Liver Function Tests; Protective Agents; Rats; Vitamins; Zidovudine

2011
Impact of hepatitis C virus on HIV response to antiretroviral therapy in Nigeria.
    Journal of acquired immune deficiency syndromes (1999), 2013, Feb-01, Volume: 62, Issue:2

    Topics: Adult; Alanine Transaminase; Alkynes; Anti-Retroviral Agents; Benzoxazines; Chemical and Drug Induced Liver Injury; Coinfection; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Lamivudine; Logistic Models; Male; Nevirapine; Nigeria; Organophosphorus Compounds; RNA, Viral; Stavudine; Zidovudine

2013
[Hypersensitive reaction to abacavir or syphilitic hepatitis?].
    Presse medicale (Paris, France : 1983), 2003, Oct-11, Volume: 32, Issue:33

    Topics: Adult; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; Ethylenediamines; HIV Seropositivity; Humans; Lamivudine; Male; Syphilis; Zidovudine

2003
3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.
    Biochemical pharmacology, 2006, Apr-28, Volume: 71, Issue:9

    Topics: Animals; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Kinetics; Liver Diseases; Mitochondria, Liver; Phosphorylation; Rats; Rats, Sprague-Dawley; Thymidine; Zidovudine

2006
Nodular regenerative hyperplasia: a new serious antiretroviral drugs side effect?
    AIDS (London, England), 2007, Jul-11, Volume: 21, Issue:11

    Topics: Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Chemical and Drug Induced Liver Injury; Didanosine; Female; HIV Infections; HIV-1; Humans; Hyperplasia; Liver; Liver Diseases; Liver Regeneration; Middle Aged; Nevirapine; Zidovudine

2007
Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation.
    Toxicology letters, 2008, Mar-15, Volume: 177, Issue:2

    Topics: Acetylation; Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-HIV Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA Damage; Glycoside Hydrolases; Histones; Liver; Liver Diseases; Malondialdehyde; Mice; Micronucleus Tests; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Tannins; Zidovudine

2008
Acetaminophen hepatotoxicity augmented by zidovudine.
    The American journal of medicine, 1993, Volume: 95, Issue:3

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Humans; Rats; Zidovudine

1993
Immunosuppressive effect of zidovudine.
    Annals of internal medicine, 1993, Apr-01, Volume: 118, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Humans; Zidovudine

1993
Hepatotoxicity and rash associated with zidovudine and zalcitabine chemoprophylaxis.
    Annals of internal medicine, 1996, May-01, Volume: 124, Issue:9

    Topics: Chemical and Drug Induced Liver Injury; Erythema; Female; HIV Infections; Humans; Middle Aged; Zalcitabine; Zidovudine

1996
Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:4

    Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; Alanine Transaminase; Bilirubin; Chemical and Drug Induced Liver Injury; Fat Necrosis; Fatal Outcome; Female; Humans; L-Lactate Dehydrogenase; Liver Diseases; Zidovudine

1995
Hepatic Morphological alterations induced by zidovudine (ZDV) in an experimental model.
    Pathology, research and practice, 1996, Volume: 192, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Microscopy, Electron; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Time Factors; Zidovudine

1996
Mitigation of hepato-cellular injury caused by HAART with glycyrrhizin compound in patients co-infected with HIV and HCV.
    Japanese journal of infectious diseases, 1999, Volume: 52, Issue:6

    Topics: Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug Combinations; Drug Therapy, Combination; Glycine; Glycyrrhetinic Acid; Hemophilia A; Hepatitis C; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Reverse Transcriptase Inhibitors; Stavudine; Viral Load; Zalcitabine; Zidovudine

1999
Acute hepatitis and bleeding possibly induced by zidovudine and ritonavir in an infant with HIV infection.
    Pharmacotherapy, 2000, Volume: 20, Issue:9

    Topics: Acute Disease; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Hemorrhage; HIV Infections; Humans; Infant; Male; Ritonavir; Zidovudine

2000
Serious adverse events attributed to nevirapine regimens for postexposure prophylaxis after HIV exposures--worldwide, 1997-2000.
    MMWR. Morbidity and mortality weekly report, 2001, Jan-05, Volume: 49, Issue:51-52

    Topics: Adult; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Drug Eruptions; Female; HIV Infections; Humans; Lamivudine; Liver Failure; Male; Nevirapine; Occupational Exposure; Reverse Transcriptase Inhibitors; Rhabdomyolysis; Zidovudine

2001
Hepatic and renal effects of azidothymidine and acyclovir on pregnant rats.
    Clinical and experimental obstetrics & gynecology, 2000, Volume: 27, Issue:3-4

    Topics: Abortion, Spontaneous; Acyclovir; Animals; Antiviral Agents; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Kidney; Kidney Diseases; Liver; Liver Diseases; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar; Zidovudine

2000
Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia.
    Lancet (London, England), 2001, May-05, Volume: 357, Issue:9266

    Topics: Acute Disease; Aged; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Didanosine; Fatal Outcome; Fatty Liver; HIV Infections; HIV-1; Humans; Hypertension, Portal; Male; Mitochondria, Liver; Stavudine; Zidovudine

2001
Zidovudine-induced hepatitis.
    Journal of internal medicine, 1992, Volume: 231, Issue:3

    Topics: Adult; Chemical and Drug Induced Liver Injury; HIV Infections; Humans; Male; Zidovudine

1992
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine.
    The American journal of medicine, 1992, Volume: 93, Issue:1

    Topics: Acetaminophen; Acquired Immunodeficiency Syndrome; Adult; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Zidovudine

1992
Concurrent zidovudine-induced myopathy and hepatoxicity in patients treated for human immunodeficiency virus (HIV) infection.
    Pathology, 1992, Volume: 24, Issue:2

    Topics: Adult; Chemical and Drug Induced Liver Injury; HIV Infections; Humans; Male; Muscular Diseases; Zidovudine

1992
Zidovudine-induced hepatotoxicity.
    Annals of internal medicine, 1989, Jan-01, Volume: 110, Issue:1

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Liver Function Tests; Male; Zidovudine

1989