ziconotide has been researched along with Pancreatitis* in 1 studies
1 other study(ies) available for ziconotide and Pancreatitis
| Article | Year |
|---|---|
Calcium channels blockers toxins attenuate abdominal hyperalgesia and inflammatory response associated with the cerulein-induced acute pancreatitis in rats.
Agents that modulate the activity of high-voltage gated calcium channels (HVCCs) exhibit experimentally and clinically significant effect by relieving visceral pain. Among these agents, the toxins Phα1β and ω-conotoxin MVIIA effectively reduce chronic pain in rodent models. The molecular mechanisms underlying the chronic pain associated with acute pancreatitis (AP) are poorly understood. Hypercalcemia is a risk factor; the role of cytosolic calcium is considered to be a modulator of pancreatitis. Blockade of Ca Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Ceruletide; Disease Models, Animal; Exploratory Behavior; Hyperalgesia; Inflammation Mediators; Male; Neuropeptides; omega-Conotoxins; Pain Threshold; Pancreas; Pancreatitis; Rats, Wistar; Spider Venoms; Spinal Cord | 2021 |