zerumbone and Neuralgia

zerumbone has been researched along with Neuralgia* in 2 studies

Other Studies

2 other study(ies) available for zerumbone and Neuralgia

ArticleYear
Zerumbone Ameliorates Neuropathic Pain Symptoms via Cannabinoid and PPAR Receptors Using In Vivo and In Silico Models.
    Molecules (Basel, Switzerland), 2021, Jun-24, Volume: 26, Issue:13

    Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the

    Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Neuralgia; PPAR alpha; PPAR gamma; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sesquiterpenes

2021
Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain.
    Fitoterapia, 2015, Volume: 105

    Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kgi.p.) and morphine (1 mg/kgi.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis.

    Topics: Analgesics; Animals; Constriction; Disease Models, Animal; Hyperalgesia; Mice; Mice, Inbred ICR; Neuralgia; Pain Measurement; Rhizome; Sesquiterpenes; Zingiberaceae

2015