zeneca zd 6169 has been researched along with Muscle Contraction in 18 studies
*Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 14 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, FJ; Ceccarelli, C; Chun, AL; Empfield, JR; Forst, JM; Frank, CA; Gibson, KH; Grant, TL; Harris, RJ; Howe, BB; Hulsizer, JM; Kau, ST; Lewis, JJ; Lin, MM; Masek, BB; Mayhugh, DR; McLaren, FM; Neilson, KL; Ohnmacht, CJ; Russell, K; Shapiro, HS; Silverman, SM; Smith, RW; Trainor, DA; Warwick, PJ | 1 |
| Antane, MM; Antane, SA; Argentieri, TM; Butera, JA; Freeden, C; Graceffa, RF; Hirth, BH; Jenkins, D; Lennox, JR; Matelan, E; Norton, NW; Quagliato, D; Sheldon, JH; Spinelli, W; Warga, D; Wojdan, A; Woods, M | 1 |
| Antane, MM; Argentieri, TM; Butera, JA; Francisco, GD; Freeden, C; Gilbert, AM; Graceffa, RF; Gundersen, EG; Herbst, D; Hirth, BH; Lennox, JR; McFarlane, G; Norton, NW; Quagliato, D; Sheldon, JH; Warga, D; Wojdan, A; Woods, M | 1 |
| Brune, ME; Buckner, SA; Carroll, WA; Castle, NA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Milicic, I; Scott, VE; Sullivan, JP; Turner, SC; White, TK | 1 |
| Altenbach, RJ; Bai, H; Brioni, JD; Brune, ME; Buckner, SA; Carroll, WA; Cassidy, C; Chen, Y; Coghlan, MJ; Daza, AV; Drizin, I; Fey, TA; Fitzgerald, M; Gopalakrishnan, M; Gregg, RJ; Henry, RF; Holladay, MW; King, LL; Kort, ME; Kym, PR; Milicic, I; Sullivan, JP; Tang, R; Turner, SC; Whiteaker, KL; Yi, L; Zhang, H | 1 |
| Altenbach, RJ; Brune, ME; Buckner, SA; Carroll, WA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Henry, RF; Khilevich, A; Kort, ME; Milicic, I; Scott, VE; Smith, JC; Whiteaker, KL | 1 |
| Cheng, CY; Hsin, LW; Liang, PH | 1 |
| Brioni, JD; Brune, ME; Carroll, WA; Coghlan, MJ; Fey, TA; Gopalakrishnan, M; Sullivan, JP; Williams, M | 1 |
| Brioni, JD; Buckner, SA; Carroll, WA; Chapple, CR; Chess-Williams, R; Coghlan, MJ; Davis-Taber, R; Daza, AV; Gopalakrishnan, M; Liu, D; Liu, Y; Milicic, I; Molinari, EJ; Scott, VE; Sellers, D; Shieh, CC; Sullivan, JP; Whiteaker, KL; Williams, M | 1 |
| Brioni, JD; Brune, ME; Coghlan, MJ; Fabiyi, AC; Gopalakrishnan, M; Lynch, JJ | 1 |
| Brioni, JD; Brune, ME; Coghlan, MJ; Cox, BF; King, LL; Lubbers, NL; Lynch, JJ; Polakowski, JS; Sullivan, JP | 1 |
| Calzadilla, SV; Cox, BF; Fryer, RM; Gopalakrishnan, M; Hu, Y; Lin, CT; Marsh, KC; Preusser, LC; Reinhart, GA; Xu, H | 1 |
| Bolego, C; Cignarella, A; Pinna, C; Puglisi, L; Sanvito, P | 1 |
| Brune, ME; Buckner, SA; Coghlan, M; Daza, A; Fey, TA; Gopalakrishnan, M; Milicic, I | 1 |
| Bertelsen, DL; Chun, A; Kau, S; Levin, RM; Murphy, J | 1 |
| Antane, MM; Antane, SA; Argentieri, TM; Butera, JA; Colatsky, TJ; Freeden, C; Norton, NW; Oshiro, G; Sheldon, JH; Spinelli, W; Warga, D; Wojdan, A; Woods, M | 1 |
| de Groat, WC; Yu, Y | 1 |
| Bonev, AD; Heppner, TJ; Herrera, GM; Nelson, MT; Petkov, GV | 1 |
18 other study(ies) available for zeneca zd 6169 and Muscle Contraction
| Article | Year |
|---|---|
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
Topics: Amides; Animals; Cricetinae; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Rats; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence | 1996 |
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cyclobutanes; Drug Design; Drug Evaluation, Preclinical; Female; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitriles; Patch-Clamp Techniques; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence | 2000 |
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones.
Topics: Adenosine Triphosphate; Animals; Benzylamines; Blood Pressure; Cyclobutanes; Drug Design; Drug Evaluation, Preclinical; Female; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence | 2000 |
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Topics: Amides; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Cell Line; Fluorescent Dyes; Humans; Hypertrophy; Male; Membrane Potentials; Muscle Contraction; Naphthalenes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Receptors; Swine; Transfection; Urinary Bladder | 2003 |
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)
Topics: Adenosine Triphosphate; Animals; Cyclic S-Oxides; Electric Stimulation; Guinea Pigs; Hemodynamics; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Quinolones; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder; Urodynamics | 2004 |
Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.
Topics: Adenosine Triphosphate; Animals; Aza Compounds; Cell Line; Crystallography, X-Ray; Dihydropyridines; Electric Stimulation; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Ion Channel Gating; Mice; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels, Inwardly Rectifying; Stereoisomerism; Structure-Activity Relationship; Swine; Urinary Bladder | 2006 |
N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers.
Topics: Amides; Animals; Benzophenones; Ion Channel Gating; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Portal Vein; Potassium Channels; Pyrrolidinones; Rats; Rats, Wistar; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence | 2002 |
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. II. in vivo characterization.
Topics: Amides; Animals; ATP-Binding Cassette Transporters; Benzophenones; Cyclic S-Oxides; Cyclobutanes; Ion Channel Gating; KATP Channels; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitriles; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinolones; Swine; Urinary Bladder | 2002 |
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization.
Topics: Amides; Animals; Aorta, Thoracic; ATP-Binding Cassette Transporters; Benzophenones; Cyclic S-Oxides; Cyclobutanes; Guinea Pigs; Humans; In Vitro Techniques; Ion Channel Gating; KATP Channels; Kinetics; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitriles; Patch-Clamp Techniques; Portal Vein; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinolones; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2002 |
In vivo evaluation of the potency and bladder-vascular selectivity of the ATP-sensitive potassium channel openers (-)-cromakalim, ZD6169 and WAY-133537 in rats.
Topics: Amides; Animals; Benzophenones; Calcium Channels; Cromakalim; Cyclobutanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Male; Muscarinic Antagonists; Muscle Contraction; Nitriles; Rats; Rats, Sprague-Dawley; Reflex, Abnormal; Urinary Bladder; Urinary Bladder Neck Obstruction; Urinary Bladder, Neurogenic; Vasodilator Agents | 2003 |
K-ATP opener-mediated attenuation of spontaneous bladder contractions in ligature-intact, partial bladder outlet obstructed rats.
Topics: Amides; Animals; ATP-Binding Cassette Transporters; Benzophenones; Blood Pressure; Cyclic S-Oxides; Cyclobutanes; Female; Heart Rate; KATP Channels; Male; Muscle Contraction; Muscle, Smooth; Nitriles; Organ Size; Plasma; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinolones; Rats; Rats, Sprague-Dawley; Telemetry; Urinary Bladder; Urinary Bladder Neck Obstruction | 2003 |
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Blood Pressure; Cyclic S-Oxides; Cyclobutanes; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrocardiography; Heart Rate; Hypotension; Infusions, Intravenous; Ion Channel Gating; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitriles; Pharmaceutical Vehicles; Polyethylene Glycols; Potassium Channels; Quinolones; Tachycardia; Urinary Bladder; Urinary Incontinence; Vascular Resistance | 2004 |
Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Blood Pressure; Carbachol; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Muscle Contraction; Pinacidil; Potassium Channels; Rats; Rats, Sprague-Dawley; Time Factors; Urethral Obstruction; Urinary Bladder | 2005 |
Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Carbachol; Cholinergic Agonists; Cromakalim; Cyclic S-Oxides; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Histamine; Hypertrophy; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyridines; Quinolones; Serotonin; Serotonin Agents; Swine; Urinary Bladder; Urinary Bladder Neck Obstruction; Vasodilator Agents | 2006 |
Comparative effects of intravesical versus extravesical administration of ZD6169 and cromakalim on the response of the in vitro rat whole bladder to field stimulation.
Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1996 |
Comparison of the potassium channel openers, WAY-133537, ZD6169, and celikalim on isolated bladder tissue and In vivo bladder instability in rat.
Topics: Amides; Animals; Benzophenones; Benzopyrans; Blood Pressure; Cyclobutanes; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Hypertrophy; In Vitro Techniques; Indoles; Male; Membrane Potentials; Molecular Structure; Muscle Contraction; Muscle, Smooth; Nitriles; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1999 |
Effects of ZD6169, a K(ATP) channel opener, on the micturition reflex in the rat.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Capsaicin; Female; Glyburide; Hypoglycemic Agents; Mechanoreceptors; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pressure; Rats; Rats, Wistar; Reflex; Urinary Bladder; Urination; Urodynamics | 1999 |
Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.
Topics: Action Potentials; Adenosine Diphosphate; Adenosine Triphosphate; Amides; Animals; Benzophenones; Cromakalim; Glyburide; Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Urinary Bladder | 2001 |