zederone and Dementia

Dementia correlates with Alzheimer's disease, Parkinson's disease, frontotemporal and cerebrovascular diseases. There are supporting shreds of evidence on the pharmacological activity of. This study aims to analyze the fecal microbial profile in Zederone treated demented rat model.. In our study, isolation and characterization of Zederone were carried out from. Zederone could be characterized as pale yellow colored, needle-shaped crystals with 96.57% purity. This compound at 10 mg/kg body weight showed cognition improving capacity (p ≤ 0.0001) with a reduction of accumulated amyloid plaques that were detected in the demented group in fluorescence microscope and fecal microbiome study divulged an increased shift towards. This sesquiterpenoid compound would assist in the modulation of gut bacterial dysbiosis and act as a better therapeutic drug for dementia and other neurological disorders.

Topics: Animals; Dementia; Dysbiosis; Female; Gastrointestinal Microbiome; Plaque, Amyloid; Rats; Rats, Wistar; Sesquiterpenes