zeaxanthin has been researched along with Vitamin-A-Deficiency* in 4 studies
1 trial(s) available for zeaxanthin and Vitamin-A-Deficiency
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β-Cryptoxanthin and zeaxanthin are highly bioavailable from whole-grain and refined biofortified orange maize in humans with optimal vitamin A status: a randomized, crossover, placebo-controlled trial.
Biofortification of staple crops with β-carotene is a strategy to reduce vitamin A deficiency, and several varieties are available in some African countries. β-Cryptoxanthin (BCX)-enhanced maize is currently in field trials. To our knowledge, maize BCX bioavailability has not been assessed in humans. Serum retinol 13C content and xanthophyll concentrations are proposed effectiveness biomarkers for biofortified maize adoption.. We determined the relative difference in BCX and zeaxanthin bioavailability from whole-grain and refined BCX-biofortified maize during chronic feeding compared with white maize and evaluated short-term changes in 13C-abundance in serum retinol.. After a 7-d washout, 9 adults (mean ± SD age: 23.4 ± 2.3 y; 5 men) were provided with muffins made from BCX-enhanced whole-grain orange maize (WGOM), refined orange maize (ROM), or refined white maize (RWM) for 12 d in a randomized, blinded, crossover study followed by a 7-d washout. Blood was drawn on days 0, 3, 6, 9, 12, 15, and 19. Carotenoid areas under the curve (AUCs) were compared by using a fixed-effects model. 13C-Abundance in serum retinol was determined by using gas chromatography/combustion/isotope-ratio mass spectrometry on days 0, 12, and 19. Vitamin A status was determined by 13C-retinol isotope dilution postintervention.. The serum BCX AUC was significantly higher for WGOM (1.70 ± 0.63 μmol ⋅ L-1 ⋅ d) and ROM (1.66 ± 1.08 μmol ⋅ L-1 ⋅ d) than for RWM (-0.06 ± 0.13 μmol ⋅ L-1 ⋅ d; P < 0.003). A greater increase occurred in serum BCX from WGOM muffins (131%) than from ROM muffins (108%) (P ≤ 0.003). Zeaxanthin AUCs were higher for WGOM (0.94 ± 0.33) and ROM (0.96 ± 0.47) than for RWM (0.05 ± 0.12 μmol ⋅ L-1 ⋅ d; P < 0.003). The intervention did not affect predose serum retinol 13C-abundance. Vitamin A status was within an optimal range (defined as 0.1-0.7 μmol/g liver).. BCX and zeaxanthin were highly bioavailable from BCX-biofortified maize. The adoption of BCX maize could positively affect consumers' BCX and zeaxanthin intakes and associated health benefits. This trial is registered at www.clinicaltrials.gov as NCT02800408. Topics: Adult; Africa; beta Carotene; Beta-Cryptoxanthin; Biological Availability; Biomarkers; Bread; Carbon Isotopes; Cross-Over Studies; Diet; Feeding Behavior; Female; Food, Fortified; Humans; Liver; Male; Nutritional Status; Provitamins; Vitamin A; Vitamin A Deficiency; Whole Grains; Young Adult; Zea mays; Zeaxanthins | 2018 |
3 other study(ies) available for zeaxanthin and Vitamin-A-Deficiency
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Impact of dietary carotenoid deprivation on macular pigment and serum concentrations of lutein and zeaxanthin.
Topics: Adult; Antioxidants; Body Mass Index; Carotenoids; Diet, Reducing; Dietary Supplements; Humans; Lutein; Macula Lutea; Male; Retinal Diseases; Retinal Pigment Epithelium; Retinal Pigments; Time Factors; Vitamin A Deficiency; Weight Loss; Xanthophylls; Zeaxanthins | 2012 |
Carotenoid status among preschool children with vitamin A deficiency in the Republic of the Marshall Islands.
Although carotenoids are known to be important dietary sources of vitamin A, there have been few epidemiological studies that have characterized the serum concentrations of major dietary carotenoids among preschool children with vitamin A deficiency. We conducted a population-based, cross-sectional study of serum pro-vitamin A carotenoids (alpha -carotene, beta-carotene, beta-cryptoxanthin), non-provitamin A carotenoids (lutein/zeaxanthin, and lycopene), and retinol among 278 children, aged 1-5 y, in the Republic of the Marshall Islands. Vitamin A deficiency was defined as serum retinol <0.70 micromol/L. Geometric mean serum concentrations of carotenoids among children with and without vitamin A deficiency were 0.003 vs 0.006 micromol/L for alpha-carotene (P = 0.0017), 0.011 vs 0.023 micromol/L for beta-carotene (P <0.0001), 0.023 vs 0.034 micromol/L for beta-cryptoxanthin (P = 0.0075), 0.007 vs 0.012 micromol/L for lycopene (P = 0.037), 0.044 vs 0.052 micromol/L for lutein/zeaxanthin (P = 0.2), and 0.045 vs 0.074 micromol/L for total provitamin A carotenoids (P <0.0001) respectively. In a multivariate analysis adjusting for sex, age (Odds Ratio [O.R.] 1.44, 95% confidence interval [C.I.] 1.16-1.78), and serum provitamin A carotenoids (O.R. 0.49, 95% C.I. 0.34-0.71) were associated with vitamin A deficiency, but serum non-provitamin A carotenoids were not associated with vitamin A deficiency (O.R. 0.93, 95% C.I. 0.67-1.28). Preschool children with vitamin A deficiency in the Republic of the Marshall Islands have extremely low serum concentrations of provitamin A carotenoids and interventions are needed to improve the dietary intake of provitamin A carotenoids among Marshallese children. Topics: Antioxidants; beta Carotene; Biomarkers; Carotenoids; Child; Child Welfare; Child, Preschool; Cross-Sectional Studies; Cryptoxanthins; Female; Humans; Infant; Infant Welfare; Lutein; Lycopene; Male; Micronesia; Multivariate Analysis; Vitamin A; Vitamin A Deficiency; Xanthophylls; Zeaxanthins | 2004 |
Provitamin A activities and physiological functions of carotenoids in animals. Relevance to human health.
Topics: Animals; beta Carotene; beta-Carotene 15,15'-Monooxygenase; Carotenoids; Chickens; Epithelium; Female; Growth; Humans; Intestinal Mucosa; Liver; Lutein; Lycopene; Ovariectomy; Oxygenases; Rats; Rats, Inbred Strains; Vagina; Vaginal Diseases; Vitamin A; Vitamin A Deficiency; Xanthophylls; Zeaxanthins | 1993 |