zearalenone and Osteoarthritis--Knee

Previous studies suggest the presence of an association of vascular endothelial growth factor (VEGF) with osteoarthritis (OA) severity and pain in patients with knee OA. VEGF expression in human synovial fibroblasts (SFs) is induced by transforming growth factor-beta (TGF. OA patients who underwent total knee arthroplasty had their synovial tissue (SYT) extracted and the constituent SFs cultured. The cells were stimulated with culture medium (control), human recombinant TGF. ALK5 (SB505124) and TAK1 (5Z-oxozeaenol) inhibitors completely suppressed TGF. TGF

Topics: Cells, Cultured; Fibroblasts; Humans; Imidazoles; MAP Kinase Kinase Kinases; Osteoarthritis, Knee; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Smad2 Protein; Synovial Membrane; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Zearalenone