zd0947 and Disease-Models--Animal

zd0947 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for zd0947 and Disease-Models--Animal

Article	Year
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 A novel series of benzopyran derivatives were synthesized and evaluated as K(ATP) channel openers. Structure-activity relationships were investigated around 4-position of the benzopyran nucleus. Optimization of 4-substituent with some heterocyclic rings led to compound 13b bearing a benzo[d]isoxazol-3-one moiety as a potent and selective K(ATP) channel opener in vitro. In two anesthetized rat models of myogenic bladder overactivity, compound 13b was found to inhibit spontaneous bladder contractions. Topics: Animals; Benzopyrans; Disease Models, Animal; Potassium Channels, Inwardly Rectifying; Rats; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence, Urge	2009

Article

Year

Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.

Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2

A novel series of benzopyran derivatives were synthesized and evaluated as K(ATP) channel openers. Structure-activity relationships were investigated around 4-position of the benzopyran nucleus. Optimization of 4-substituent with some heterocyclic rings led to compound 13b bearing a benzo[d]isoxazol-3-one moiety as a potent and selective K(ATP) channel opener in vitro. In two anesthetized rat models of myogenic bladder overactivity, compound 13b was found to inhibit spontaneous bladder contractions.

Topics: Animals; Benzopyrans; Disease Models, Animal; Potassium Channels, Inwardly Rectifying; Rats; Structure-Activity Relationship; Urinary Bladder; Urinary Incontinence, Urge

2009