zd 7288 and Disease Models, Animal

Topics: Action Potentials; Animals; Cerebellar Ataxia; Disease Models, Animal; Gene Knock-In Techniques; Membrane Potentials; Mice, Transgenic; Migraine Disorders; Pyrimidines; Receptors, Purinergic P2X3; Sensory Receptor Cells; Trigeminal Ganglion

Topics: Animals; Baclofen; Benzazepines; Brain-Derived Neurotrophic Factor; Cardiotonic Agents; Disease Models, Animal; Dopaminergic Neurons; Functional Laterality; GABA-B Receptor Agonists; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Neuralgia; Nociception; Pain Threshold; Proto-Oncogene Proteins c-fos; Pyrimidines; Reward

Topics: Analgesics; Animals; Cardiotonic Agents; Chronic Pain; Colon; Disease Models, Animal; Electromyography; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Irritable Bowel Syndrome; Male; Muscle, Skeletal; Pain; Pain Threshold; Pyrimidines; Rats; Rats, Sprague-Dawley; Visceral Pain

Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Disease Models, Animal; Down-Regulation; Long-Term Potentiation; Male; Neurons; Pyrimidines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses

Topics: Animals; Astrocytes; Brain; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; In Vitro Techniques; Ischemia; Male; Membrane Potentials; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Pyrimidines; Rats; Rats, Wistar; Sodium

Topics: Amines; Animals; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lectins; Neuralgia; Pain Threshold; Pyrimidines; Radiculopathy; Rats; Rats, Wistar; Reaction Time; Spinal Nerves

Topics: Animals; Cardiovascular Agents; Cerebral Cortex; Dendrites; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lysine; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; Pain Measurement; Potassium Channels; Pyrimidines; Receptors, Serotonin; Serotonin; Serotonin Agents; Time Factors

Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lamotrigine; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Neural Inhibition; Neurofibromatosis 1; Neurofibromin 1; Neuronal Plasticity; Neurons; Potassium Channels; Pyrimidines; Signal Transduction; Triazines

Topics: Animals; Cerebral Cortex; Disease Models, Animal; Essential Tremor; Gene Expression; Genetic Heterogeneity; Genetic Loci; Hippocampus; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Hypothalamus; Inheritance Patterns; Mutation, Missense; Neurons; Potassium Channel Blockers; Potassium Channels; Proto-Oncogene Proteins c-fos; Pyrimidines; Rats; Rats, Transgenic; Signal Transduction; Stereotaxic Techniques; Thalamus

Topics: Animals; Antiparkinson Agents; Cardiovascular Agents; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; Globus Pallidus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Indoles; Kynurenic Acid; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Subthalamic Nucleus; Wakefulness

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; CA1 Region, Hippocampal; Capsaicin; Disease Models, Animal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Male; Memory Disorders; Nerve Net; Neurons; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Wistar; Sensory System Agents; TRPV Cation Channels

Topics: Animals; Biophysical Phenomena; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Neuralgia; Pain Measurement; Pain Threshold; Prefrontal Cortex; Pyramidal Cells; Pyrimidines; Rats; Rats, Long-Evans; Sodium Channel Blockers; Synaptic Potentials; Tetrodotoxin

Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Bee Venoms; Biological Clocks; Cardiovascular Agents; Cations; Disease Models, Animal; Guinea Pigs; Heart Rate; Parasympathetic Nervous System; Potassium; Potassium Channel Blockers; Pyrimidines; Sinoatrial Node; Vagus Nerve; Vagus Nerve Stimulation

Topics: Animals; Biophysics; Calcium; Disease Models, Animal; Female; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Inflammation; Membrane Potentials; Nerve Fibers, Unmyelinated; Neural Conduction; Neurons; Pain; Pain Threshold; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Sprague-Dawley

Topics: Animals; Cell Membrane; Disease Models, Animal; Female; Ion Channel Gating; Ion Channels; Male; Membrane Potentials; Mesencephalon; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Neurons; Protein Subunits; Pyrimidines; Rett Syndrome; Sodium Channels; Trigeminal Nerve

Topics: Animals; Cardiovascular Agents; Cell Death; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Lamotrigine; Male; Membrane Potentials; Patch-Clamp Techniques; Pyramidal Cells; Pyrimidines; Rats; Statistics, Nonparametric; Triazines

Topics: Animals; Basal Ganglia; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dopamine; Gene Expression; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Oxidopamine; Parkinsonian Disorders; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation

Topics: Amines; Analgesics; Animals; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Injections, Spinal; Male; Pain; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley

Topics: Animals; Cardiotonic Agents; Chronic Disease; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Neurologic Mutants; Nerve Fibers; Pain Measurement; Patch-Clamp Techniques; Presynaptic Terminals; Pyrimidines; Sciatica; Sodium Channel Blockers; Spinal Cord; Tetrodotoxin

Topics: Adrenergic beta-Agonists; Animals; Caffeine; Calcium Signaling; Cardiac Pacing, Artificial; Circadian Clocks; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Heart Failure; Heart Rate; Isoproterenol; Membrane Potentials; Perfusion; Pyrimidines; Sarcoplasmic Reticulum; Sinoatrial Node; Time Factors

Topics: Action Potentials; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Benzazepines; Brain; Cardiotonic Agents; Chronic Disease; Disease Models, Animal; Disease Susceptibility; Dopamine; Electric Stimulation; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neurons; Patch-Clamp Techniques; Pyrimidines; Reward; Stress, Psychological; Ventral Tegmental Area

Topics: Action Potentials; Animals; Biophysical Phenomena; Biophysics; Cardiovascular Agents; Chi-Square Distribution; Disease Models, Animal; Double-Blind Method; Elapid Venoms; Electric Stimulation; Female; Fourier Analysis; Ganglia, Spinal; Hyperalgesia; Male; Patch-Clamp Techniques; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sodium Channel Blockers; Spinal Cord Compression; Tetrodotoxin; Time Factors

Topics: Animals; Cell Separation; Cell Size; Cesium; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Electric Stimulation; Electrophysiology; Female; Ganglia, Spinal; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Membrane Potentials; Models, Neurological; Nerve Compression Syndromes; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley

Topics: 2-Amino-5-phosphonovalerate; Animals; Blotting, Western; Brain; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Impedance; Epilepsy, Absence; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Ion Channel Gating; Ion Channels; Male; Membrane Potentials; Neocortex; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Inbred Strains; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Species Specificity

Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Male; Neural Inhibition; Neuralgia; Neurons; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors

Topics: Animals; Axotomy; Cardiovascular Agents; Cations; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Ion Channels; Ligation; Male; Nerve Fibers, Myelinated; Neuralgia; Neurons, Afferent; Pain Threshold; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Pyrimidines; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Spinal Nerves

Topics: Action Potentials; Animals; Auditory Pathways; Brain Stem; Cardiotonic Agents; Cell Membrane; Deafness; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Excitatory Postsynaptic Potentials; Membrane Potentials; Mice; Mice, Neurologic Mutants; Models, Neurological; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Sensory Deprivation; Synapses; Synaptic Transmission

Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenine; Animals; Blotting, Northern; Cerebral Cortex; Cesium; Chlorides; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Electroencephalography; Enzyme Inhibitors; Epilepsy, Absence; Female; Gene Expression Regulation; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Microinjections; Neurons; Patch-Clamp Techniques; Potassium Channels; Protein Isoforms; Pyrimidines; Rats; Rats, Mutant Strains; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thalamus

Topics: Animals; Animals, Newborn; Computer Simulation; Craniocerebral Trauma; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Models, Neurological; Mossy Fibers, Hippocampal; Nerve Net; Neurons; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Pyrazoles; Pyrimidines; Rats; Sodium Channel Blockers; Tetraethylammonium; Tetrodotoxin

Topics: Acute Disease; Animals; Cardiovascular Agents; Chronic Disease; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Mechanoreceptors; Merkel Cells; Nociceptors; Pain; Peripheral Nerves; Potassium Channels; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Skin