zd-6126 and Melanoma

zd-6126 has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for zd-6126 and Melanoma

Article	Year
High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow. Cancer research, 2002, Nov-15, Volume: 62, Issue:22 The effect of antivascular therapy on blood flow in superficial tumors was monitored using novel high frequency Doppler (HFD) ultrasound techniques. Human melanoma cells (MeWo) were injected orthotopically into the skin of athymic nude mice. Volumetric HFD imaging of established melanomas detected a significant reduction in blood flow 4 h after injection of the tumor vascular targeting agent ZD6126 followed by a recovery of flow by 24 h after injection. Measurements of tumor perfusion in situ by Hoechst 33342 staining correlated with the ultrasound results. This study demonstrates the feasibility of HFD as a noninvasive, quantitative tool for following longitudinally the effects of antivascular therapy on blood flow in superficial tumors. Topics: Angiogenesis Inhibitors; Animals; Benzimidazoles; Humans; Melanoma; Mice; Mice, Nude; Neovascularization, Pathologic; Organophosphorus Compounds; Staining and Labeling; Tumor Cells, Cultured; Ultrasonics; Ultrasonography; Xenograft Model Antitumor Assays	2002

Article

Year

High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow.

Cancer research, 2002, Nov-15, Volume: 62, Issue:22

The effect of antivascular therapy on blood flow in superficial tumors was monitored using novel high frequency Doppler (HFD) ultrasound techniques. Human melanoma cells (MeWo) were injected orthotopically into the skin of athymic nude mice. Volumetric HFD imaging of established melanomas detected a significant reduction in blood flow 4 h after injection of the tumor vascular targeting agent ZD6126 followed by a recovery of flow by 24 h after injection. Measurements of tumor perfusion in situ by Hoechst 33342 staining correlated with the ultrasound results. This study demonstrates the feasibility of HFD as a noninvasive, quantitative tool for following longitudinally the effects of antivascular therapy on blood flow in superficial tumors.

Topics: Angiogenesis Inhibitors; Animals; Benzimidazoles; Humans; Melanoma; Mice; Mice, Nude; Neovascularization, Pathologic; Organophosphorus Compounds; Staining and Labeling; Tumor Cells, Cultured; Ultrasonics; Ultrasonography; Xenograft Model Antitumor Assays

2002