zardaverine has been researched along with Inflammation in 3 studies
zardaverine: structure given in first source
zardaverine : A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zardaverine is shown to inhibit selectively two out of five isoenzyme classes of phosphodiesterases, namely PDE III from human platelets and PDE IV from human polymorphonuclear leucocytes (PMN) with IC50 values of 0." | 2.38 | Zardaverine: a cyclic AMP specific PDE III/IV inhibitor. ( Beume, R; Eltze, M; Kilian, U; Schudt, C; Winder, S, 1991) |
| "Zardaverine is a novel phosphodiesterase III/IV inhibitor, developed as a potential therapeutic agent for asthma." | 1.29 | The effect of zardaverine, an inhibitor of phosphodiesterase isoenzymes III and IV, on endotoxin-induced airway changes in rats. ( Joos, GF; Kips, JC; Pauwels, RA; Peleman, RA, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Kips, JC | 1 |
| Joos, GF | 1 |
| Peleman, RA | 1 |
| Pauwels, RA | 1 |
| Schudt, C | 1 |
| Winder, S | 1 |
| Eltze, M | 1 |
| Kilian, U | 1 |
| Beume, R | 1 |
1 review available for zardaverine and Inflammation
| Article | Year |
|---|---|
Zardaverine: a cyclic AMP specific PDE III/IV inhibitor.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allergens; Animals; Bronchial Diseases; Eosinophilia; Humans; I | 1991 |
2 other studies available for zardaverine and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
The effect of zardaverine, an inhibitor of phosphodiesterase isoenzymes III and IV, on endotoxin-induced airway changes in rats.
Topics: Animals; Bronchoalveolar Lavage Fluid; Endotoxins; Escherichia coli; Inflammation; Isoenzymes; Lipop | 1993 |