Page last updated: 2024-11-05

zaleplon and Depression

zaleplon has been researched along with Depression in 2 studies

zaleplon: an azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors; a hypnotic with less marked effect on psychomotor functions compared to lorazepam
zaleplon : A pyrazolo[1,5-a]pyrimidine having a nitrile group at position 3 and a 3-(N-ethylacetamido)phenyl substituent at the 7-position.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Major depressive disorder is also highly comorbid in this population, leading to further impairment."5.62Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression. ( Goldschmied, JR; Kayser, MS; Morales, KH; Sengupta, A; Sharma, A; Taylor, L; Thase, ME; Weljie, A, 2021)
"Major depressive disorder is also highly comorbid in this population, leading to further impairment."1.62Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression. ( Goldschmied, JR; Kayser, MS; Morales, KH; Sengupta, A; Sharma, A; Taylor, L; Thase, ME; Weljie, A, 2021)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Goldschmied, JR1
Sengupta, A1
Sharma, A1
Taylor, L1
Morales, KH1
Thase, ME2
Weljie, A1
Kayser, MS1
Belleville, G1
Morin, CM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A 6-week Open-Label Study of Treatment of Insomnia With Zaleplon in HIV Positive Patients With Comorbid Depression[NCT03489304]Phase 220 participants (Actual)Interventional2014-04-03Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Epworth Sleepiness Scale (ESS)

The Epworth Sleepiness Scale (ESS) is a validated sleep scale that quantifies daytime sleepiness across eight domains. The total score ranges from 0-24 where higher values indicate greater daytime sleepiness. (NCT03489304)
Timeframe: Measure at 6 weeks

Interventionscore on a scale (Mean)
Zaleplon6.5

Insomnia Severity Index (ISI)

The Insomnia Severity Index is a validated sleep scale that measures clinical insomnia severity. The total score ranges from 0-28 where higher values indicate increased severity of insomnia. (NCT03489304)
Timeframe: Measure at 6 weeks

Interventionscore on a scale (Mean)
Zaleplon11

Quick Inventory of Depressive Symptomatology (QIDS)

The Quick Inventory of Depressive Symptomatology (QIDS) is a validated mood scale that quantifies depression symptoms. The total score ranges from 0-48, where higher values indicate greater depressive symptoms. (NCT03489304)
Timeframe: Measure at 6 weeks

Interventionscore on a scale (Mean)
Zaleplon8.7

Trials

1 trial available for zaleplon and Depression

ArticleYear
Hypnotic discontinuation in chronic insomnia: impact of psychological distress, readiness to change, and self-efficacy.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2008, Volume: 27, Issue:2

    Topics: Acetamides; Adaptation, Psychological; Adult; Aged; Anxiety; Attitude to Health; Azabicyclo Compound

2008

Other Studies

1 other study available for zaleplon and Depression

ArticleYear
Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression.
    Psychopharmacology bulletin, 2021, 06-01, Volume: 51, Issue:3

    Topics: Acetamides; Depression; Depressive Disorder, Major; Humans; Pyrimidines; Quality of Life; Sleep; Sle

2021