yqa14 and Disease-Models--Animal

Post-traumatic stress disorder (PTSD) is a complicated psychiatric disorder, which occurs after exposure to a traumatic event. The main clinical manifestation of PTSD includes fear and stress dysregulation. In both animals and humans, dysregulation of dopamine function appears to be related to conditioned fear responses. Previous studies show that the dopamine D3 receptor (D3R) is involved in schizophrenia, autism, and substance use disorders and is related to emotional disorders. However, few studies have investigated the role of the D3R in the pathogenesis and aetiology of PTSD. In the current study, we have reported that D3R knockout (D3R

Topics: Animals; Anxiety; Benzoxazoles; Disease Models, Animal; Dopamine Antagonists; Electroshock; Freezing Reaction, Cataleptic; Male; Mice, Inbred C57BL; Mice, Knockout; Piperazines; Rats, Sprague-Dawley; Receptors, Dopamine D3; Stress Disorders, Post-Traumatic