ym-216391 and Neoplasms

ym-216391 has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for ym-216391 and Neoplasms

Article	Year
Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system. Organic & biomolecular chemistry, 2018, 12-12, Volume: 16, Issue:48 Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity. Topics: Amino Acid Sequence; Antineoplastic Agents; Biosynthetic Pathways; Cell Line, Tumor; Cell Survival; Genes, Bacterial; Genetic Engineering; Humans; Multigene Family; Neoplasms; Oxazoles; Peptides, Cyclic; Streptomyces; Streptomyces coelicolor	2018

Article

Year

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system.

Organic & biomolecular chemistry, 2018, 12-12, Volume: 16, Issue:48

Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.

Topics: Amino Acid Sequence; Antineoplastic Agents; Biosynthetic Pathways; Cell Line, Tumor; Cell Survival; Genes, Bacterial; Genetic Engineering; Humans; Multigene Family; Neoplasms; Oxazoles; Peptides, Cyclic; Streptomyces; Streptomyces coelicolor

2018