yil-781 has been researched along with Diabetes-Mellitus--Type-2* in 1 studies
1 other study(ies) available for yil-781 and Diabetes-Mellitus--Type-2
Article | Year |
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Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity.
Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and LogD lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG. Topics: Administration, Oral; Animals; Aza Compounds; Biological Availability; Diabetes Mellitus, Type 2; Drug Design; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Kinetics; Male; Obesity; Quinazolinones; Rats; Rats, Sprague-Dawley; Receptors, Ghrelin; Structure-Activity Relationship | 2012 |