yf-476 has been researched along with Adenocarcinoma* in 1 studies
1 other study(ies) available for yf-476 and Adenocarcinoma
Article | Year |
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Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.
Gastrin signaling mediated through cholecystokinin-2 receptor (CCK2R) and its downstream molecules is altered in pancreatic cancer. CCK2R antagonists, YF476 (netazepide) and JNJ-26070109, were tested systematically for their effect on pancreatic intraepithelial neoplasia (PanIN) progression to pancreatic ductal adenocarcinoma (PDAC) in Kras Topics: Adenocarcinoma; Animals; Benzodiazepinones; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Chemoprevention; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Proteins; Pancreatic Neoplasms; Phenylurea Compounds; Proto-Oncogene Proteins p21(ras); Quinoxalines; Receptor, Cholecystokinin B; Signal Transduction; Sulfonamides | 2019 |