yersiniabactin has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for yersiniabactin and Neoplasms
Article | Year |
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An Engineered Probiotic Platform for Cancer Epitope-Independent Targeted Radionuclide Therapy of Solid Tumors.
Targeted radionuclide therapy (TRT) is an emerging therapeutic modality for the treatment of various solid cancers. Current approaches rely on the presence of cancer-specific epitopes and receptors against which a radiolabeled ligand is systemically administered to specifically deliver cytotoxic doses of α and β particles to tumors. In this proof-of-concept study, tumor-colonizing Escherichia coli Nissle 1917 (EcN) is utilized to deliver a bacteria-specific radiopharmaceutical to solid tumors in a cancer-epitope independent manner. In this microbe-based pretargeted approach, the siderophore-mediated metal uptake pathway is leveraged to selectively concentrate copper radioisotopes, Topics: Animals; Cell Line, Tumor; Copper; Copper Radioisotopes; Escherichia coli; Mice; Neoplasms; Probiotics; Tumor Microenvironment | 2023 |