y 27632 has been researched along with Pulmonary Hypertension in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duggan, N; Hollingworth, G; Kosaka, T; Schuler, W; Shaw, D; Soldermann, N; Sprague, E; Thomas, M; van Eis, MJ; Vangrevelinghe, E; Waters, N | 1 |
| Adam, M; Aytekin, M; Baldus, S; Berghausen, E; Berlin, M; Dweik, RA; Friedrichs, K; Hazen, SL; Hennigs, JK; Heresi, GA; Kaltwasser, C; Klinke, A; Klose, H; Kubala, L; Lau, D; Manchanda, K; Mehrkens, D; Michaëlsson, E; Mollenhauer, M; Molz, S; Ravekes, T; Remane, L; Rosenkranz, S; Rudolph, TK; Rudolph, V; Schermuly, RT | 1 |
| Dhaliwal, R; Gosal, K; Ivanovska, J; Jankov, RP; Kantores, C; Lee, AH; Letarte, M; McNamara, PJ | 1 |
| Chen, CM; Chou, HC; Huang, LT; Yeh, TF | 1 |
| Chai, CY; Chen, IJ; Dai, ZK; Kao, LP; Wang, YY; Wu, BN; Wu, JR | 1 |
| Jiang, H; Lade, J; Shimoda, LA; Undem, C; Walker, J; Yun, X | 1 |
| Dempsie, Y; MacLean, MR; Mair, KM; Morecroft, I; Palmer, TM | 1 |
| Aaronson, PI; Becker, S; Connolly, M; Drndarski, S; Knock, GA; Noah, A; Pourmahram, GE; Shaifta, Y; Snetkov, VA; Ward, JP | 1 |
| Aoshima, D; Hori, M; Murata, T; Ozaki, H | 1 |
| Belcastro, R; Ivanovska, J; Jankov, RP; Kantores, C; Lau, M; McNamara, PJ; Tanswell, AK; Xu, EZ; Ziino, AJ | 1 |
| Chesler, NC; Tabima, DM | 1 |
| Badejo, AM; Casey, DB; Dhaliwal, JS; Fokin, A; Golwala, NH; Greco, AJ; Hyman, AL; Kadowitz, PJ; Murthy, SN; Nossaman, BD; Sikora, JL | 1 |
| Engelberts, D; Ivanovska, J; Jankov, RP; Kantores, C; Kavanagh, BP; McNamara, PJ; Xu, EZ | 1 |
| Asano, T; Seto, M | 1 |
| Seto, M | 1 |
| Bauer, N; Casanova, N; Gebb, S; McMurtry, I; Morio, Y; Nagaoka, T; Oka, M | 1 |
| Bauer, NR; Fagan, KA; Gebb, SA; Ivy, DD; McMurtry, IF; Morris, KG; Oka, M | 1 |
| Fagan, KA; Gebb, SA; McMurtry, IF; Morris, KG; Nagaoka, T; Oka, M; Shimokawa, H; Suzuki, T | 1 |
| Costello, CM; Howell, K; Hyvelin, JM; McLoughlin, P; Nichol, A; Preston, RJ | 1 |
| Barman, SA | 1 |
| Engelberts, D; Jankov, RP; Kantores, C; Kavanagh, BP; McNamara, PJ; Murthy, P; Teixeira, L; van Vliet, T | 1 |
| Gebb, SA; Homma, N; Karoor, V; McMurtry, IF; Morio, Y; Nagaoka, T; Oka, M; Ota, H | 1 |
| Ackerley, C; Engelberts, D; Jankov, RP; Kavanagh, BP; Kornecki, A; McCaul, C; McNamara, P; Post, M | 1 |
2 review(s) available for y 27632 and Pulmonary Hypertension
| Article | Year |
|---|---|
[Rho-kinase inhibitors].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Clinical Trials as Topic; Coronary Artery Disease; Drug Design; Glaucoma; Humans; Hypertension, Pulmonary; Mice; Molecular Targeted Therapy; Pyridines; Rats; rho-Associated Kinases; Vasospasm, Intracranial | 2011 |
[Development of Rho kinase inhibitors for pulmonary arterial hypertension].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Drug Design; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy; Pyridines; rho-Associated Kinases | 2012 |
21 other study(ies) available for y 27632 and Pulmonary Hypertension
| Article | Year |
|---|---|
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Topics: Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension, Pulmonary; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; Structure-Activity Relationship | 2014 |
Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase.
Topics: Adult; Amides; Animals; Cohort Studies; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Kaplan-Meier Estimate; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Peroxidase; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Vascular Remodeling; Vasoconstriction | 2018 |
Rho-kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation.
Topics: Amides; Animals; Animals, Newborn; Bleomycin; Chemokines; Down-Regulation; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Lung Injury; Macrophages; Neovascularization, Pathologic; Neutrophils; Pneumonia; Pulmonary Artery; Pyridines; Radiography; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Thrombospondin 1; Tumor Necrosis Factor-alpha; Vascular Resistance | 2014 |
Rho-kinase inhibitor Y-27632 attenuates pulmonary hypertension in hyperoxia-exposed newborn rats.
Topics: Amides; Animals; Animals, Newborn; Antihypertensive Agents; Blotting, Western; Disease Models, Animal; Female; Hyperoxia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Time Factors | 2013 |
Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery.
Topics: Amides; Animals; Ascorbic Acid; Endothelium, Vascular; Hypertension, Pulmonary; Hypoxia; Male; Nitric Oxide Synthase Type III; Piperidines; Pulmonary Artery; Pyridines; Rats; Sildenafil Citrate; Vascular Endothelial Growth Factors; Xanthines | 2015 |
Role of Rho kinase and Na+/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration.
Topics: Amides; Amiloride; Animals; Cation Transport Proteins; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Hypoxia; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Vascular Remodeling | 2016 |
Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.
Topics: Amides; Animals; Antihypertensive Agents; Cell Proliferation; Cricetinae; Cricetulus; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Hypertension, Pulmonary; Hypoxia; Mice; Mice, Inbred C57BL; Pulmonary Artery; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2A; rho-Associated Kinases; Serotonin Plasma Membrane Transport Proteins; Signal Transduction | 2008 |
Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization.
Topics: Active Transport, Cell Nucleus; Amides; Aminoquinolines; Animals; Bronchoconstriction; Calcium Signaling; Guanylate Cyclase; Hypertension, Pulmonary; Indoles; Male; Myocytes, Smooth Muscle; Myosin Light Chains; Phosphorylation; Protein Phosphatase 1; Pulmonary Artery; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; src-Family Kinases; Sulfonamides; Superoxides | 2009 |
Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension.
Topics: Actins; Amides; Animals; Cell Proliferation; Endothelin-1; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Phenotype; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Thiazines; Time Factors | 2009 |
Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Airway Remodeling; Amides; Animals; Animals, Newborn; Antihypertensive Agents; Becaplermin; Body Weight; Chronic Disease; Disease Models, Animal; DNA Replication; Dose-Response Relationship, Drug; Hyperoxia; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Muscle, Smooth, Vascular; Organ Size; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Pyridines; Rats; Receptor, Platelet-Derived Growth Factor beta; rho-Associated Kinases; Vascular Resistance | 2010 |
The effects of vasoactivity and hypoxic pulmonary hypertension on extralobar pulmonary artery biomechanics.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Biomechanical Phenomena; Cell Hypoxia; Hypertension, Pulmonary; Male; Mice; Muscle, Smooth, Vascular; Pulmonary Artery; Pyridines; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2010 |
Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Injections, Intravenous; Male; Monocrotaline; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Soluble Guanylyl Cyclase; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Age Factors; Aging; Amides; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endothelin-1; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Injections, Subcutaneous; Muscle, Smooth, Vascular; Myocardium; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Rats; Receptor, Endothelin A; rho-Associated Kinases; RNA Interference; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2010 |
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats.
Topics: Amides; Animals; Blood Pressure; Chromones; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Indoles; Injections, Intravenous; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Morpholines; Nifedipine; Potassium Chloride; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents | 2004 |
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.
Topics: Amides; Animals; Cardiomegaly; Enzyme Inhibitors; Hematocrit; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lung; Male; Mice; Mice, Inbred C57BL; Perfusion; Protein Serine-Threonine Kinases; Pulmonary Circulation; Pyridines; rho-Associated Kinases; Vasoconstriction; Ventricular Dysfunction, Right; Ventricular Function, Right | 2004 |
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Inhalation; Administration, Oral; Amides; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Male; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Treatment Outcome; Vasodilator Agents | 2005 |
Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.
Topics: Amides; Animals; Blood Pressure; Capillaries; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Intracellular Signaling Peptides and Proteins; Lung; Male; Neovascularization, Physiologic; Oxygen Consumption; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Vascular Endothelial Growth Factor A; Vascular Resistance; Vasoconstriction | 2005 |
Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.
Topics: Amides; Animals; Blotting, Western; Carbazoles; Endothelin-1; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle, Smooth, Vascular; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Species Specificity; Vasoconstriction | 2007 |
Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide.
Topics: Administration, Inhalation; Amides; Animals; Animals, Newborn; Bleomycin; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Macrophages; Nitric Oxide; Nitric Oxide Donors; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 2008 |
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.
Topics: Amides; Animals; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Peptides, Cyclic; Perfusion; Potassium Chloride; Pulmonary Artery; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Vasoconstriction | 2007 |
Vascular remodeling protects against ventilator-induced lung injury in the in vivo rat.
Topics: Amides; Animals; Cytokines; Disease Models, Animal; Echocardiography; Enzyme Inhibitors; Hypertension, Pulmonary; Hypoxia; Lung; Male; Microscopy, Electron; Pulmonary Circulation; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Respiratory Function Tests; Ventilators, Mechanical | 2008 |