y 27632 has been researched along with Muscle Contraction in 160 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (3.13) | 18.2507 |
| 2000's | 106 (66.25) | 29.6817 |
| 2010's | 46 (28.75) | 24.3611 |
| 2020's | 3 (1.88) | 2.80 |
| Authors | Studies |
|---|---|
| Inui, J; Ishizaki, T; Kawahara, T; Maekawa, M; Morishita, T; Narumiya, S; Ono, T; Satoh, H; Tamakawa, H; Uehata, M; Yamagami, K | 1 |
| Chess-Williams, R; Moro, C; Phelps, C | 1 |
| Bae, SI; Hwang, Y; Kim, JY; Lee, SH; Ok, SH; Sohn, JT; Subbarao, RB; Tak, S | 1 |
| Gaynullina, DK; Selivanova, EK; Shilova, LD; Shvetsova, AA; Tarasova, OS | 1 |
| Anjum, I; Denizalti, M; Durlu-Kandilci, NT; Kandilci, HB; Sahin-Erdemli, I | 1 |
| Buyukafsar, K; Cevik, OS; Koyuncu, DD; Sahin, L | 1 |
| Chess-Williams, R; Lim, I; Sellers, D | 1 |
| Bozkurt, TE; Denizalti, M; Durlu-Kandilci, NT; Sahin-Erdemli, I; Simsek, G | 1 |
| Domokos, D; Ducza, E; Gáspár, R | 1 |
| Hozaki, M; Matsumoto, T; Mizutani, E; Nakamura, M; Sugita, S | 1 |
| Chambers, JP; Hulls, CM; King, QM; Lentle, RG; Reynolds, GW | 1 |
| Rattan, S; Singh, J | 1 |
| Bai, G; Gui, Y; Li, D; Li, J; Liu, D; Walsh, MP; Wang, Z; Yuan, W; Zheng, XL | 1 |
| Al-Shboul, O; Mahavadi, S; Murthy, KS; Nalli, A | 1 |
| Hutchinson, JL; Norman, JE; Rajagopal, SP; Yuan, M | 1 |
| Hishinuma, S; Mita, M; Nakagawa, J; Shoji, M; Sutherland, C; Tanaka, H; Walsh, MP; Yanagihara, H | 1 |
| Carini, M; Cellai, I; Comeglio, P; Filippi, S; Gacci, M; Maggi, M; Maneschi, E; Morelli, A; Sarchielli, E; Vannelli, GB; Vignozzi, L | 1 |
| Chen, M; Hall, JE; Liu, X; Ma, L; Ying, Z | 1 |
| Fujii, M; Ishihara, H; Kagawa, Y; Koizumi, H; Nomura, S; Oka, F; Owada, Y; Sadahiro, H; Shinoyama, M; Shirao, S; Sugimoto, K; Suzuki, M; Tamechika, M; Yoneda, H | 1 |
| Al-Shboul, O; Mustafa, A | 1 |
| Alexandre, EC; Alves Junior, MJ; Antunes, E; Báu, FR; Calmasini, FB; Leiria, LO; Mónica, FZ; Silva, FH | 1 |
| Al-Qudah, M; Anderson, CD; Grider, JR; Kendig, DM; Mahavadi, S; Murthy, KS | 1 |
| Astarci, E; Aydinoglu, F; Balli, E; Ergurhan Kiroglu, O; Ogulener, N | 1 |
| Al-Shboul, O | 1 |
| Baik, J; Han, JY; Hong, JM; Kwon, SC; Oh, J; Ok, SH; Sohn, JT | 1 |
| Alon, R; Barzilai, S; Feigelson, SW; Golani, O; Klein, E; Morrell, S; Nourshargh, S; Roncato, F; Stoler-Barak, L; Yadav, SK; Zemel, A | 1 |
| Khin, PP; Sohn, UD; Zaw, TS | 1 |
| Ding, H; Huang, J; Isotani, E; Kamm, KE; Mizuno, Y; Stull, JT | 1 |
| Fry, CH; Roosen, A; Sui, G; Wu, C | 1 |
| Adamiak, A; Rechberger, T; Skorupski, P; Wróbel, A | 1 |
| Chrones, T; Preiksaitis, HG; Sims, SM | 1 |
| Benoit, M; Cuerrier, CM; Gobeil, F; Grandbois, M; Guillemette, G | 1 |
| Fitzgibbon, J; Morrison, JJ; O'Brien, M; Smith, TJ | 1 |
| Honjo, H; Ito, S; Kamiya, K; Kume, H; Makino, Y; Oguma, T; Shimokata, K; Shiraki, A | 1 |
| Arai, K; Kamai, T; Mizuno, T; Nakanishi, K; Yamanishi, T | 1 |
| Aikawa, K; Ishibashi, K; Kushida, N; Liu, F; Shiomi, H; Shishido, K; Takahashi, N; Yamaguchi, O; Yanagida, T | 1 |
| Park, SY; Sohn, UD; Song, HJ | 1 |
| Eto, M; Freitas, MR; Kirkbride, JA; Sassard, J; Schott, C; Stoclet, JC | 1 |
| Aoshima, D; Hori, M; Murata, T; Ozaki, H | 1 |
| Fujimoto, S; Ito, J; Mori-Kawabe, M; Tada, T; Tsushima, H | 1 |
| Joh, S; Kawaguchi, T; Kuji, A; Satoh, K | 1 |
| Jin, LM; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z | 1 |
| Denniss, SG; Jeffery, AJ; Rush, JW | 1 |
| Díaz, M; Gómez, T; González-Montelongo, MC; Marín, R; Marrero-Alonso, J | 1 |
| Chang, IH; Han, JH; Kim, HJ; Kim, W; Lee, MY; Lee, SY; Myung, SC | 1 |
| Cole, WC; Hollywood, M; McHale, N; Sergeant, G; Thornbury, K; Walsh, MP | 1 |
| Baeyens, N; Horman, S; Morel, N; Rider, M; Vertommen, D | 1 |
| Andersson, KE; Gratzke, C; Hartmann, AC; Hedlund, P; Hennenberg, M; Schlenker, B; Steib, CJ; Stief, CG; Strittmatter, F; Weinhold, P | 1 |
| Enouri, S; Johnson, R; Monteith, G | 1 |
| Bayguinov, O; Dwyer, L; Kim, H; Koh, SD; Marklew, A; Sanders, KM | 1 |
| Heaps, CL; Parker, JL; Robles, JC; Sturek, M | 1 |
| Hatano, Y; Ogawa, K; Tange, K; Tokinaga, Y; Uematsu, N | 1 |
| Maxwell, PJ; Rattan, S; Singh, J | 1 |
| Huh, YH; Kitazawa, T; Liao, JK; Zhou, Q | 1 |
| Cheng, YX; Lai, WY; Li, N; Li, X; Meng, Y; Niu, Y; Shen, B | 1 |
| Jiao, Y; Paré, PD; Raqeeb, A; Seow, CY; Syyong, HT | 1 |
| Hori, M; Kishi, H; Kobayashi, S; Mori, D; Murata, T; Ohama, T; Ozaki, H | 1 |
| Amobi, NI; Guillebaud, J; Smith, IC | 1 |
| Kajioka, S; Matsuda, M; Naito, S; Onimaru, M; Seki, N; Shahab, N; Takahashi-Yanaga, F | 1 |
| Kajioka, S; Naito, S; Seki, N; Shahab, N | 1 |
| Calzetta, L; Cazzola, M; Kanabar, V; Lauro, D; Matera, MG; Novelli, L; Page, CP; Rogliani, P | 1 |
| Balkanci, ZD; Bayrak, S; Erdem, A; Karabulut, I; Karaismailoğlu, S; Pehlivanoğlu, B | 1 |
| Al-Ghabkari, A; MacDonald, JA; Moffat, LD; Sutherland, C; Walsh, MP | 1 |
| Eddinger, TJ; Meehl, JT; Ratz, PH | 1 |
| Holmes, A; Johnson, JA; Prikosh, A; Wingard, CJ | 1 |
| Dai, YT; Lewis, RW; Mills, TM; Webb, RC | 1 |
| Jin, L; Linder, AE; Mills, TM; Webb, RC | 1 |
| Büyükafşar, K; Levent, A | 2 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Bing, W; Chacko, S; Chang, S; DiSanto, ME; Hypolite, JA; Rolf, L; Wein, AJ; Zderic, SA | 1 |
| Ghisdal, P; Morel, N; Vandenberg, G | 1 |
| Andersson, KE | 1 |
| Ayman, S; Gibson, A; McFadzean, I; Wallace, P; Wayman, CP | 1 |
| Hatano, Y; Ogawa, K; Tokinaga, Y; Yu, J | 1 |
| Ark, M; Büyükafşar, K; Levent, A | 1 |
| Cellek, S; Foxwell, NA; Kell, PD; Moncada, S; Ralph, DJ; Rees, RW | 1 |
| Adam, R | 1 |
| Bossemeyer, D; Breitenlechner, C; Engh, RA; Gassel, M; Hidaka, H; Huber, R; Kinzel, V | 1 |
| Brading, AF; Hashitani, H; Suzuki, H | 1 |
| Hyvelin, JM; McLoughlin, P; O'Connor, C | 1 |
| Arner, A; Bonnevier, J | 1 |
| Feil, R; Feil, S; Hofmann, F; Kleppisch, T; Klugbauer, N; Koller, A; Lee, TS; Moosmang, S; Schulla, V; Wegener, JW; Welling, A | 1 |
| Fujita, A; Hata, F; Hirayama, N; Kitayama, M; Kushida, M; Takeuchi, T | 1 |
| Amano, M; Kaibuchi, K; Kawabata, S; Nakayama, M; Takefuji, M | 1 |
| Albinsson, S; Hellstrand, P; Nordström, I | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Seki, N; Takahashi, R | 1 |
| Baird, AW; Collins, C; Quinn, T | 1 |
| Jin, L; Webb, RC; Ying, Z | 1 |
| Jiang, MJ; Tsai, MH | 1 |
| Chang Jeong, B; Hong, SK; Kim, BS; Kim, HH; Kwak, C | 1 |
| Cogolludo, A; Lodi, F; Moreno, L; Perez-Vizcaino, F; Tamargo, J | 1 |
| E Albo, M; Kuntz, S; Rajasekaran, M; Wilkes, N | 1 |
| Bae, YM; Cho, S; Choi, WH; Kim, B; Kim, J; Lee, CH; Lee, CK; Lee, YR | 1 |
| Teixeira, CE; Webb, RC; Ying, Z | 1 |
| Chiba, Y; Misawa, M; Sakai, H | 3 |
| Chiba, Y; Misawa, M; Sakai, H; Yu, Y | 1 |
| Sims, SM; Yaghi, A | 1 |
| Cho, S; Choi, WH; Choi, YJ; Kim, B; Kim, J; Kim, YS; Lee, CK; Lee, YR; Woo, NS | 1 |
| Mustafa, S; Oriowo, M | 1 |
| Orlando, KA; Pittman, RN; Stone, NL | 1 |
| Büyükafşar, K; Nacak, M; Sahan-Firat, S; Tiftik, RN | 1 |
| Gong, MC; Guo, Z; Pang, H; Post, SR; Su, W; Xie, Z | 1 |
| Bertagnolli, MM; Carothers, AM; Hunt, DH; Javid, SH; Moran, AE; Redston, M | 1 |
| Bivalacqua, TJ; Burnett, AL; Champion, HC; Jin, L; Lagoda, GA; Liu, T | 1 |
| Boterman, M; de Jong, AM; Hovens, I; Meurs, H; Nelemans, SA; Penninks, JM; Schaafsma, D; Zaagsma, J | 1 |
| Honjo, H; Ito, S; Kamiya, K; Kodama, I; Kume, H; Oguma, T; Shimokata, K; Takeda, N | 1 |
| Meurs, H; Nelemans, SA; Schaafsma, D; Zaagsma, J; Zuidhof, AB | 1 |
| Andersson, KE; Arner, A; Ekman, M | 1 |
| Ito, M; Kim, I; Kim, JI; Kim, SO; Kureishi, Y; Lim, DG; Nakano, T; Park, WH; Seok, Y | 1 |
| Koide, M; Nakayama, K; Obara, K; Uchino, M; Yamanaka, A | 1 |
| Baird, AW; Feighery, R; Quinn, T | 1 |
| Chae, SC; Jeon, SB; Jin, F; Jun, JE; Kim, IK; Kim, JI; Kim, SH; Park, WH; Suk, K | 1 |
| Amobi, NI; Chung, IP; Smith, IC | 1 |
| Aslan, G; Demir, O; Esen, AA; Gidener, S; Murat, N | 1 |
| Akça, T; Aydin, S; Büyükafşar, K; Nalan Tiftik, R; Sahan-Firat, S | 1 |
| Patel, CA; Rattan, S | 2 |
| D'Aprile, A; Fernandes, L; Goldie, R; Henry, P; McGuire, M; Self, G; Sew, T | 1 |
| Ito, S; Ito, Y; Kondo, M; Kume, H; Naruse, K; Oguma, T; Shimokata, K; Suki, B | 1 |
| Blough, ER; Desai, DH; Rice, KM; Wehner, P; Wright, GL | 1 |
| Kanaide, H; Naito, S; Nishimura, J; Seki, N; Takahashi, R; Tomoda, T; Yunoki, T | 1 |
| Azuma, YT; Hata, F; Nakajima, H; Takeuchi, T | 1 |
| Baek, I; Jeon, SB; Kim, IK; Kim, JI; Seok, YM; Shin, HM | 1 |
| de Godoy, MA; Katsuki, M; Patel, CA; Rattan, S; Regan, RF; Waldman, SA | 1 |
| Baarsma, HA; Dekkers, BG; Ens, KM; Frohwerk, E; Gosens, R; Halayko, AJ; McNeill, KD; Meurs, H; Nelemans, SA; Penninks, JM; Schaafsma, D; Sharma, P; Stelmack, GL; Zaagsma, J | 1 |
| Jin, L; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z | 1 |
| Ihara, E; MacDonald, JA; Moffat, L; Ostrander, J; Walsh, MP | 1 |
| Choritz, L; Meissner, S; Pfeiffer, N; Renieri, G; Rosenthal, R; Thieme, H | 1 |
| Chiba, Y; Hanazaki, M; Kohjitani, A; Misawa, M; Morita, K; Sakai, H; Yokoyama, M | 1 |
| Somlyo, AP | 1 |
| Fu, X; Gong, MC; Jia, T; Somlyo, AP; Somlyo, AV | 1 |
| Dobashi, K; Harada, T; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Yoshii, A | 1 |
| Feng, J; Isaka, N; Ito, M; Kureishi, Y; Nakano, T; Okinaka, T | 1 |
| Kaneko, H; Kato, M; Morikawa, A; Tabata, M; Takahashi, A; Tomomasa, T; Watanabe, T | 1 |
| Brautigan, DL; Eto, M; Kitazawa, T; Woodsome, TP | 1 |
| Mori, M; Tsushima, H | 1 |
| Hokazono, Y; Kobayashi, S; Kusuda, T; Miyake, T; Mizukami, Y; Mogami, K; Sato, M; Suzuki, S; Todoroki-Ikeda, N; Yamagata, H; Yamamoto, K | 1 |
| Dobashi, K; Harada, T; Iizuka, K; Mori, M; Murozono, T; Nakazawa, T; Shimizu, Y; Tsukagoshi, H; Yoshii, A | 1 |
| Ishizaki, T; Narumiya, S; Uehata, M | 1 |
| Nass, JU; Nuskovski, M; Pleyer, U; Strauss, O; Thieme, H; Wiederholt, M | 1 |
| Honda, Y; Honjo, M; Inatani, M; Kido, N; Narumiya, S; Sawamura, T; Tanihara, H; Yue, BY | 1 |
| Hirano, K; Kanaide, H; Nishimura, J; Setoguchi, H; Takahashi, S | 1 |
| Akahane, S; Anabuki, J; Hayakawa, K; Hori, M; Karaki, H; Ozaki, H | 1 |
| Amano, M; Araki, S; Feng, J; Hartshorne, DJ; Isaka, N; Ito, M; Kaibuchi, K; Kureishi, Y; Machida, H; Nakano, T | 1 |
| Brautigan, DL; Eto, M; Kitazawa, T; Mukai, H; Ono, Y; Yazawa, M | 1 |
| Cellek, S; Moncada, S; Ralph, DJ; Rees, RW; Royle, M | 1 |
| Jin, N; Li, L; Rhoades, RA; Swartz, DR; Wang, Z; Yancey, KW; Zhang, D | 1 |
| Brady, JD; Jezior, JR; McCammon, KA; Miner, AS; Ratz, PH; Rosenstein, DI | 1 |
| Chiba, Y; Misawa, M; Sakai, H; Takeyama, H | 1 |
| Spaan, JA; van der Meulen, ET; VanBavel, E | 1 |
| Azuma, M; Oka, T; Waki, M; Yoshida, Y | 1 |
| Ito, S; Ito, Y; Kume, H; Yamaki, K | 1 |
| Kernochan, LE; Melton, AC; Tam, SP; Tangkijvanich, P; Tran, BN; Yee, HF | 1 |
| Hayashi, H; Honjo, H; Ito, S; Katoh, H; Kodama, I; Kume, H; Yamaki, K | 1 |
| Fang, YI; Hashimoto, T; Momose, K; Nakano, Y; Ohata, H; Yamashita, M | 1 |
| Hishinuma, S; Mita, M; Saito, M; Walsh, MP; Yanagihara, H | 1 |
| Bao, J; Kohama, K; Liu, L; Nakamura, A; Oishi, K; Uchida, MK; Yamada, T | 1 |
4 review(s) available for y 27632 and Muscle Contraction
| Article | Year |
|---|---|
[Rho kinase--a new target for pharmacological treatment of an overactive bladder].
Topics: Amides; Animals; Enzyme Activation; Enzyme Inhibitors; Humans; Muscle Contraction; Muscle Relaxants, Central; Protein Serine-Threonine Kinases; Pyridines; Urinary Bladder; Urinary Bladder Diseases | 2008 |
Inhibition of the tonic contraction in the treatment of erectile dysfunction.
Topics: Adrenergic Agonists; Adult; Aged; Aging; Amides; Angiotensin II; Calcium Signaling; Cyclic AMP; Endothelin-1; Erectile Dysfunction; Forecasting; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Penis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoactive Intestinal Peptide | 2003 |
Erectile physiological and pathophysiological pathways involved in erectile dysfunction.
Topics: Amides; Animals; Diabetes Mellitus; Endothelin-1; Erectile Dysfunction; Humans; Hypothalamus; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Nitric Oxide; Norepinephrine; Penile Erection; Phosphorylation; Pyridines; Receptors, Endothelin; rho GTP-Binding Proteins | 2003 |
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angina Pectoris; Animals; Arteriosclerosis; Calcium; Enzyme Inhibitors; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases | 2004 |
156 other study(ies) available for y 27632 and Muscle Contraction
| Article | Year |
|---|---|
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.
Topics: Amides; Animals; Antihypertensive Agents; Calcium; Cell Adhesion; COS Cells; Enzyme Inhibitors; Guinea Pigs; Humans; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Recombinant Proteins; rho-Associated Kinases; Swine | 1997 |
The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.
Topics: Animals; Calcium; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Receptors, G-Protein-Coupled; rho-Associated Kinases; Swine; Urinary Bladder; Urothelium | 2023 |
Nitric oxide-mediated inhibition of phenylephrine-induced contraction in response to hypothermia is partially modulated by endothelial Rho-kinase.
Topics: Amides; Animals; Aorta; Endothelium, Vascular; Humans; Hypothermia, Induced; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Phenylephrine; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; rho-Associated Kinases; Signal Transduction; Vasoconstriction | 2020 |
Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Coronary Vessels; Disease Models, Animal; Female; Fetal Growth Retardation; Male; Mesenteric Arteries; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy; Pyridines; Rats, Wistar; rho-Associated Kinases | 2021 |
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis.
Topics: Amides; Animals; Calcium; Cystitis; Female; Gene Expression Regulation; Indoles; Lysophospholipids; Maleimides; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Urinary Bladder | 2017 |
Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle.
Topics: Amides; Animals; Atropine; Carbachol; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Nifedipine; Organ Culture Techniques; Pirenzepine; Pyridines; Ranidae; rho-Associated Kinases | 2018 |
Altered ureteral contractility with ageing: Role of the rho-kinase pathway.
Topics: Aging; Amides; Animals; Dose-Response Relationship, Drug; Female; Mice; Muscle Contraction; Phenylephrine; Pyridines; rho-Associated Kinases; Serotonin; Swine; Ureter | 2018 |
Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis.
Topics: Amides; Animals; Carbachol; Cholinergic Agonists; Cystitis, Interstitial; Enzyme Inhibitors; Heparin; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Protein Kinase C; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Signal Transduction; Urinary Bladder | 2018 |
RhoA and Rho-kinase inhibitors modulate cervical resistance: The possible role of RhoA/Rho-kinase signalling pathway in cervical ripening and contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cervical Ripening; Cervix Uteri; Female; In Vitro Techniques; Muscle Contraction; Pregnancy; Pyridines; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Simvastatin | 2019 |
Photoelasticity-based evaluation of cellular contractile force for phenotypic discrimination of vascular smooth muscle cells.
Topics: Actin Cytoskeleton; Amides; Animals; Cells, Cultured; Elasticity; Fluorescence; Marine Toxins; Microscopy, Fluorescence; Muscle Contraction; Muscle, Smooth, Vascular; Oxazoles; Phenotype; Pyridines; Swine | 2019 |
Pharmacological modulation of the spatiotemporal disposition of micromotions in the intact resting urinary bladder of the rabbit; their pattern is under both myogenic and autonomic control.
Topics: Adrenergic beta-Agonists; Amides; Animals; Carbachol; Carbenoxolone; Cholinergic Agonists; Isoproterenol; Muscle Contraction; Muscle Relaxants, Central; Pyridines; Rabbits; rho-Associated Kinases; Urinary Bladder | 2019 |
Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle.
Topics: Amides; Animals; Carcinogens; Enzyme Inhibitors; Fecal Incontinence; Indoles; Maleimides; Muscle Contraction; Muscle, Smooth; Naphthalenes; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Rectum; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2013 |
Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscle by distinct signaling pathways.
Topics: Adenosine Triphosphate; Amides; Animals; Dinucleoside Phosphates; Male; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Pyridines; Rats; Receptors, Purinergic P2Y; Signal Transduction; Stomach; Suramin; Vasoconstriction | 2013 |
Inhibition of MLC20 phosphorylation downstream of Ca2+ and RhoA: A novel mechanism involving phosphorylation of myosin phosphatase interacting protein (M-RIP) by PKG and stimulation of MLC phosphatase activity.
Topics: Adaptor Proteins, Signal Transducing; Amides; Animals; Calcium; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Muscle Contraction; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Phosphorylation; Pyridines; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; S-Nitrosoglutathione; Stomach | 2014 |
Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways.
Topics: Amides; Blotting, Western; Cell Line; Cells, Cultured; Female; Humans; Imidazoles; Infant, Newborn; Lipopolysaccharides; Muscle Cells; Muscle Contraction; Oxadiazoles; Pregnancy; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Uterine Contraction; Uterus | 2014 |
Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation.
Topics: Amides; Animals; Arteries; Calcium; Genistein; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphorylation; Potassium; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Tyrosine; Vanadates | 2013 |
Tadalafil effect on metabolic syndrome-associated bladder alterations: an experimental study in a rabbit model.
Topics: Amides; Animals; Carbolines; Diet, High-Fat; Enzyme Inhibitors; Male; Metabolic Syndrome; Muscle Contraction; Muscle, Smooth; Pyridines; Rabbits; rho-Associated Kinases; Signal Transduction; Tadalafil; Up-Regulation; Urinary Bladder Diseases; Urological Agents | 2014 |
Dual regulation of tumor necrosis factor-α on myosin light chain phosphorylation in vascular smooth muscle.
Topics: Amides; Animals; Aorta; Cell Line; Cells, Cultured; Humans; I-kappa B Kinase; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts.
Topics: Amides; Animals; Antihypertensive Agents; Basilar Artery; beta-Cyclodextrins; Carotid Artery, Internal; Cholesterol; Dietary Fats; Male; Membrane Microdomains; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Sphingosine; Vasospasm, Intracranial | 2015 |
Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach.
Topics: Amides; Animals; Cells, Cultured; Hydrogen Peroxide; Male; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Oxidative Stress; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Stomach | 2015 |
Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency.
Topics: Adenosine Triphosphate; Amides; Animals; Carbachol; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Prostate; Pyridines; Rats; rho-Associated Kinases; Signal Transduction | 2015 |
Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carbachol; Cholinergic Neurons; Colon; Enzyme Inhibitors; In Vitro Techniques; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Myosin-Light-Chain Kinase; Naphthalimides; Peptide Fragments; Pyridines; Rats, Sprague-Dawley; Receptor, Muscarinic M3; rho-Associated Kinases | 2014 |
Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Ethanol; Lung; Male; Mice; Microscopy, Electron; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2015 |
The role of the RhoA/ROCK pathway in gender-dependent differences in gastric smooth muscle contraction.
Topics: Amides; Animals; Female; Gene Expression Regulation; Male; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Sex Factors; Stomach | 2016 |
Dexmedetomidine-Induced Contraction Involves CPI-17 Phosphorylation in Isolated Rat Aortas.
Topics: Adrenergic alpha-2 Receptor Agonists; Amides; Animals; Aorta; Benzophenanthridines; Calcium; Cells, Cultured; Dexmedetomidine; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Yohimbine | 2016 |
Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments.
Topics: Actin Cytoskeleton; Actins; Amides; Antigens, CD; Cadherins; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heterocyclic Compounds, 4 or More Rings; Humans; Interleukin-1beta; Leukocytes; Muscle Contraction; Myosin Type II; Neutrophils; Pyridines; rho-Associated Kinases; T-Lymphocytes; Time-Lapse Imaging; Transendothelial and Transepithelial Migration | 2017 |
Signal Transduction Underlying the Inhibitory Mechanism of Fluoxetine on Electrical Field Stimulation Response in Rat Ileal Smooth Muscle.
Topics: 4-Aminopyridine; Amides; Animals; Atropine; Azepines; Benzophenanthridines; Bicuculline; Calcimycin; Drug Interactions; Electric Stimulation; Estrenes; Fluoxetine; Glyburide; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Ondansetron; Pyridines; Pyrrolidinones; Rats; Signal Transduction; Sulfonamides; Tetraethylammonium | 2017 |
Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo.
Topics: Amides; Animals; Calcium; Calcium Signaling; Calmodulin; Carbachol; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Mice; Mice, Transgenic; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Naphthalenes; Phosphoproteins; Phosphorylation; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Urinary Bladder | 2008 |
Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.
Topics: Amides; Animals; Calcium Signaling; Carbachol; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Phenylephrine; Protein Kinase C; Pyridines; Receptor Cross-Talk; Receptors, Adrenergic; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2009 |
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Benzophenanthridines; Calcium; Electric Stimulation; Esophageal Sphincter, Lower; Humans; In Vitro Techniques; Muscle Contraction; Naphthalenes; Protein Kinase C; Pyridines; rhoA GTP-Binding Protein | 2008 |
Real-time monitoring of angiotensin II-induced contractile response and cytoskeleton remodeling in individual cells by atomic force microscopy.
Topics: Actins; Amides; Angiotensin II; Azepines; Cell Line; Cell Size; Cytological Techniques; Cytoskeleton; Elastic Modulus; Heterocyclic Compounds, 4 or More Rings; Humans; Kidney; Microscopy, Atomic Force; Microscopy, Confocal; Muscle Contraction; Pyridines; Receptor, Angiotensin, Type 1 | 2009 |
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin.
Topics: Amides; Cell Culture Techniques; Cell Line; Collagen; Female; Humans; Indomethacin; Muscle Contraction; Myocytes, Smooth Muscle; Myometrium; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thrombin; Tumor Necrosis Factor-alpha | 2009 |
Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Diltiazem; Dinoprost; Dioxanes; Enzyme Inhibitors; Estrenes; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Norbornanes; Pyridines; Pyrrolidinones; Receptors, Thromboxane A2, Prostaglandin H2; rho-Associated Kinases; Signal Transduction; Thiocarbamates; Thiones; Trachea; Type C Phospholipases; Vasoconstrictor Agents; Verapamil | 2009 |
Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder.
Topics: Amides; Animals; Blotting, Western; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Swine; Urinary Bladder; Urothelium | 2009 |
Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat.
Topics: Amides; Animals; Blotting, Western; Carbachol; Electric Stimulation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; In Vitro Techniques; Male; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Organ Size; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho GTP-Binding Proteins; rho-Associated Kinases; Urinary Bladder; Urinary Bladder Neck Obstruction | 2009 |
Participation of Rho-associated kinase in electrical stimulated and acetylcholine-induced contraction of feline esophageal smooth muscle.
Topics: Acetylcholine; Amides; Animals; Blotting, Western; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Esophagus; Female; Gene Expression Regulation, Enzymologic; Male; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Protein Isoforms; Pyridines; rho-Associated Kinases; Signal Transduction; Time Factors | 2009 |
Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle.
Topics: Amides; Animals; Calcium; Calcium Chloride; Disease Models, Animal; Hypertension; Male; Mesenteric Arteries; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Pyridines; Rats; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction | 2009 |
Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension.
Topics: Actins; Amides; Animals; Cell Proliferation; Endothelin-1; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Nicardipine; Phenotype; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Thiazines; Time Factors | 2009 |
Role of Rho/Rho-kinase and NO/cGMP signaling pathways in vascular function prior to atherosclerosis.
Topics: Amides; Animals; Apolipoproteins E; Atherosclerosis; Cyclic GMP; Endothelium, Vascular; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Nitric Oxide; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2009 |
Features of distinct contractions induced with a high and a low concentration of KCl, noradrenaline, and histamine in swine lingual artery.
Topics: Amides; Animals; Arteries; Boron Compounds; Calcium; Dose-Response Relationship, Drug; Endothelium, Vascular; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Potassium Chloride; Pyridines; rho-Associated Kinases; Signal Transduction; Swine; Tongue; Vasoconstrictor Agents | 2010 |
Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Penis; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Species Specificity; Up-Regulation | 2010 |
RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction.
Topics: Amides; Animals; Carotid Artery, Common; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypertension; In Vitro Techniques; Muscle Contraction; Muscle Proteins; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Peroxides; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Thromboxane; rho-Associated Kinases; Signal Transduction | 2010 |
Androgens induce nongenomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17.
Topics: Amides; Androgens; Animals; Benzophenanthridines; Blotting, Western; Calcium; Colon; Cycloheximide; Dactinomycin; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Flutamide; In Vitro Techniques; Male; Mice; Models, Biological; Models, Theoretical; Muscle Contraction; Muscle, Smooth; Phosphorylation; Protein Kinase C; Pyridines; Receptors, Androgen; rho-Associated Kinases; Signal Transduction; Testosterone | 2010 |
Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Amides; Animals; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Verapamil; Vitamin E | 2010 |
Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Electric Stimulation; Male; Muscle Contraction; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphorylation; Potassium Chloride; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Urethra | 2011 |
Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery.
Topics: Amides; Animals; Antihypertensive Agents; Aorta; Carrier Proteins; Ionomycin; Male; Mesenteric Arteries; Microfilament Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phosphoproteins; Potassium Chloride; Protein Binding; Protein Kinase C; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; RNA, Small Interfering; Sodium-Hydrogen Exchangers | 2010 |
Thromboxane A2 induces contraction of human prostate smooth muscle by Rho kinase- and calmodulin-dependent mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Amides; Calcium; Calmodulin; Enzyme Inhibitors; Humans; Immunoenzyme Techniques; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Prostate; Pyridines; Receptors, Thromboxane A2, Prostaglandin H2; rho-Associated Kinases; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents | 2011 |
Characteristics of myogenic reactivity in isolated rat mesenteric veins.
Topics: Amides; Animals; Benzophenanthridines; Calcium; Calcium Channels, L-Type; Compliance; Endothelin-1; Endothelium, Vascular; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Synthase Type III; Nitroarginine; Norepinephrine; Pressure; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2011 |
Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.
Topics: Amides; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Carbachol; Cell Membrane; Colon; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Mice; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Pyridines; rho-Associated Kinases | 2011 |
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Calcium; Collateral Circulation; Coronary Vessels; Endothelin-1; Enzyme Inhibitors; Female; Muscle Contraction; Naphthalenes; Phorbol 12,13-Dibutyrate; Physical Conditioning, Animal; Protein Kinase C; Pyridines; rho-Associated Kinases; Swine; Vasodilator Agents | 2011 |
Sevoflurane inhibits angiotensin II-induced Rho kinase-mediated contraction of vascular smooth muscle from spontaneously hypertensive rat.
Topics: Amides; Anesthetics, Inhalation; Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Calcium Signaling; Enzyme Inhibitors; In Vitro Techniques; Isometric Contraction; Male; Methyl Ethers; Muscle Contraction; Muscle, Smooth, Vascular; Protein Transport; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Sevoflurane | 2011 |
Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells.
Topics: ADP Ribose Transferases; Amides; Anal Canal; Botulinum Toxins; Cells, Cultured; Fluorescent Antibody Technique; Humans; Muscle Contraction; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Naphthalenes; Phorbol 12,13-Dibutyrate; Protein Kinase C-alpha; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2011 |
ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery.
Topics: Amides; Animals; Cattle; Constriction, Pathologic; Enzyme Inhibitors; Mesenteric Arteries; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Organ Culture Techniques; Phosphorylation; Pyridines; Rabbits; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein | 2011 |
[Activation of Rho-kinase pathway is involved in angiotensin II-induced contraction of human airway smooth muscle cells].
Topics: Amides; Angiotensin II; Asthma; Biphenyl Compounds; Bronchi; Humans; Irbesartan; Muscle Contraction; Muscle, Smooth; Primary Cell Culture; Pyridines; rho-Associated Kinases; Signal Transduction; Tetrazoles | 2011 |
Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?
Topics: Amides; Animals; Asthma; Azepines; Calcium; Imidazoles; In Vitro Techniques; Molecular Targeted Therapy; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Kinase; Naphthalenes; Phosphorylation; Pyridines; rho-Associated Kinases; Sheep; Signal Transduction; Trachea | 2012 |
Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agonists; Guanosine Triphosphate; Intestines; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Phosphoproteins; Phosphorylation; Potassium; Protein Kinase C; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2011 |
Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Amides; Apamin; Calcium Channel Agonists; Calcium Channels, L-Type; Humans; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Norepinephrine; Peptides; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Purinergic P2X Receptor Agonists; Pyridines; Pyrophosphatases; Pyrroles; Receptors, Purinergic P2X; rho-Associated Kinases; Suramin; Vas Deferens | 2012 |
Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Enzyme Inhibitors; Guinea Pigs; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Pyridines; rho-Associated Kinases; Signal Transduction; Urinary Bladder Neck Obstruction | 2012 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Pyridines; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2012 |
High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway.
Topics: Acetylcholine; Amides; Bradykinin; Bronchi; Calcium Signaling; Cells, Cultured; Enzyme Activation; Female; Glucose; Histamine; Humans; Hyperglycemia; Imidazoles; In Vitro Techniques; Male; Mannitol; Middle Aged; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Osmolar Concentration; Oxadiazoles; Phosphorylation; Protein Processing, Post-Translational; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases | 2012 |
The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels.
Topics: Amides; Animals; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Hypercholesterolemia; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Urinary Bladder | 2012 |
Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Arteries; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Death-Associated Protein Kinases; Immunoprecipitation; Indoles; Male; Maleimides; Microcystins; Muscle Contraction; Muscle, Smooth, Vascular; Octoxynol; Phosphorylation; Protein Binding; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; rho-Associated Kinases; Staurosporine; Threonine; Time Factors | 2013 |
RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Stomach; Urinary Bladder | 2002 |
Improved erectile function after Rho-kinase inhibition in a rat castrate model of erectile dysfunction.
Topics: Amides; Animals; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Erectile Dysfunction; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Orchiectomy; Penis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Testosterone; Time Factors | 2003 |
[Inhibition of tonic contraction of smooth muscle: a new approach to achieve erection dysfunction].
Topics: Amides; Animals; Disease Models, Animal; Erectile Dysfunction; Humans; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Penile Erection; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein | 2002 |
Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Carbachol; Electric Stimulation; Enzyme Inhibitors; Female; Gastric Fundus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2003 |
Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle.
Topics: Adrenergic alpha-Agonists; Amides; Animals; Calcium; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Penis; Phenylephrine; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases | 2003 |
Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase.
Topics: Amides; Animals; Enzyme Inhibitors; Hypertrophy; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoenzymes; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocytes, Smooth Muscle; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphorylation; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; RNA, Messenger; Urinary Bladder; Urinary Bladder Neck Obstruction | 2003 |
Rho-dependent kinase is involved in agonist-activated calcium entry in rat arteries.
Topics: Aluminum Compounds; Amides; Animals; Aorta; Barium; Calcium; Calcium Channel Blockers; Calcium Signaling; Enzyme Inhibitors; Fluorides; GTP-Binding Proteins; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Male; Mesenteric Arteries; Mitochondria; Muscle Contraction; Muscle, Smooth, Vascular; Nimodipine; Norepinephrine; Potassium Channel Blockers; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Vasoconstrictor Agents | 2003 |
Receptor-independent activation of Rho-kinase-mediated calcium sensitisation in smooth muscle.
Topics: Amides; Anal Canal; Animals; Blotting, Western; Calcium; Carbachol; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; rho-Associated Kinases; Thapsigargin | 2003 |
Sevoflurane inhibits guanosine 5'-[gamma-thio]triphosphate-stimulated, Rho/Rho-kinase-mediated contraction of isolated rat aortic smooth muscle.
Topics: Amides; Anesthetics, Inhalation; Animals; Aorta, Thoracic; Cell Membrane; Cytosol; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Methyl Ethers; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; Sevoflurane; Signal Transduction | 2003 |
Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanethidine; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Vas Deferens | 2003 |
Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells.
Topics: Adrenergic alpha-Agonists; Amides; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Humans; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Norepinephrine; Phenylephrine; Prostate; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2003 |
Rho-kinase inhibitors: potential therapeutics for benign prostate hyperplasia.
Topics: Amides; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Prostatic Hyperplasia; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2003 |
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Amino Acid Sequence; Animals; Binding Sites; Cattle; Cell Adhesion; Crystallography, X-Ray; Cyclic AMP-Dependent Protein Kinases; Electrons; Enzyme Inhibitors; Escherichia coli; Glycine; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid | 2003 |
Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder.
Topics: Action Potentials; Amides; Animals; Apamin; Boron Compounds; Calcium; Calcium Signaling; Carbachol; Charybdotoxin; Colforsin; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Female; Fura-2; Guinea Pigs; Isotonic Contraction; Male; Mechanotransduction, Cellular; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyridines; Transducers; Urinary Bladder | 2004 |
Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway.
Topics: Amides; Animals; Aorta, Thoracic; Enzyme Activation; Enzyme Inhibitors; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Models, Biological; Muscle Contraction; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation | 2004 |
Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca²⁺ sensitization in smooth muscle.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amides; Animals; Bacterial Toxins; Blood Vessels; Calcium; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Escin; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intestine, Small; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Permeability; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2004 |
An essential role of Cav1.2 L-type calcium channel for urinary bladder function.
Topics: Amides; Animals; Calcium; Calcium Channels, L-Type; Carbachol; Enzyme Inhibitors; Estrenes; Intracellular Signaling Peptides and Proteins; Ion Channel Gating; Ion Transport; Isradipine; Mice; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Pyridines; Pyrrolidinones; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Thapsigargin; Urinary Bladder; Urination Disorders | 2004 |
Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.
Topics: ADP Ribose Transferases; Alkaloids; Amides; Animals; Bacterial Toxins; Benzophenanthridines; Botulinum Toxins; Calcium; Carbachol; Cell Membrane Permeability; Colon, Ascending; Colon, Descending; Escin; Guanosine Triphosphate; Hemolysin Proteins; Intracellular Signaling Peptides and Proteins; Japan; Male; Muscle Contraction; Myocytes, Smooth Muscle; Peptide Fragments; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic; rho-Associated Kinases; Tritium; Type C Phospholipases | 2004 |
Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization.
Topics: Actin Depolymerizing Factors; Actins; Amides; Animals; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cofilin 2; Depsipeptides; Desmin; Electrophoresis, Gel, Two-Dimensional; Female; Intracellular Signaling Peptides and Proteins; Mice; Microfilament Proteins; Microscopy, Fluorescence; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth; Peptides, Cyclic; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Serum Response Factor; Time Factors; Tropomyosin | 2004 |
Ca2+ sensitization in contraction of human bladder smooth muscle.
Topics: Aged; Amides; Calcium; Female; Humans; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Urinary Bladder | 2004 |
Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.
Topics: Amides; Animals; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Neurokinin A; Pyridines; Rats; Rats, Wistar; Substance P; Urinary Bladder | 2004 |
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta.
Topics: Amides; Animals; Aorta; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2004 |
Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Butadienes; Calcium; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Genistein; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Nitriles; Phenylephrine; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
Involvement of Rho-kinase in the contractile mechanism of human ureteral smooth muscle.
Topics: Adult; Amides; Blotting, Western; Humans; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Myocytes, Smooth Muscle; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Ureter | 2005 |
Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Aging; Amides; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelium, Vascular; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Kinase C; Pulmonary Artery; Pyridines; rhoA GTP-Binding Protein; Signal Transduction; Swine; Thromboxane A2 | 2005 |
Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats.
Topics: Amides; Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Urinary Bladder; Urinary Incontinence; Urodynamics | 2005 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hypertension; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilator Agents; Verapamil | 2005 |
Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Blood Pressure; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitroprusside; Penis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2005 |
Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.
Topics: Amides; Animals; Atropine; Blotting, Western; Bronchi; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Transport; Pyridines; Rats; Rats, Wistar; Receptor, Endothelin A; rhoA GTP-Binding Protein; Time Factors | 2005 |
Effects of repeated antigen exposure on endothelin-1-induced bronchial smooth muscle contraction and activation of RhoA in sensitized rats.
Topics: Amides; Animals; Antigens; Bronchi; Bronchial Hyperreactivity; Calcium; Dose-Response Relationship, Drug; Endothelin-1; Male; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Time Factors | 2005 |
Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Calcium; Calcium Signaling; Cell Nucleus; Cyclosporine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Lung Diseases; Male; Muscle Contraction; Muscle, Smooth; NFATC Transcription Factors; Organ Culture Techniques; Phenylephrine; Protein Isoforms; Pulmonary Artery; Pyridines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2005 |
Cdc42 contributes to phorbol ester-induced Ca2+-independent contraction of pulmonary artery smooth muscle.
Topics: Amides; Animals; Calcium; cdc42 GTP-Binding Protein; Immunoblotting; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phorbol Esters; Protein Kinase C; Protein Transport; Pulmonary Artery; Pyridines; Signal Transduction; Swine; Verapamil | 2005 |
Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Capsaicin; Cold Temperature; Enzyme Activation; Enzyme Inhibitors; Gastric Fundus; Gene Expression; Genistein; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger; TRPM Cation Channels | 2005 |
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Caspase Inhibitors; Caspases; Cell Membrane; Chlorocebus aethiops; COS Cells; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Heterocyclic Compounds, 4 or More Rings; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Myosins; PC12 Cells; Phagocytosis; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Rats; rho-Associated Kinases; RNA, Small Interfering; Thiazoles; Thiazolidines | 2006 |
Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli.
Topics: Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Gallbladder; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isoenzymes; Muscle Contraction; Muscle, Smooth; Neurokinin A; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serotonin; Sheep; Signal Transduction | 2005 |
Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucose; Immunoblotting; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation | 2006 |
Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.
Topics: Actin Depolymerizing Factors; Actomyosin; Adenomatous Polyposis Coli Protein; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Cadherins; Calcium; Cardiac Myosins; Celecoxib; Cell Adhesion; Egtazic Acid; Enterocytes; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, G12-G13; Intestinal Mucosa; Intestine, Small; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Muscle Contraction; Muscle Relaxants, Central; Myosin Light Chains; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Quinazolines; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Sulfonamides; Tyrphostins; Up-Regulation | 2006 |
Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction.
Topics: Aging; Amides; Amino Acid Substitution; Animals; Dependovirus; Erectile Dysfunction; Genetic Therapy; Genetic Vectors; Intracellular Signaling Peptides and Proteins; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth, Vascular; Mutation, Missense; Myosin-Light-Chain Phosphatase; Penis; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation | 2006 |
Differential Rho-kinase dependency of full and partial muscarinic receptor agonists in airway smooth muscle contraction.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Alkylation; Amides; Animals; Bronchoconstrictor Agents; Calcium; Cattle; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Organ Culture Techniques; Pilocarpine; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; rho-Associated Kinases; Trachea | 2006 |
Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle.
Topics: Adrenergic beta-Agonists; Amides; Animals; Asthma; Bucladesine; Calcium; Calcium Channel Blockers; Colforsin; Cyclic AMP Receptor Protein; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Fura-2; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoproterenol; Male; Maleimides; Marine Toxins; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Oxazoles; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Trachea | 2006 |
Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations.
Topics: Amides; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Ovalbumin; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Time Factors; Trachea | 2006 |
Developmental regulation of nerve and receptor mediated contractions of mammalian urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Age Factors; Amides; Animals; Animals, Newborn; Carbachol; Cholinergic Agonists; Cholinergic Fibers; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Stimulation; Female; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Nifedipine; Pyridines; Receptors, Muscarinic; Scopolamine; Tetrodotoxin; Urinary Bladder; Vasodilator Agents | 2006 |
Heat shock-induced augmentation of vascular contractility is independent of rho-kinase.
Topics: Actins; Amides; Animals; Aorta, Thoracic; Blotting, Western; Hot Temperature; HSP72 Heat-Shock Proteins; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myosin Light Chains; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Shock; Vasoconstrictor Agents | 2006 |
Stretch-induced triphosphorylation of myosin light chain and myogenic tone in canine basilar artery.
Topics: Amides; Animals; Azepines; Basilar Artery; Calcium; Calcium Channel Blockers; Dogs; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Naphthalenes; Nicardipine; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Reflex, Stretch; rho-Associated Kinases; Time Factors | 2006 |
Role of Rho-kinase in guinea-pig gallbladder smooth muscle contraction.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Carbachol; Cholecystokinin; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gallbladder; Guinea Pigs; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Thapsigargin | 2006 |
A role for Rho kinase in vascular contraction evoked by sodium fluoride.
Topics: Amides; Animals; Aorta; Carrier Proteins; Enzyme Activation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Sodium Fluoride; Vasoconstriction | 2006 |
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Azepines; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Norepinephrine; Potassium; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; rho-Associated Kinases; Vas Deferens | 2006 |
Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction.
Topics: Adrenergic alpha-Antagonists; Aged; Amides; Dose-Response Relationship, Drug; Doxazosin; Erectile Dysfunction; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Penis; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Urinary Bladder Neck Obstruction | 2006 |
Contribution of Rho-kinase in human gallbladder contractions.
Topics: Aged; Amides; Blotting, Western; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Female; Gallbladder; Histamine; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle Contraction; Neurokinin A; Peptide Fragments; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Serotonin | 2006 |
Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle.
Topics: Amides; Animals; Carrier Proteins; Enzyme Inhibitors; Immunoblotting; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Muscle Contraction; Muscle Proteins; Muscle Tonus; Muscle, Smooth; Phosphoprotein Phosphatases; Phosphoproteins; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA | 2006 |
A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release.
Topics: Amides; Animals; Carbachol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred CBA; Muscle Contraction; Muscle, Smooth, Vascular; Neurotransmitter Agents; Parasympathetic Nervous System; Parasympathomimetics; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Trachea | 2006 |
Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cations; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gadolinium; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Ion Channels; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrobenzenes; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; rho-Associated Kinases; Simvastatin; Stress, Mechanical; Sulfonamides; Trachea | 2006 |
Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle.
Topics: Amides; Animals; Bronchi; Endothelin-1; Enzyme Inhibitors; Male; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin Light Chains; Phosphoproteins; Phosphorylation; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2007 |
Aging alters mechanical and contractile properties of the Fisher 344/Nnia X Norway/Binia rat aorta.
Topics: Aging; Amides; Animals; Aorta; Biomechanical Phenomena; Endothelium, Vascular; Enzyme Inhibitors; Male; Models, Animal; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Heavy Chains; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Potassium; Pyridines; Rats; Rats, Inbred BN; Rats, Inbred F344 | 2007 |
RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Prostate; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Type C Phospholipases | 2007 |
A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon.
Topics: Alkaloids; Amides; Animals; Benzophenanthridines; Calcium; Carbachol; Carcinogens; Cholinergic Agonists; Colon; Dose-Response Relationship, Drug; Guanosine Triphosphate; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Receptors, Muscarinic | 2007 |
Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK.
Topics: ADP Ribose Transferases; Amides; Anal Canal; Animals; Botulinum Toxins; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Guanine Nucleotide Dissociation Inhibitors; Indoles; Intracellular Signaling Peptides and Proteins; Male; Maleimides; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myocytes, Smooth Muscle; Myosin Light Chains; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Rectum; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2007 |
Heat shock augments myosin phosphatase target-subunit phosphorylation.
Topics: Amides; Amino Acid Sequence; Animals; Azepines; Carrier Proteins; Heat-Shock Response; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Naphthalenes; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Threonine | 2007 |
H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter.
Topics: Amides; Anal Canal; Animals; Blotting, Western; Cells, Cultured; DNA; Electrophoresis, Agar Gel; Enzyme Inhibitors; Gene Expression; Genes, ras; Genotype; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Microscopy, Phase-Contrast; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases | 2007 |
Insulin increases the expression of contractile phenotypic markers in airway smooth muscle.
Topics: Amides; Animals; Calcium-Binding Proteins; Calponins; Cattle; Cell Shape; Cells, Cultured; Chromones; Contractile Proteins; Hypoglycemic Agents; Insulin; Intracellular Signaling Peptides and Proteins; Microfilament Proteins; Morpholines; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Organ Culture Techniques; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, IGF Type 1; Receptor, IGF Type 2; Receptor, Insulin; rho-Associated Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; Smooth Muscle Myosins; Time Factors; Trachea; Transcription, Genetic | 2007 |
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Blotting, Western; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Guanine Nucleotide Dissociation Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Urethra; Urinary Bladder | 2007 |
Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.
Topics: Amides; Animals; Apoptosis Regulatory Proteins; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Death-Associated Protein Kinases; Ileum; Indoles; Maleimides; Microcystins; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoproteins; Protein Kinase C; Protein Phosphatase 1; Pyridines; Rats | 2007 |
Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork.
Topics: Amides; Animals; Blotting, Western; Calcium; Cattle; Cell Culture Techniques; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; rho-Associated Kinases; rhoA GTP-Binding Protein; Trabecular Meshwork | 2008 |
Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Amides; Animals; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Propofol; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2008 |
Signal transduction. Rhomantic interludes raise blood pressure.
Topics: Amides; Blood Pressure; Calcium; Enzyme Inhibitors; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; ras Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 1997 |
The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Arachidonic Acid; Calcium; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Models, Biological; Muscle Contraction; Muscle, Smooth, Vascular; Myosin Light Chains; Octoxynol; Permeability; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases | 1998 |
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Animals; Bronchi; Calcium; Carbachol; Cholinergic Agents; Detergents; Dose-Response Relationship, Drug; Endothelin-1; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Octoxynol; Oxazoles; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Signal Transduction; Trachea; Type C Phospholipases | 1999 |
Regulation of Ca2+-independent smooth muscle contraction by alternative staurosporine-sensitive kinase.
Topics: Amides; Animals; Enzyme Inhibitors; Male; Microcystins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Peptides, Cyclic; Phosphorylation; Pyridines; Rabbits; Rho Factor; Staurosporine; Vasoconstrictor Agents | 1999 |
Y-27632 inhibits gastric motility in conscious rats.
Topics: Amides; Animals; Enzyme Inhibitors; Gastrointestinal Motility; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2000 |
Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility.
Topics: Amides; Animals; Cell Membrane Permeability; Enzyme Inhibitors; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phenylephrine; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Type C Phospholipases | 2000 |
Activation of Rho signaling contributes to lysophosphatidic acid-induced contraction of intact ileal smooth muscle of guinea-pig.
Topics: Acetylcholine; Amides; Animals; Guinea Pigs; Ileum; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vasodilator Agents | 2000 |
Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase.
Topics: Amides; Animals; Calcium; Coronary Vessels; Cytosol; Enzyme Inhibitors; Guanosine Triphosphate; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylcholine; Potassium; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sphingosine; Swine | 2000 |
Evaluation of Y-27632, a rho-kinase inhibitor, as a bronchodilator in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Amides; Animals; Blood Pressure; Bronchodilator Agents; Enzyme Inhibitors; Guinea Pigs; Intracellular Signaling Peptides and Proteins; Lung; Male; Muscle Contraction; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2000 |
Use and properties of ROCK-specific inhibitor Y-27632.
Topics: 3T3 Cells; Adenosine Triphosphate; Amides; Animals; Antihypertensive Agents; Binding, Competitive; Cell Size; Enzyme Inhibitors; Focal Adhesions; Intracellular Signaling Peptides and Proteins; Mice; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Neurites; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Stress Fibers | 2000 |
Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A.
Topics: Amides; Animals; Blotting, Western; Calcium; Cattle; Cells, Cultured; Chelating Agents; Ciliary Body; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Phorbols; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Tetradecanoylphorbol Acetate; Trabecular Meshwork | 2000 |
Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
Topics: Actins; Amides; Animals; Anterior Chamber; Aqueous Humor; Blotting, Western; Cells, Cultured; Ciliary Body; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Intracellular Signaling Peptides and Proteins; Intraocular Pressure; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pupil; Pyridines; Rabbits; rho-Associated Kinases; Trabecular Meshwork; Vinculin | 2001 |
Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway.
Topics: Amides; Animals; Calcium; Carbachol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Leukotriene C4; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Swine; Trachea; Type C Phospholipases | 2001 |
Muscarinic stimulation does not induce rhoA/ROCK-mediated Ca2+ sensitization of the contractile element in chicken gizzard smooth muscle.
Topics: Amides; Animals; Calcium; Carbachol; Chickens; Enzyme Inhibitors; Female; Gene Expression; Gizzard, Avian; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Verapamil | 2000 |
Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase.
Topics: Amides; Androstadienes; Animals; Arachidonic Acid; Calcium; Cell Membrane Permeability; Detergents; Enzyme Inhibitors; Femoral Artery; Glutathione Transferase; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Octoxynol; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Recombinant Fusion Proteins; rho-Associated Kinases; Type C Phospholipases; Wortmannin | 2001 |
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction | 2001 |
Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum.
Topics: Amides; Animals; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle Relaxants, Central; NG-Nitroarginine Methyl Ester; Penis; Phenylephrine; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Synaptic Transmission; Vasoconstrictor Agents | 2001 |
Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats.
Topics: Acetylcholine; Amides; Animals; Antigens; Biological Transport; Bronchi; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Enzyme Inhibitors; Muscle Contraction; Muscle, Smooth; Papaverine; Pyridines; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Time Factors; Vasodilator Agents | 2001 |
Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antineoplastic Agents; Aorta; Azepines; Calcium; Colchicine; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Male; Microtubules; Muscle Contraction; Muscle, Smooth, Vascular; Nocodazole; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents | 2001 |
Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Amides; Animals; Bethanechol; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Imidazoles; In Vitro Techniques; Indoles; Ion Channels; Isoquinolines; Muscle Contraction; Myosin Light Chains; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Time Factors; Urinary Bladder; Verapamil | 2001 |
Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats.
Topics: Acetylcholine; Amides; Animals; Bronchi; Calcium; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine Triphosphate; Immunoblotting; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Specific Pathogen-Free Organisms | 2001 |
Role of Rho-associated protein kinase in tone and calcium sensitivity of cannulated rat mesenteric small arteries.
Topics: Amides; Animals; Calcium; Drug Interactions; Intracellular Signaling Peptides and Proteins; Ionomycin; Ionophores; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxants, Central; Muscle Tonus; Muscle, Smooth, Vascular; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Vasoconstriction; Vasoconstrictor Agents | 2001 |
Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase.
Topics: Administration, Topical; Amides; Animals; Antihypertensive Agents; Carbachol; Ciliary Body; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Intraocular Pressure; Male; Muscle Contraction; Muscle, Smooth; Ophthalmic Solutions; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Tonometry, Ocular | 2001 |
Role of lysophosphatidylcholine in the desensitization of beta-adrenergic receptors by Ca(2+) sensitization in tracheal smooth muscle.
Topics: Adenylate Cyclase Toxin; Adrenergic beta-Agonists; Amides; Animals; Bucladesine; Calcium; Cholera Toxin; Colforsin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indoles; Isoproterenol; Lysophosphatidylcholines; Male; Maleimides; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Pyridines; Receptors, Adrenergic, beta; rho GTP-Binding Proteins; Spectrometry, Fluorescence; Theophylline; Trachea; Virulence Factors, Bordetella | 2001 |
Endothelin-1 stimulates human colonic myofibroblast contraction and migration.
Topics: Amides; Cell Division; Cell Movement; Cells, Cultured; Colon; Cytosol; Dose-Response Relationship, Drug; Endothelin-1; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosins; Phosphorylation; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Tumor Necrosis Factor-alpha | 2002 |
Regulation of capacitative and noncapacitative receptor-operated Ca2+ entry by rho-kinase in tracheal smooth muscle.
Topics: Actins; Amides; Animals; Calcium Channel Blockers; Calcium Signaling; Cytoskeleton; Enzyme Inhibitors; Guinea Pigs; Histamine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Sarcoplasmic Reticulum; Signal Transduction; Trachea | 2002 |
Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Amides; Animals; Bronchial Hyperreactivity; Enzyme Inhibitors; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Ketotifen; Lung; Lysophospholipids; Male; Muscle Contraction; Muscle, Smooth; Protein Serine-Threonine Kinases; Pyridines; Pyrilamine; rho-Associated Kinases; Structure-Activity Relationship | 2002 |
Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Arteries; Enzyme Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Potassium; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2002 |
Role of the short isoform of myosin light chain kinase in the contraction of cultured smooth muscle cells as examined by its down-regulation.
Topics: Amides; Animals; Azepines; Cell Line; DNA, Antisense; Down-Regulation; Enzyme Inhibitors; Guinea Pigs; Intracellular Signaling Peptides and Proteins; Isoenzymes; Isometric Contraction; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases | 2002 |