y 27632 has been researched along with Liver Cirrhosis in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, M; Fu, GB; Gao, Y; Huang, WJ; Wang, HY; Wu, HP; Xu, LY; Yan, HX; Zeng, M; Zhang, HD; Zhou, X | 1 |
| Bansal, MB; Chamroonkul, N | 1 |
| Beljaars, L; Casini, A; Frijlink, HW; Hinrichs, WLJ; Horvatovich, PL; Kim, YO; Klose, MHM; Meier-Menches, SM; Olinga, P; Poelstra, K; Post, E; Schuppan, D; Sijbrandi, NJ; Steendam, R; Teekamp, N; van Dijk, F; Zuidema, J | 1 |
| Chen, W; Huo, YM; Liu, DJ; Sun, YW; Wu, ZY | 1 |
| Beitinger, F; Bilzer, M; Gerbes, AL; Göke, B; Gülberg, V; Härtl, JM; Steib, CJ | 1 |
| Beljaars, L; Gosens, R; Lacombe, M; Poelstra, K; Post, E; Prakash, J; Reker-Smit, C; van Beuge, MM | 1 |
| Beljaars, L; Lacombe, M; Poelstra, K; Post, E; Prakash, J; Reker-Smit, C; van Beuge, MM | 1 |
| Hibi, T; Horikawa, H; Ishii, H; Kitamura, K; Kumagai, N; Kurita, S; Nakamoto, N; Saito, H; Tada, S; Toda, K; Tsunematsu, S | 1 |
| Enjoji, M; Iwamoto, H; Nakamuta, M; Nakashima, Y; Nawata, H; Sugimoto, R; Tada, S | 1 |
| Arii, S; Furumoto, K; Furuyama, H; Imamura, M; Isobe, N; Kaido, T; Mori, A; Murata, T; Nakamura, T; Nakao, T | 1 |
1 review(s) available for y 27632 and Liver Cirrhosis
| Article | Year |
|---|---|
Antifibrotics in liver disease: are we getting closer to clinical use?
Topics: Adaptive Immunity; Adipokines; Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Apoptosis; Cannabinoid Receptor Antagonists; Cell Communication; Cell Transdifferentiation; Cellular Senescence; Endothelin Receptor Antagonists; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; Extracellular Matrix; Galectins; Hepatic Stellate Cells; Humans; Immunity, Innate; Integrins; Liver Cirrhosis; NF-kappa B; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Receptors, Cannabinoid; Receptors, CCR; Renin-Angiotensin System; Signal Transduction; Toll-Like Receptors; Transforming Growth Factor beta | 2019 |
9 other study(ies) available for y 27632 and Liver Cirrhosis
| Article | Year |
|---|---|
The combined induction of liver progenitor cells and the suppression of stellate cells by small molecules reverts chronic hepatic dysfunction.
Topics: Amides; Animals; Carbon Tetrachloride; CD24 Antigen; Cells, Cultured; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Humans; Liver; Liver Cirrhosis; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Pyridines; Pyrimidines; Small Molecule Libraries; Stem Cells | 2021 |
The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor.
Topics: Amides; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Cell Line; Delayed-Action Preparations; Drug Carriers; Female; Humans; Liver Cirrhosis; Mice, Knockout; Microspheres; Protein Kinase Inhibitors; Pyridines; Receptor, Platelet-Derived Growth Factor beta; rho-Associated Kinases | 2019 |
Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension.
Topics: Amides; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Hydrogen Peroxide; Hypertension, Portal; Liver Cirrhosis; Male; Mesenteric Arteries; Norepinephrine; Oxidative Stress; Pyridines; Rats, Sprague-Dawley; Reactive Oxygen Species; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2014 |
Kupffer cell activation by hydrogen peroxide: a new mechanism of portal pressure increase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Gadolinium; Hydrogen Peroxide; Kupffer Cells; Liver Cirrhosis; Male; Microfilament Proteins; Portal Pressure; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfonamides; Xanthine; Xanthine Oxidase | 2010 |
Reduction of fibrogenesis by selective delivery of a Rho kinase inhibitor to hepatic stellate cells in mice.
Topics: Amides; Animals; Aorta; Drug Carriers; Hepatic Stellate Cells; Humans; Insulin-Like Growth Factor II; Liver; Liver Cirrhosis; Male; Mannosephosphates; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Serum Albumin | 2011 |
Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632.
Topics: Amides; Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; Drug Carriers; Enzyme Inhibitors; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Mannosephosphates; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Pyridines; Rats; Rats, Wistar; Receptor, IGF Type 2; rho-Associated Kinases; Serum Albumin; Tissue Distribution | 2011 |
Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis.
Topics: Alanine Transaminase; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aspartate Aminotransferases; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Choline Deficiency; Disease Models, Animal; DNA Damage; Fatty Liver; Liver; Liver Cirrhosis; Male; Organ Size; Oxidative Stress; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Tetrazoles; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Actins; Amides; Animals; Body Weight; Collagen; Dimethylnitrosamine; Enzyme Inhibitors; Hydroxyproline; Intracellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Male; Muscle, Smooth; Organ Size; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; RNA, Messenger | 2001 |
Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells.
Topics: Amides; Animals; Disease Progression; Enzyme Inhibitors; Homeodomain Proteins; Intracellular Signaling Peptides and Proteins; Liver; Liver Cirrhosis; Male; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; RNA, Messenger | 2001 |