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y 27632 and Invasiveness, Neoplasm

y 27632 has been researched along with Invasiveness, Neoplasm in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.13)18.2507
2000's11 (34.38)29.6817
2010's18 (56.25)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Baron, C; Besson, P; Bon, E; Brisson, L; Chadet, S; Lemoine, R; Lopez-Charcas, O; Moussata, D; Ouaissi, M; Poisson, L; Roger, S1
Idiris, A; Kumagai, H; Miyagi, Y; Miyazaki, K; Okamoto, R; Togo, S1
Cutiongco, MF; Gadegaard, N; Jagiełło, A; Kamphorst, JJ; Mackay, G; McGarry, L; Michalopoulou, E; Munro, J; Olson, MF; Pajic, M; Rath, N; Sumpton, D; Timpson, P; Unbekandt, M; Vennin, C1
Asghar, MY; Kemppainen, K; Lassila, T; Törnquist, K1
Bei, JX; Chen, L; Chen, MY; Feng, L; Li, X; Lian, YF; Qi, XK; Wang, Z; Xiang, T; Xiao, J; Yuan, J; Zeng, YX; Zhang, J; Zhang, Y1
Bratton, MR; Carriere, PP; Llopis, SD; Preyan, LC; Skripnikova, E; Tilghman, SL; Townley, I; Wang, G; Williams, CC; Zhang, Q; Zhong, Q; Zou, J1
Dwinell, MB; Hauser, AD; Roy, I; Williams, CL; Wilson, JM; Zimmerman, NP1
Chen, R; Cheng, Y; Geng, L; Li, Z; Zhang, Y1
Kurniawan, NA; Lim, CT; Sun, W1
Gu, SY; Li, Q; Li, XY; Liu, GL; Wang, YZ; Wu, X; Zhang, JG; Zhang, QD; Zhu, GH1
Belshaw, S; Bower, J; Crighton, D; Croft, DR; Drysdale, M; McArthur, D; McConnell, P; Mezna, M; Olson, MF; Pannifer, A; Schüttelkopf, AW; Sime, M; Unbekandt, M1
Jiang, L; Luo, W; Wen, J1
Liu, HB; Liu, J; Wang, ZM; Yang, DS; Ye, M; Zhang, YF1
Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A1
Bifulco, M; Laezza, C; Malfitano, AM; Pisanti, S1
Chang, HR; Chen, SL; Huang, HP; Hung, TW; Kao, YL; Lian, JD; Wang, CJ; Wu, SW1
Astuccio, M; Bryan, B; Callahan, W; Fellows, K; Gleason, D; Goodrow, C; Johnson, A; Lahey, D; Le, L; Monfredo, N; Ouellette, L; Partington, A; Routhier, A; Simone, P; Smith, A; Sullivan, K; Vezuli, B; West, E; Zhidro, S; Zohni, M1
Besson, A; Concha, C1
Boakes, A; Crighton, D; Heikkila, T; Kaye, SJ; Mezna, M; Olson, MF; Pang, L; Rushbrooke, M; Schroder, E; Turnbull, A; Wheatley, E1
Cho, KH; Han, JW; Jeong, KJ; Kang, J; Kim, YK; Lee, HY; Lee, J; Park, CG; Park, SY; Sohn, JS1
Chang, J; Dang, D; Lee, C; Ramos, DM; Siu, A1
Dou, KF; Li, KZ; Song, ZS; Wang, DS1
Bourguignon, LY; Diedrich, F; Gilad, E; Singleton, PA; Stern, R1
Fukushima, Y; Itoh, K; Miyahara, E; Nakagawa, H; Tamura, M; Yoshioka, K1
Beaudry, C; Berens, M; Kwan, A; Nakada, M; Rutka, JT; Rutten, F; Salhia, B1
Foran, E; Kenny, D; Lawler, K; Long, A; O'Sullivan, G1
Arihiro, K; Asahara, T; Fudaba, Y; Kobayashi, T; Miyata, Y; Ogawa, T; Okajima, M; Tashiro, H; Ushitora, Y1
Chen, XS; Han, LZ; Li, QG; Qiu, F; Xi, ZF; Xia, Q; Xue, F; Zhang, JJ; Zhang, M1
Akedo, H; Ishizaki, T; Itoh, K; Narumiya, S; Uehata, M; Yoshioka, K1
Bradshaw, D; Murphy, C; Myers, CE; Ramos, S; Somlyo, AP; Somlyo, AV1
Akedo, H; Ayaki, M; Imamura, F; Mukai, M1
Hirohashi, S; Sakamoto, M; Takamura, M1

Reviews

1 review(s) available for y 27632 and Invasiveness, Neoplasm

ArticleYear
[Recent progress in study of mechanism of invasion and metastasis of hepatocellular carcinoma].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 6

    Topics: Amides; Animals; Antigens, CD; Cadherins; Carcinoma, Hepatocellular; Enzyme Inhibitors; Humans; Integrin alpha6beta1; Integrins; Intracellular Signaling Peptides and Proteins; Kangai-1 Protein; Liver Neoplasms; Matrix Metalloproteinases; Membrane Glycoproteins; Monomeric GTP-Binding Proteins; Neoplasm Invasiveness; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pyridines; rho-Associated Kinases; Transcription Factors

2001

Other Studies

31 other study(ies) available for y 27632 and Invasiveness, Neoplasm

ArticleYear
Rock inhibition promotes Na
    Scientific reports, 2020, 08-07, Volume: 10, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Humans; NAV1.5 Voltage-Gated Sodium Channel; Neoplasm Invasiveness; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction

2020
Collective cancer cell invasion in contact with fibroblasts through integrin-α5β1/fibronectin interaction in collagen matrix.
    Cancer science, 2020, Volume: 111, Issue:12

    Topics: A549 Cells; Adenocarcinoma; Amides; Benzamides; Cancer-Associated Fibroblasts; Cell Adhesion; Cell Line, Tumor; Cell Movement; Chromones; Collagen; Colonic Neoplasms; Connective Tissue; Dioxoles; Epidermal Growth Factor; Fibroblasts; Fibronectins; Humans; Immunohistochemistry; Integrin alpha5beta1; MCF-7 Cells; Morpholines; Neoplasm Invasiveness; Pyridines; Spheroids, Cellular; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2020
Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.
    Cancer research, 2018, 06-15, Volume: 78, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Hydroxyphenethylamine; Amides; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Female; HEK293 Cells; Humans; Male; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyridines; rho-Associated Kinases; Signal Transduction

2018
Sphingosine 1-phosphate attenuates MMP2 and MMP9 in human anaplastic thyroid cancer C643 cells: Importance of S1P2.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Amides; Calpain; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pyridines; Receptors, Lysosphingolipid; rho-Associated Kinases; Sphingosine; Thyroid Carcinoma, Anaplastic

2018
SHROOM2 inhibits tumor metastasis through RhoA-ROCK pathway-dependent and -independent mechanisms in nasopharyngeal carcinoma.
    Cell death & disease, 2019, 01-25, Volume: 10, Issue:2

    Topics: Amides; Animals; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Female; Gene Knockdown Techniques; HEK293 Cells; Heterografts; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Transfection; Tumor Burden

2019
Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness.
    Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:9

    Topics: Actin Cytoskeleton; Amides; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Shape; Drug Resistance, Neoplasm; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Letrozole; Mesoderm; Neoplasm Invasiveness; Neoplasm Proteins; Nitriles; Protein Kinase Inhibitors; Proteomics; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Triazoles; Vimentin

2013
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
    Molecular carcinogenesis, 2015, Volume: 54, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Amides; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Humans; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Pyridines; Quinolones; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein; Vasodilator Agents

2015
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2014, Volume: 24, Issue:2

    Topics: Amides; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Humans; Neoplasm Invasiveness; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoC GTP-Binding Protein; Signal Transduction; Uterine Cervical Neoplasms

2014
Mechanistic adaptability of cancer cells strongly affects anti-migratory drug efficacy.
    Journal of the Royal Society, Interface, 2014, Oct-06, Volume: 11, Issue:99

    Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Cytochalasin D; Dipeptides; Extracellular Matrix; Female; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Microscopy, Confocal; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplastic Cells, Circulating; Nocodazole; Pyridines; Statistics, Nonparametric; Time-Lapse Imaging

2014
ROCK is involved in vasculogenic mimicry formation in hepatocellular carcinoma cell line.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Amides; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein

2014
A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
    Cell communication and signaling : CCS, 2014, Oct-05, Volume: 12

    Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Humans; Myotonin-Protein Kinase; Neoplasm Invasiveness; Protein Kinase Inhibitors; Pyrazoles; Pyridines; rho-Associated Kinases

2014
Rho‑associated kinase inhibitor, Y‑27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
    Molecular medicine reports, 2015, Volume: 12, Issue:5

    Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Myosin-Light-Chain Kinase; Neoplasm Invasiveness; Phosphorylation; Protein Processing, Post-Translational; Pyridines; rho-Associated Kinases; Signal Transduction; Urinary Bladder Neoplasms

2015
ROCK inhibitor Y-27632 inhibits the growth, migration, and invasion of Tca8113 and CAL-27 cells in tongue squamous cell carcinoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3

    Topics: Amides; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Neoplasm Invasiveness; Pyridines; rho-Associated Kinases; Time Factors; Tongue Neoplasms

2016
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
    Nature communications, 2016, Feb-08, Volume: 7

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles

2016
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway.
    Endocrine-related cancer, 2008, Volume: 15, Issue:4

    Topics: Actins; Amides; Arachidonic Acids; Blotting, Western; Breast Neoplasms; Cannabinoids; Cell Membrane; Cell Movement; Cytoskeleton; Cytosol; Female; Fluorescent Antibody Technique; Humans; Mevalonic Acid; Neoplasm Invasiveness; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2008
The suppressive effect of Rho kinase inhibitor, Y-27632, on oncogenic Ras/RhoA induced invasion/migration of human bladder cancer TSGH cells.
    Chemico-biological interactions, 2010, Jan-05, Volume: 183, Issue:1

    Topics: Aged; Aged, 80 and over; Amides; Cell Line, Tumor; Cell Movement; Cytoskeleton; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Invasiveness; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Transfection; Urinary Bladder Neoplasms

2010
Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth.
    Oncology reports, 2010, Volume: 23, Issue:3

    Topics: Amides; Animals; Cell Line, Tumor; Humans; Injections, Intraperitoneal; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases

2010
p27Kip1 is needed...for glioma invasion.
    Cell cycle (Georgetown, Tex.), 2010, Apr-15, Volume: 9, Issue:8

    Topics: Amides; Animals; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p27; Glioma; Neoplasm Invasiveness; Platelet-Derived Growth Factor; Protein Structure, Tertiary; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein

2010
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Catalytic Domain; Cell Line, Tumor; Collagen; Crystallography, X-Ray; Drug Combinations; Extracellular Matrix; Humans; Inhibitory Concentration 50; Laminin; Models, Molecular; Myotonin-Protein Kinase; Neoplasm Invasiveness; Protein Kinase Inhibitors; Protein Multimerization; Protein-Tyrosine Kinases; Proteoglycans; Pyridines; rho-Associated Kinases; Thiophenes

2011
The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion.
    Oncogene, 2012, Sep-27, Volume: 31, Issue:39

    Topics: Amides; Cell Line, Tumor; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lysophospholipids; Neoplasm Invasiveness; NF-kappa B; Nitriles; Ovarian Neoplasms; Peptide Hydrolases; Pyridines; rho-Associated Kinases; Sulfones; Urokinase-Type Plasminogen Activator

2012
Alphavbeta3 suppresses the RhoA-LIMK1 pathway in K1735 melanoma.
    Journal of the California Dental Association, 2012, Volume: 40, Issue:12

    Topics: Actin Depolymerizing Factors; Amides; Animals; Blotting, Western; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Humans; Immunoprecipitation; Integrin alphaVbeta3; Lim Kinases; Melanoma; Mice; Microscopy, Fluorescence; Neoplasm Invasiveness; Phosphoprotein Phosphatases; Phosphorylation; Pyridines; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Signal Transduction; Transfection

2012
Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
    World journal of gastroenterology, 2004, Jan-15, Volume: 10, Issue:2

    Topics: Amides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Lysophospholipids; Neoplasm Invasiveness; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction

2004
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: Amides; Amiloride; Animals; Breast Neoplasms; Cathepsin B; Caveolin 1; Caveolins; Cell Line, Tumor; Endosomes; Enzyme Inhibitors; Humans; Hyaluronan Receptors; Hyaluronic Acid; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Immunoglobulin G; Intracellular Signaling Peptides and Proteins; Lysosomes; Membrane Microdomains; Membrane Proteins; Neoplasm Invasiveness; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; RNA, Small Interfering; Sodium-Hydrogen Exchangers

2004
Intrathecal administration of Y-27632, a specific rho-associated kinase inhibitor, for rat neoplastic meningitis.
    Molecular cancer research : MCR, 2005, Volume: 3, Issue:8

    Topics: Actins; Agar; Amides; Animals; Brain; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cells, Cultured; Chemotaxis; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Floxuridine; GTP-Binding Proteins; Injections, Spinal; Mammary Neoplasms, Animal; Meningeal Neoplasms; Meningitis; Mice; Microscopy, Fluorescence; Myosin Light Chains; Neoplasm Invasiveness; Neoplasm Transplantation; Neurons; Osmosis; Phosphorylation; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; Signal Transduction; Time Factors

2005
Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1.
    Cancer research, 2005, Oct-01, Volume: 65, Issue:19

    Topics: Actins; Amides; Astrocytoma; Cell Line, Tumor; Cell Movement; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mutation; Neoplasm Invasiveness; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; rho-Associated Kinases; Transfection

2005
Mobility and invasiveness of metastatic esophageal cancer are potentiated by shear stress in a ROCK- and Ras-dependent manner.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:4

    Topics: Actins; Amides; Cell Adhesion; Cell Movement; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Esophageal Neoplasms; Fibronectins; Humans; Integrin alphaVbeta3; Intracellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Protein Serine-Threonine Kinases; Pyridines; ras Proteins; rho-Associated Kinases; Signal Transduction; Stress, Mechanical; Tissue Distribution; Tubulin

2006
Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, Volume: 7, Issue:2

    Topics: Amides; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Immunosuppressive Agents; Intracellular Signaling Peptides and Proteins; Liver Neoplasms, Experimental; Liver Transplantation; Male; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred BUF; rho-Associated Kinases; Signal Transduction; Tacrolimus

2007
Rho signaling inhibitor, Y-27632, inhibits invasiveness of metastastic hepatocellular carcinoma in a mouse model.
    Chinese medical journal, 2007, Dec-20, Volume: 120, Issue:24

    Topics: Actins; Amides; Animals; Apoptosis; Cytoskeleton; Enzyme Inhibitors; Female; Liver Neoplasms, Experimental; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pyridines; ras Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein

2007
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.
    Nature medicine, 1999, Volume: 5, Issue:2

    Topics: Amides; Animals; Cell Adhesion; Cell Transformation, Neoplastic; Enzyme Inhibitors; Intracellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; Transfection; Tumor Cells, Cultured

1999
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells.
    Biochemical and biophysical research communications, 2000, Mar-24, Volume: 269, Issue:3

    Topics: Amides; Animals; Azepines; Cattle; Cell Division; Cells, Cultured; Chemotaxis; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Transgenic; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Neoplasm Invasiveness; Neoplasm Metastasis; Neovascularization, Physiologic; Phosphoprotein Phosphatases; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:8

    Topics: Actins; Amides; Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cytoskeletal Proteins; Drug Interactions; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Lysophospholipids; Neoplasm Invasiveness; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; rho-Associated Kinases; Tumor Cells, Cultured; Tyrosine

2000