y 27632 has been researched along with Hypertension in 40 studies
*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 31 (77.50) | 29.6817 |
| 2010's | 7 (17.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Inui, J; Ishizaki, T; Kawahara, T; Maekawa, M; Morishita, T; Narumiya, S; Ono, T; Satoh, H; Tamakawa, H; Uehata, M; Yamagami, K | 1 |
| Beasley, JR; Belanger, L; Black, D; Chan, JH; Dunn, D; Ho, KK; Hu, B; Klon, A; Kultgen, SG; Ohlmeyer, M; Parlato, SM; Pham, Q; Ray, PC; Rong, Y; Roughton, AL; Walker, TL; Webb, M; Wright, J; Xu, K; Xu, Y; Zhang, L | 1 |
| Cho, S; Kim, HJ; Kim, SJ; Oh, SB | 1 |
| Costa, KD; Lee, JJ; Ma, B; Qiu, H; Stoll, S; Zhou, N | 1 |
| Hu, K; Liu, P; Tang, S; Zhang, HM; Zhou, XF | 1 |
| Ark, M; Aypar, E; Demirtaş, A; Gözübüyük, G; Ozdemir, A; Şahan, G; Turan, NN | 1 |
| Chen, HS; Jiang, FY; Li, RS; Li, WJ; Tu, Q; Wang, Y; Yin, RX | 1 |
| Hirooka, Y; Ito, K; Kimura, Y; Sagara, Y; Sunagawa, K | 2 |
| Chan, CK; Mak, JC; Man, RY; Vanhoutte, PM | 1 |
| Dorrance, AM; Leite, R; Linder, AE; Mills, TM; Webb, RC | 1 |
| Eto, M; Freitas, MR; Kirkbride, JA; Sassard, J; Schott, C; Stoclet, JC | 1 |
| Denniss, SG; Jeffery, AJ; Rush, JW | 1 |
| Guan, YY; Li, SY; Ma, MM; Wang, M | 1 |
| Chatterjee, P; Chiasson, VL; Kopriva, SE; Mitchell, BM; Nguyen, H; Young, KJ | 1 |
| Begaye, M; Carter, RW; Kanagy, NL | 1 |
| Hartshorne, DJ; Isaka, N; Ito, M; Kureishi, Y; Moriki, N; Nakano, T; Okamoto, R; Onishi, K; Seko, T | 1 |
| Kadokami, T; Koyanagi, M; Makino, N; Satoh, S; Sugano, M; Ueda, Y; Yoshikawa, Y | 1 |
| Asano, M; Nomura, Y | 1 |
| Hirooka, Y; Ito, K; Kaibuchi, K; Kishi, T; Sakai, K; Shimokawa, H; Takeshita, A | 1 |
| Hirooka, Y; Ito, K; Kaibuchi, K; Kimura, Y; Kishi, T; Shimokawa, H; Takeshita, A | 1 |
| Loberg, RD; Northcott, CA; Watts, SW; Wehrwein, EA | 1 |
| Bernie, J; Rajasekaran, M; Stein, P; White, S; Wilkes, N | 1 |
| Amano, M; Kaibuchi, K; Kawabata, S; Nakayama, M; Takefuji, M | 1 |
| Kobayashi, N; Matsuoka, H; Mita, S; Nakano, S; Yoshida, K | 1 |
| E Albo, M; Kuntz, S; Rajasekaran, M; Wilkes, N | 1 |
| Bae, YM; Cho, S; Choi, WH; Kim, B; Kim, J; Lee, CH; Lee, CK; Lee, YR | 1 |
| Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Márquez-Martín, A; Pérez-Guerrero, C | 1 |
| Jarajapu, YP; Knot, HJ | 1 |
| Ahn, DS; Cho, YE; Choi, SK; Kim, YH; Lee, YH; Morgan, KG; Ryu, SK | 1 |
| Hilgers, RH; Imig, JD; Jin, L; Webb, RC; Yin, J; Ying, Z; Zhao, X | 1 |
| Ahuja, P; Ehler, E; Pedrazzini, T; Perriard, E; Perriard, JC; Satoh, S | 1 |
| Ahn, DS; Cho, YE; Choi, SK; Kim, YH; Lee, YH; Morgan, KG; Shin, HM | 1 |
| Hilgers, RH; Todd, J; Webb, RC | 1 |
| Chrissobolis, S; Sobey, CG | 1 |
| Webb, RC; Weber, DS | 1 |
| Chitaley, K; Dorrance, AM; Mills, TM; Webb, RC | 1 |
| Fujishima, M; Ibayashi, S; Kitayama, J; Kitazono, T; Ooboshi, H; Takada, J | 1 |
| Honda, T; Kobayashi, N; Kobayashi, T; Matsuoka, H; Mita, S; Nakano, S; Tsubokou, Y | 1 |
| Ago, T; Fujishima, M; Ibayashi, S; Kamouchi, M; Kitazono, T; Ooboshi, H; Santa, N | 1 |
1 review(s) available for y 27632 and Hypertension
| Article | Year |
|---|---|
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Angina Pectoris; Animals; Arteriosclerosis; Calcium; Enzyme Inhibitors; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases | 2004 |
39 other study(ies) available for y 27632 and Hypertension
| Article | Year |
|---|---|
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.
Topics: Amides; Animals; Antihypertensive Agents; Calcium; Cell Adhesion; COS Cells; Enzyme Inhibitors; Guinea Pigs; Humans; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Recombinant Proteins; rho-Associated Kinases; Swine | 1997 |
Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.
Topics: Animals; Antihypertensive Agents; Binding Sites; Computer Simulation; Disease Models, Animal; Hypertension; Protein Kinase Inhibitors; Pyrimidines; Rats; rho-Associated Kinases; Structure-Activity Relationship; Triazines | 2009 |
T18/S19 diphosphorylation of myosin regulatory light chain impairs pulmonary artery relaxation in monocrotaline-induced pulmonary hypertensive rats.
Topics: Animals; Hypertension; Monocrotaline; Myosin Light Chains; Pulmonary Artery; Rats; rho-Associated Kinases | 2023 |
Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension.
Topics: Actins; Amides; Animals; Aorta, Thoracic; Blood Pressure; Cytoskeletal Proteins; Echocardiography; Hypertension; Male; Microscopy, Atomic Force; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Heavy Chains; Nipecotic Acids; Nuclear Proteins; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Serum Response Factor; Trans-Activators; Ultrasonography; Up-Regulation; Vascular Stiffness | 2017 |
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Topics: Amides; Animals; Apoptosis; Blood Pressure; Carotid Body; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Hypertension; Hypoxia; Male; NADPH Oxidases; Neuronal Plasticity; Onium Compounds; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; rho-Associated Kinases; Signal Transduction | 2019 |
Chronic ouabain treatment induces Rho kinase activation.
Topics: Amides; Animals; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Male; Myosin-Light-Chain Phosphatase; Ouabain; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases | 2015 |
TMEM16A contributes to angiotensin II-induced cerebral vasoconstriction via the RhoA/ROCK signaling pathway.
Topics: Amides; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anoctamin-1; Basilar Artery; Cells, Cultured; Chloride Channels; Disease Models, Animal; Evoked Potentials; Hypertension; Male; Muscle, Smooth, Vascular; Protein Phosphatase 1; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vasoconstriction | 2016 |
Activation of Rho-kinase in the brainstem enhances sympathetic drive in mice with heart failure.
Topics: Amides; Animals; Autonomic Pathways; Blood Vessels; Brain Stem; Cytoskeletal Proteins; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Norepinephrine; Organ Size; Pyridines; rho-Associated Kinases; Sympathetic Nervous System; Up-Regulation; Vasoconstriction | 2008 |
Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Antihypertensive Agents; Aorta, Thoracic; Blotting, Western; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isometric Contraction; Male; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Species Specificity; Vasoconstriction | 2009 |
Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production.
Topics: Amides; Animals; Antihypertensive Agents; Erectile Dysfunction; Ganglion Cysts; Hypertension; Indomethacin; Kidney; Male; Nitric Oxide; Nitroprusside; Penis; Phenylephrine; Pressure; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases | 2009 |
Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle.
Topics: Amides; Animals; Calcium; Calcium Chloride; Disease Models, Animal; Hypertension; Male; Mesenteric Arteries; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Pyridines; Rats; Receptors, Adrenergic, alpha-1; rho-Associated Kinases; Signal Transduction | 2009 |
RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction.
Topics: Amides; Animals; Carotid Artery, Common; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Hypertension; In Vitro Techniques; Muscle Contraction; Muscle Proteins; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Peroxides; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Thromboxane; rho-Associated Kinases; Signal Transduction | 2010 |
Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway.
Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cell Proliferation; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocytes, Smooth Muscle; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin | 2012 |
Interleukin-17 causes Rho-kinase-mediated endothelial dysfunction and hypertension.
Topics: Amides; Animals; Endothelial Cells; Hypertension; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pyridines; Rats; rho-Associated Kinases | 2013 |
Acute and chronic NOS inhibition enhances alpha(2)- adrenoreceptor-stimulated RhoA and Rho kinase in rat aorta.
Topics: Adrenergic alpha-Agonists; Amides; Animals; Aorta; Brimonidine Tartrate; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Penicillamine; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoconstriction | 2002 |
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Cells, Cultured; Cyclic GMP; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; NG-Nitroarginine Methyl Ester; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Threonine | 2003 |
Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure.
Topics: Amides; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Failure; Heterotrimeric GTP-Binding Proteins; Hypertension; Hypertrophy, Left Ventricular; Intracellular Signaling Peptides and Proteins; Myocardium; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Ultrasonography | 2003 |
Comparison of inhibitory effects of Y-27632, a Rho kinase inhibitor, in strips of small and large mesenteric arteries from spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: Amides; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Isometric Contraction; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Vasoconstrictor Agents; Vasodilation | 2003 |
Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.
Topics: Adenoviridae; Amides; Animals; Blood Pressure; Blotting, Western; Brain Stem; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genetic Vectors; Heart Rate; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Norepinephrine; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Solitary Nucleus; Sympathetic Nervous System; Transfection | 2003 |
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Topics: Amides; Animals; Blood Pressure; Enzyme Inhibitors; Hydralazine; Hypertension; Injections; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred WKY; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Solitary Nucleus | 2004 |
Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension.
Topics: Amides; Animals; Arteries; Calcium; Chromones; Desoxycorticosterone; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasoconstriction | 2004 |
Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Amides; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Electric Stimulation; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Penile Erection; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Serine-Threonine Kinases; Purinones; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Up-Regulation | 2004 |
Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats.
Topics: Amides; Animals; Collagen Type I; Collagen Type III; Coronary Vessels; Enzyme Inhibitors; Fibronectins; Hypertension; Intracellular Signaling Peptides and Proteins; Male; NADPH Oxidases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred Dahl; Receptors, LDL; Receptors, Oxidized LDL; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Scavenger Receptors, Class E; Signal Transduction; Transcription Factor RelA; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Rho-kinase inhibition suppresses bladder hyperactivity in spontaneously hypertensive rats.
Topics: Amides; Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Urinary Bladder; Urinary Incontinence; Urodynamics | 2005 |
Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hypertension; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasodilator Agents; Verapamil | 2005 |
Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin.
Topics: Amides; Animals; Aorta, Thoracic; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Indoles; Male; Mevalonic Acid; Muscle Relaxants, Central; Norepinephrine; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Inbred SHR; Simvastatin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amides; Animals; Benzophenanthridines; Blood Pressure; Calcium; Calcium Signaling; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Tonus; Muscle, Smooth, Vascular; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases | 2005 |
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Topics: Amides; Animals; Calcium; Flavonoids; Hypertension; Mesenteric Arteries; Mitogen-Activated Protein Kinases; Myosin Light Chains; Naphthalenes; Phosphorylation; Phosphorylcholine; Protein Kinase C; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Sphingosine; Vasoconstriction | 2006 |
Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats.
Topics: Amides; Angiotensin II; Animals; Aorta; Dose-Response Relationship, Drug; Enzyme Activation; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; NADPH Oxidases; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstriction | 2006 |
Ovariectomy augments hypertension through rho-kinase activation in the brain stem in female spontaneously hypertensive rats.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Brain Stem; Enzyme Activation; Estradiol; Female; Heart Rate; Hypertension; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Osmolar Concentration; Ovariectomy; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; rho-Associated Kinases; Telemetry | 2006 |
Re-expression of proteins involved in cytokinesis during cardiac hypertrophy.
Topics: Actomyosin; Amides; Angiotensin II; Animals; Antihypertensive Agents; Biomarkers; Calpain; Cardiomegaly; Cell Nucleus Division; Cullin Proteins; Cytokinesis; Heart; Hypertension; Intracellular Signaling Peptides and Proteins; Mice; Myocytes, Cardiac; Myofibrils; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred Dahl; rho GTP-Binding Proteins; rho-Associated Kinases; Up-Regulation | 2007 |
Enhanced stretch-induced myogenic tone in the basilar artery of spontaneously hypertensive rats.
Topics: Amides; Animals; Baroreflex; Basilar Artery; Calcium; Disease Models, Animal; Hypertension; Intracellular Signaling Peptides and Proteins; Mechanotransduction, Cellular; Pressoreceptors; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoconstriction | 2007 |
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats.
Topics: Amides; Angiotensin II; Animals; Base Sequence; Calcium; DNA Primers; Guanine Nucleotide Exchange Factors; Hypertension; Immunoprecipitation; Mesenteric Arteries; Myosin-Light-Chain Phosphatase; Protein Transport; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Signal Transduction | 2007 |
Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.
Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cerebral Arteries; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; Species Specificity; Vasodilator Agents; Vasomotor System | 2001 |
Enhanced relaxation to the rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats.
Topics: Amides; Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Mesenteric Arteries; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Serotonin; Vasodilation | 2001 |
Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Electric Stimulation; Ganglia; Genetic Predisposition to Disease; Hypertension; Male; Pelvis; Penile Erection; Penis; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Sodium Chloride; Stroke | 2001 |
Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats.
Topics: Acetylcholine; Amides; Animals; Basilar Artery; Body Weight; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Male; Muscle Relaxants, Central; Nitric Oxide Donors; Nitroprusside; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasodilation; Vasodilator Agents | 2002 |
Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats.
Topics: Amides; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; Hemodynamics; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Ribosomal Protein S6 Kinases; RNA, Messenger; Tetrazoles; Ventricular Remodeling | 2002 |
Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo.
Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Basilar Artery; Calcium Channel Blockers; Calcium Channels; Chronic Disease; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; NG-Nitroarginine Methyl Ester; Nicardipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Serotonin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |